Safety and effectiveness of endoluminal vacuum-assisted closure for esophageal defects: Systematic review and meta-analysis Article (Faculty180)
Overview
cited authors
- Aziz, Muhammad; Haghbin, Hossein; Sharma, Sachit; Weissman, Simcha; Saleem, Saad; Lee-Smith, Wade; Kobeissy, Abdallah; Nawras, Ali; Alastal, Yaseen
description
- Esophageal defects (leaks, fistulas, and perforations) are associated with significant morbidity and mortality. Endoluminal vacuum-assisted closure (EVAC) is a novel intervention that entails the use of sponges in the defect along with negative pressure to achieve granulation tissue formation and healing and has been gaining popularity. We performed a systematic review and pooled analysis of available literature to assess the safety and effectiveness of EVAC for esophageal defects. We queried PubMed/Medline, Embase, Cochrane, and Web of Science through September 25, 2020 to include all pertinent articles highlighting the safety and effectiveness profile of EVAC for esophageal defects. Pooled rates, 95 % confidence intervals (CIs), and heterogeneity ( ) were assessed for each outcome. A total of 18 studies with 423 patients were included (mean age 64.3 years and males 74.4 %). The technical success for EVAC was 97.1 % (CI: 95.4 %-98.7 %, = 0 %). The clinical success was 89.4 % (CI: 85.6 %-93.1 %, = 36.8 %). The overall all-cause mortality and adverse events (AEs) noted were 7.1 % (CI: 4.7 %-9.5 %, = 0 %) and 13.6 % (CI: 8.0 %-19.1 %, = 68.9 %), respectively. The pooled need for adjuvant therapy was 15.7 % (CI: 9.8 %-21.6 %, = 71.1 %). This systematic review and meta-analysis showed high rates of technical success, clinical success, and low all-cause mortality and AEs using EVAC. Although the technique is a promising alternative, the lack of comparative studies poses a challenge in making definite conclusions regarding use of EVAC compared to other endoscopic modalities, such as clips and stents.
authors
publication date
- 2021
published in
- Endoscopy international open Journal
Additional Document Info
start page
- E1371
end page
- E1380
volume
- 9