Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats Article (Faculty180)

cited authors

  • Alhaddad, Hasan; Das, Sujan C; Sari, Youssef


  • Evidence suggests that glutamate transporter 1 (GLT-1) and cystine/glutamate exchanger transporter¬†(xCT) are critical in maintaining glutamate homeostasis. We have recently demonstrated that ceftriaxone treatment induced upregulation of GLT1 levels and attenuated ethanol intake; however, less is known about the involvement of xCT on ethanol intake. In this study, we investigated the effects of ceftriaxone on the levels of xCT in both continuous and relapse-like ethanol drinking, as well as GLT-1 isoforms, and glutamate aspartate transporter (GLAST) in relapse-like ethanol intake.


publication date

  • 2014

published in

start page

  • 4049

end page

  • 57


  • 231