Sun, Meng; Liu, Chengfei; Nadiminty, Nagalakshmi; Lou, Wei; Zhu, Yezi; Yang, Joy; Evans, Christopher P; Zhou, Qinghua; Gao, Allen C
description
Signal transducer and activator of transcription 3 (Stat3) is an oncogenic transcriptional factor that plays a critical role in carcinogenesis and cancer progression and is a potential therapeutic target. Sanguinarine, a benzophenanthridine alkaloid derived primarily from the bloodroot plant, was identified previously as a novel inhibitor of survivin that selectively kills prostate cancer cells over "normal" prostate epithelial cells.
