It is a known fact that inflammation affects several physiological processes, including
the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways
have been associated with a number of neurodegenerative disorders and Alzheimer’s Disease
(AD) is one of them. However, much attention has been given to the link between tau and beta-
amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically
active lipid molecules could influence the pathophysiology of AD via a different mechanism of
inflammation. This review intends to highlight the role of inflammatory responses in the context of
AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-
LO).