Wang, Yongqing

Yongqing Wang
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Positions

Assistant Professor (research track), Medicine , College of Medicine and Life Sciences

Contact Info

Yongqing.Wang2@utoledo.edu

selected publications

Article (Faculty180)
- 2023
  
  Structure-Based Discovery of Selective Histone Deacetylase 8 Degraders with Potent Anticancer Activity. J Med Chem. 66:1186-1209.
- 2021
  
  Epigenetic down-regulation of microRNA-126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis. J Cell Mol Med.. 25:7078-7088.
- 2016
  
  Potential beneficial role for endothelin in scleroderma vasculopathy: inhibition of endothelial apoptosis by type B endothelin-receptor signaling. Journal of Scleroderma and Related Disorders. 1:213.
- 2015
  
  Cell-Free Circulating DNA in Systemic Sclerosis: Increased Levels and Global Cytosine Hypomethylation: Abstract Number: 3006. Arthritis & Rheumatology. 67:3618.
- 2015
  
  Cold Receptor Expression and Function in Human Dermal Fibroblast: Possible Role in the Pathogenesis of Scleroderma Fibrosis: Abstract Number: 3007. Arthritis & Rheumatology. 67:3619.
- 2015
  
  Epigenetics, the holy grail in the pathogenesis of systemic sclerosis. Rheumatology. 54:1759.
- 2015
  
  Isolation and Initial Characterization of Dermal Vascular Smooth Muscle Cells in Systemic Sclerosis: Abstract Number: 1928. Arthritis & Rheumatology. 67.
- 2014
  
  Endothelial dysfunction in systemic sclerosis. Current opinion in rheumatology. 26:615.
- 2013
  
  CC-220: A Clinical Stage Immunomodulatory, Antifibrotic Drug For Systemic Sclerosis.: 820. Arthritis & Rheumatism. 65.
- 2013
  
  Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation.: 668. Arthritis & Rheumatism. 65.
- 2013
  
  Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. Journal of cellular and molecular medicine. 17:1291.
- 2012
  
  CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy.: 1494. Arthritis & Rheumatism. 64.
- 2012
  
  Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype.: 2297. Arthritis & Rheumatism. 64.
- 2012
  
  Platelet Release Products Mediate Endothelial Apoptosis: A Possible Role for Thrombospondin 1-CD36 Pathway in SSc-Endothelial Apoptosis.: 2296. Arthritis & Rheumatism. 64.
- 2012
  
  SS. 1.1 Decrease activity of DNA demethylase in SSC fibroblast and microvascular endothelial cells: a possible mechanism for persistent SSC phenotype. Rheumatology. 51:ii5.
- 2011
  
  Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. Blood. 117:6172.
- 2006
  
  Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 54:2271.
- 2003
  
  Antiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland: evidence for the involvement of transforming growth factor $beta$1 in calcitonin action. Endocrinology. 144:2164.
- 2002
  
  NF-$kappa$B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nature cell biology. 4:888.
- 2001
  
  Calcitonin is a prostate epithelium-derived growth stimulatory peptide. Molecular and Cellular Endocrinology. 181:69.
Article (Web of Science)
- 2021
  
  Epigenetic down-regulation of microRNA-126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.
  Full Text via DOI: 10.1111/jcmm.16727 PMID: 34137496
- 2015
  
  Epigenetics, the holy grail in the pathogenesis of systemic sclerosis. RHEUMATOLOGY. 54:1759-1770.
  Full Text via DOI: 10.1093/rheumatology/keu155
- 2013
  
  Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 17:1291-1299.
  Full Text via DOI: 10.1111/jcmm.12105
- 2011
  
  Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality. BLOOD. 117:6172-6183.
  Full Text via DOI: 10.1182/blood-2010-12-325647
Meeting Abstract (Web of Science)
- 2017
  
  Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells Enhances the Transition of Endothelial to Mesenchymal Cells (Endo-MT) Induced By TGF beta through DownRegulating PI3/Akt Signaling Pathway By Targeting PIK3R2. ARTHRITIS & RHEUMATOLOGY.
- 2017
  
  Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells: Identification of Epigenetically Affected Key Genes and Pathways. ARTHRITIS & RHEUMATOLOGY.
- 2016
  
  Down-Regulation of microRNA-126 in Scleroderma Microvascular Endothelial Cells (MVECs) Is Associated with Impaired Responses to Vascular Endothelial Growth Factor (VEGF) and Defective Angiogenesis. ARTHRITIS & RHEUMATOLOGY.
- 2016
  
  The Role of Endothelin 1 in Activation of Vascular Smooth Muscle Cells in Systemic Sclerosis; Increased Cell Proliferation and Resistance to Apoptosis Mediated By Endotehlin B Receptors. ARTHRITIS & RHEUMATOLOGY.
- 2015
  
  Cell-Free Circulating DNA in Systemic Sclerosis: Increased Levels and Global Cytosine Hypomethylation. ARTHRITIS & RHEUMATOLOGY.
- 2015
  
  Cold Receptor Expression and Function in Human Dermal Fibroblast: Possible Role in the Pathogenesis of Scleroderma Fibrosis. ARTHRITIS & RHEUMATOLOGY.
- 2015
  
  Isolation and Initial Characterization of Dermal Vascular Smooth Muscle Cells in Systemic Sclerosis. ARTHRITIS & RHEUMATOLOGY.
- 2014
  
  THE PRESENCE OF A COLD TEMPERATURE SENSOR IN THE VASCULAR ENDOTHELIUM: ENHANCED EXPRESSION IN SSC SKIN AND ENDOTHELIAL CELLS DYSFUNCTION AFTER ACTIVATION. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. S13-S13.
- 2013
  
  CC-220: A Clinical Stage Immunomodulatory, Antifibrotic Drug For Systemic Sclerosis. ARTHRITIS AND RHEUMATISM. S349-S349.
- 2013
  
  Enhanced Expression Of The Cold-Sensing Receptor-TRPM8 In Scleroderma Endothelial Cells and Skin and Endothelial Dysfunction Following TRPM8 Activation.. ARTHRITIS AND RHEUMATISM. S286-S286.
- 2012
  
  CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy. ARTHRITIS AND RHEUMATISM. S641-S641.
- 2012
  
  Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype.. ARTHRITIS AND RHEUMATISM. S970-S971.
- 2012
  
  Platelet Release Products Mediate Endothelial Apoptosis: A Possible Role for Thrombospondin 1-CD36 Pathway in SSc-Endothelial Apoptosis.. ARTHRITIS AND RHEUMATISM. S970-S970.
- 2012
  
  PLATELET-MEDIATED ENDOTHELIAL APOPTOSIS IN SSc: A POSSIBLE ROLE FOR THROMBOSPONDIN 1-CD36 PATHWAY. RHEUMATOLOGY. 38-38.
- 2010
  
  Effect of selective and dual endothelin receptor antagonists (ERAs) on SSc and normal endothelial cells apoptosis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. S80-S81.
- 2010
  
  DECREASE EXPRESSION OF BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN SSC TISSUES AND IN ENDOTHELIAL CELLS LEADING TO ENHANCED SUSCEPTIBILITY TO APOPTOSIS. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. S73-S73.
- 2008
  
  Arginine vasopressin in scleroderma: Tissue expression, enhanced production by monocytes and modulation of collagen, endotheline-1, endothelial nitric oxide and prostacyclin Synthases expression levels. ARTHRITIS AND RHEUMATISM. S833-S833.
- 2008
  
  Epigenetic repression of the bone morphogenetic protein type II receptor expression in scleroderma endothelial cells: A possible basis for enhanced SSc endothelial vulnerability to apoptosis. ARTHRITIS AND RHEUMATISM. S928-S928.
- 2005
  
  The role epigenetics and Fli-1 gene repression in the maintenance of the activated fibroblast phenotype in fibrotic scleroderma skin and lung.. ARTHRITIS AND RHEUMATISM. S463-S463.
Proceedings (Faculty180)
Review Article (Web of Science)
- 2014
  
  Endothelial dysfunction in systemic sclerosis. CURRENT OPINION IN RHEUMATOLOGY. 615-620.
  Full Text via DOI: 10.1097/BOR.0000000000000112
- 2014
  
  Endothelial dysfunction in systemic sclerosis. CURRENT OPINION IN RHEUMATOLOGY. 615-620.
  Full Text via DOI: 10.1097/bor.0000000000000112

full name

Yongqing Wang

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Cumulative publications in Scholars@UToledo

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