Roerhrs, Timothy; Claiborue, Deirdre; Knox, Michele; Roth, Thomas
description
Tested for dose and duration effects of residual sedation by administering ethanol (0.0, 0.5, and 0.9 g/kg) at 0830, 1030, and 0730 hrs, respectively to 10 healthy, normal-sleeping men. The Multiple Sleep Latency Test was conducted at 0930, 1130, 1330, 1530, 1730, 1930, and 2130 hrs, and a divided attention performance assessment was done at 1400, 1600, 1800, and 2000 hrs. Breath ethanol concentration for both doses was 0.04% at 1130 hrs, 0.01% at 1330 hrs, and 0 at 1530 hrs. A significant reduction in sleep latency was observed from 0930 to 1530 hrs, but not thereafter. Divided attention performance overall was significantly impaired on the 1400 hr test only. Data again showed residual sedation and suggest residual sedation is time limited and not affected in duration or intensity by dose. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
