Interleukin-4 activates androgen receptor through CBP/p300 Article (Faculty180)

cited authors

  • Lee, Soo Ok; Chun, Jae Yeon; Nadiminty, Nagalakshmi; Lou, Wei; Feng, Siting; Gao, Allen C


  • Aberrant activation of androgen receptor (AR) plays an important role in the progression of castration resistant prostate cancer. Interleukin-4 (IL-4) enhances AR activation in the absence of androgen and stimulates castration resistant growth of androgen-sensitive prostate cancer cells. However, the mechanism of IL-4 mediated AR activation has not yet been revealed.

publication date

  • 2009

published in

start page

  • 126

end page

  • 32


  • 69