Extracellular ubiquitin inhibits beta-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3beta and mitochondrial pathways Article (Faculty180)

cited authors

  • Singh, Mahipal; Roginskaya, Marina; Dalal, Suman; Menon, Bindu; Kaverina, Ekaterina; Boluyt, Marvin O; Singh, Krishna


  • Beta-adrenergic receptor (beta-AR) stimulation induces apoptosis in adult rat ventricular myocytes (ARVMs) via the activation of glycogen synthase kinase-3beta (GSK-3beta) and mitochondrial pathways. However, beta-AR stimulation induces apoptosis only in a fraction ( approximately 15-20%) of ARVMs. We hypothesized that ARVMs may secrete/release a survival factor(s) which protects 80-85% of cells from apoptosis.


publication date

  • 2010

published in

start page

  • 20

end page

  • 8


  • 86