Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats Article (Faculty180)

cited authors

  • Sari, Youssef; Sakai, Makiko; Weedman, Jason M; Rebec, George V; Bell, Richard L


  • Changes in glutamatergic transmission affect many aspects of neuroplasticity associated with ethanol and drug addiction. For instance, ethanol- and drug-seeking behavior is promoted by increased glutamate transmission in key regions of the motive circuit. We hypothesized that because glutamate transporter 1 (GLT1) is responsible for the removal of most extracellular glutamate, up-regulation or activation of GLT1 would attenuate ethanol consumption.


publication date

  • 2011

start page

  • 239

end page

  • 46


  • 46