Lee, Soo Ok; Chun, Jae Yeon; Nadiminty, Nagalakshmi; Lou, Wei; Feng, Siting; Gao, Allen C
description
Aberrant activation of androgen receptor (AR) plays an important role in the progression of castration resistant prostate cancer. Interleukin-4 (IL-4) enhances AR activation in the absence of androgen and stimulates castration resistant growth of androgen-sensitive prostate cancer cells. However, the mechanism of IL-4 mediated AR activation has not yet been revealed.
