Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives Article (Faculty180)

cited authors

  • Nadiminty, Nagalakshmi; Gao, Allen C


  • The emergence of castration resistance has remained the primary obstacle in prostate cancer therapy for several decades. Mechanisms likely to be involved in castration-resistant progression have been studied extensively, but have failed to yield many meaningful and effective targets. The re-activation of the androgen receptor (AR) in castration-resistant prostate cancer (CRPC) is now recognized as the central event in this process, and therapeutic modalities are being devised to combat it.

publication date

  • 2012

published in

start page

  • 287

end page

  • 95


  • 30