Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives Article (Faculty180)

cited authors

  • Shaban, Eman; Bayliss, George; Malhotra, Deepa K; Shemin, Douglas; Wang, Li J; Gohh, Reginald; Dworkin, Lance D; Gong, Rujun

description

  • Organ transplantation is considered the ultimate therapy for end-stage organ disease. While pharmacologic immunosuppression is the mainstay of therapeutic strategies to prolong the survival of the graft, long-term use of immunosuppressive medications carries the risk of organ toxicity, malignancies, serious opportunistic infections, and diabetes. Therapies that promote recipient tolerance in solid organ transplantation are able to improve patient outcomes by eliminating the need for long-term immunosuppression.

authors

publication date

  • 2018

published in

start page

  • 205

end page

  • 213

volume

  • 4