NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation Article (Faculty180)

cited authors

  • Nadiminty, Nagalakshmi; Chun, Jae Yeon; Lou, Wei; Lin, Xin; Gao, Allen C


  • Androgen-deprivation therapy only causes a temporary regression of prostate cancer, as all tumors will eventually progress to refractory to hormonal therapy after 1-3 years of treatment. The underlying mechanisms of prostate cancer androgen refractory progression are incompletely understood. In this study, we employed in vitro as well as in vivo models to examine the role of NF-kappaB2/p52 in prostate cancer growth and androgen independent progression.

publication date

  • 2008

published in

start page

  • 1725

end page

  • 33


  • 68