Yakov Lapitsky
- Professor, Associate Chair, and Undergraduate Director, Chemical Engineering , College of Engineering
Overview
overview
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Yakov Lapitsky is a professor in the Department of Chemical Engineering at the University of Toledo (UT). He received his B.S. and B.Ch.E. degrees in chemistry and chemical engineering at the University of Minnesota in 2001 and his Ph.D. in chemical engineering at the University of Delaware in 2006. Prior to joining the faculty at UT in 2009, he completed a postdoctoral fellowship in the biomaterials field at the University of Toronto. His research focuses on colloid and polymer science and controlled release technologies, with much of the work centered on the fundamentals and applications of polyelectrolyte-based soft materials. His work in these areas has been recognized with several awards, including the NSF CAREER Award, Outstanding Faculty Researcher and Outstanding Undergraduate Mentor awards from UT’s College of Engineering, and the Eleni and Evangelos Theodosiou/Sigma Xi Young Investigator Award from the UT Chapter of the Sigma Xi Scientific Research Society.
Publications
selected publications
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Article (Faculty180)
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2024Smart exosomes enhance PDAC targeted therapy. Journal of Controlled Release. 368:413-429.
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2022Preparation of polyelectrolyte complex nanoparticles with tunable and narrow size distributions by template polymerization. Colloid and Polymer Science. 300:707-719.
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2021Poly(allylamine)/tripolyphosphate coacervates for encapsulation and long-term release of cetylpyridinium chloride. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 629:127490.
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2020Biomolecular uptake effects on chitosan/tripolyphosphate micro- and nanoparticle stability. Colloids and Surfaces B: Biointerfaces. 193:111081.
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2020Highly sustained release of bactericides from complex coacervates. ACS Applied Bio Materials. 3:8427-8437.
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2020PEGylation and folate conjugation effects on the stability of chitosan-tripolyphosphate nanoparticles. International Journal of Biological Macromolecules. 158:1055-1062.
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2019Pitfalls in analyzing release from chitosan/tripolyphosphate micro- and nanoparticlesgels. European Journal of Pharmaceutics and Biopharmaceutics. 142:204-215.
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2018Customizing polyelectrolyte complex shapes through photolithographic directed assembly. Soft Matter. 14:521-532.
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2018Effect of small molecules on the phase behavior and coacervation of aqueous solutions of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrene sulfonate). Journal of Colloid and Interface Science. 518:216-224.
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2018Photolithographically assembled polyelectrolyte complexes as shape-directing templates for thermoreversible gels. Journal of Materials Chemistry B.
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2017Analysis of chitosan/tripolyphosphate micro- and nanogel yields is key to understanding their protein uptake performance. Journal of Colloid and Interface Science. 494:242.
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2017On the kinetics of chitosan/tripolyphosphate micro- and nanogel aggregation and their effects on particle polydispersity. Journal of Colloid and Interface Science. 486:27.
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2017Preparation of chitosan/tripolyphosphate nanoparticles with highly tunable size and low polydispersity. Colloids and Surfaces B: Biointerfaces. 157:110-117.
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2016Ionically cross-linked polymer networks for the multiple-month release of small molecules. ACS Applied Materials & Interfaces. 8:4323.
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2016Preparation and timed release properties of self-rupturing gels. ACS Applied Materials & Interfaces. 8:29015.
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2015Factors affecting the stability of chitosan/tripolyphosphate micro- and nanogels: Resolving the opposing findings. Journal of Materials Chemistry B. 3:5957.
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2015Photodirected assembly of polyelectrolyte complexes. Polymer. 60:69.
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2014Formation and dissolution of chitosan/pyrophosphate nanoparticles: Is the ionic crosslinking of chitosan reversible?. Colloids and Surfaces B: Biointerfaces. 115:100.
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2014Ionically crosslinked polyelectrolyte nanocarriers: Recent advances and open problems. Current Opinion in Colloid & Interface Science. 19:122.
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2014
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2014
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2013Determining the colloidal behavior of ionically cross-linked polyelectrolytes with isothermal titration calorimetry. The Journal of Physical Chemistry B. 117:9548.
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2013Physicochemical and antibacterial properties of surfactant mixtures with quaternized chitosan microgels. Carbohydrate Polymers. 93:709.
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2012Salt-assisted mechanistic analysis of chitosan/tripolyphosphate micro-and nanogel formation. Biomacromolecules. 13:3868.
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2011
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2011Stabilization of bioderived surfactant/polyelectrolyte complexes through surfactant conjugation to the biopolymer. Colloid and Polymer Science. 289:1589.
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2011Stimulus-responsive polyelectrolyte particles: From nanospheres to macroscopic beads. Journal of Dispersion Science and Technology. 32:1119.
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2011Transport of epidermal growth factor in the stroke-injured brain. Journal of Controlled Release. 149:225.
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2010Hydrogel/electrospun fiber composites influence neural stem/progenitor cell fate. Soft Matter. 6:2227.
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2010Interactions of anionic surfactants with cationic polyelectrolyte gels: Competitive binding and application in separation processes. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 372:196.
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2009Accelerated release of a sparingly soluble drug from an injectable hyaluronan--methylcellulose hydrogel. Journal of Controlled Release. 140:218.
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2009An injectable drug delivery platform for sustained combination therapy. Journal of Controlled Release. 138:205.
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2008Modular biodegradable biomaterials from surfactant and polyelectrolyte mixtures. Biomacromolecules. 9:166.
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2007Calorimetric determination of surfactant/polyelectrolyte binding isotherms. The Journal of Physical Chemistry B. 111:8379.
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2006Formation and structural control of surfactant and polyelectrolyte gels. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 282:118.
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2006
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2006Surfactant and polyelectrolyte gel particles that swell reversibly. Langmuir. 22:6375.
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2004Formation of surfactant and polyelectrolyte gel particles in aqueous solutions. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 250:179.
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Article (Web of Science)
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2021Poly(allylamine)/tripolyphosphate coacervates for encapsulation and long-term release of cetylpyridinium chloride. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS. 629.Full Text via DOI: 10.1016/j.colsurfa.2021.127490
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2020Highly Sustained Release of Bactericides from Complex Coacervates. ACS APPLIED BIO MATERIALS. 3:8427-8437.Full Text via DOI: 10.1021/acsabm.0c00763
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2020Biomolecular uptake effects on chitosan/tripolyphosphate micro- and nanoparticle stability. COLLOIDS AND SURFACES B-BIOINTERFACES. 193.Full Text via DOI: 10.1016/j.colsurfb.2020.111081 PMID: 32403037
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2020PEGylation and folate conjugation effects on the stability of chitosan-tripolyphosphate nanoparticles. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 158:1055-+.Full Text via DOI: 10.1016/j.ijbiomac.2020.04.118 PMID: 32330499
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2019Pitfalls in analyzing release from chitosan/tripolyphosphate micro- and nanoparticles. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 142:204-215.Full Text via DOI: 10.1016/j.ejpb.2019.06.020 PMID: 31226368
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2019Supramolecular Strategy Effects on Chitosan Bead Stability in Acidic Media: A Comparative Study. GELS. 5.Full Text via DOI: 10.3390/gels5010011 PMID: 30823549
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2018Photolithographically assembled polyelectrolyte complexes as shape-directing templates for thermoreversible gels. JOURNAL OF MATERIALS CHEMISTRY B. 6:7594-7604.Full Text via DOI: 10.1039/c8tb02104j
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2018Effect of small molecules on the phase behavior and coacervation of aqueous solutions of poly(diallyldimethylammonium chloride) and poly (sodium 4-styrene sulfonate). JOURNAL OF COLLOID AND INTERFACE SCIENCE. 518:216-224.Full Text via DOI: 10.1016/j.jcis.2018.02.029
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2018Customizing polyelectrolyte complex shapes through photolithographic directed assembly. SOFT MATTER. 14:521-532.Full Text via DOI: 10.1039/c7sm02022h
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2018Poly(allylamine)/tripolyphosphate coacervates enable high loading and multiple-month release of weakly amphiphilic anionic drugs: an in vitro study with ibuprofen. RSC ADVANCES. 8:19409-19419.Full Text via DOI: 10.1039/c8ra02588f
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2017Preparation of chitosan/tripolyphosphate nanoparticles with highly tunable size and low polydispersity. COLLOIDS AND SURFACES B-BIOINTERFACES. 157:110-117.Full Text via DOI: 10.1016/j.colsurfb.2017.05.055
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2017Analysis of chitosan/tripolyphosphate micro- and nanogel yields is key to understanding their protein uptake performance. JOURNAL OF COLLOID AND INTERFACE SCIENCE. 494:242-254.Full Text via DOI: 10.1016/j.jcis.2017.01.066
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2017On the kinetics of chitosan/tripolyphosphate micro- and nanogel aggregation and their effects on particle polydispersity. JOURNAL OF COLLOID AND INTERFACE SCIENCE. 486:27-37.Full Text via DOI: 10.1016/j.jcis.2016.09.050
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2016Preparation and Timed Release Properties of Self-Rupturing Gels. ACS APPLIED MATERIALS & INTERFACES. 8:29015-29024.Full Text via DOI: 10.1021/acsami.6b09370
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2016Ionically Cross-Linked Polymer Networks for the Multiple-Month Release of Small Molecules. ACS APPLIED MATERIALS & INTERFACES. 8:4323-4335.Full Text via DOI: 10.1021/acsami.5b10070
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2015Photodirected assembly of polyelectrolyte complexes. POLYMER. 60:69-76.Full Text via DOI: 10.1016/j.polymer.2015.01.027
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2015Ionically Cross-Linked Poly(allylamine) as a Stimulus-Responsive Underwater Adhesive: Ionic Strength and pH Effects. LANGMUIR. 31:1564-1574.Full Text via DOI: 10.1021/la504611x
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2015Factors affecting the stability of chitosan/tripolyphosphate micro- and nanogels: resolving the opposing findings. JOURNAL OF MATERIALS CHEMISTRY B. 3:5957-5970.Full Text via DOI: 10.1039/c5tb00431d
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2014Simple Preparation of Polyelectrolyte Complex Beads for the Long-Term Release of Small Molecules. LANGMUIR. 30:8915-8922.Full Text via DOI: 10.1021/la501771k
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2014Self-Assembly of Stiff, Adhesive and Self-Healing Gels from Common Polyelectrolytes. LANGMUIR. 30:7771-7777.Full Text via DOI: 10.1021/la404606y
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2014Formation and dissolution of chitosan/pyrophosphate nanoparticles: Is the ionic crosslinking of chitosan reversible?. COLLOIDS AND SURFACES B-BIOINTERFACES. 115:100-108.Full Text via DOI: 10.1016/j.colsurfb.2013.11.032
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2013Determining the Colloidal Behavior of Ionically Cross-Linked Polyelectrolytes with Isothermal Titration Calorimetry. JOURNAL OF PHYSICAL CHEMISTRY B. 117:9548-9557.Full Text via DOI: 10.1021/jp405384b
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2013Physicochemical and antibacterial properties of surfactant mixtures with quaternized chitosan microgels. CARBOHYDRATE POLYMERS. 93:709-717.Full Text via DOI: 10.1016/j.carbpol.2012.12.054
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2012Salt-Assisted Mechanistic Analysis of Chitosan/Tripolyphosphate Micro- and Nanogel Formation. BIOMACROMOLECULES. 13:3868-3876.Full Text via DOI: 10.1021/bm3014236
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2011Monovalent Salt Enhances Colloidal Stability during the Formation of Chitosan/Tripolyphosphate Microgels. LANGMUIR. 27:10392-10399.Full Text via DOI: 10.1021/la201194a
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2011Stabilization of bioderived surfactant/polyelectrolyte complexes through surfactant conjugation to the biopolymer. COLLOID AND POLYMER SCIENCE. 289:1589-1596.Full Text via DOI: 10.1007/s00396-011-2484-y
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2011Stimulus-Responsive Polyelectrolyte Particles: From Nanospheres to Macroscopic Beads. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY. 32:1119-1128.Full Text via DOI: 10.1080/01932691.2010.497704
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2011Transport of epidermal growth factor in the stroke-injured brain. Journal of Controlled Release. 149:225-235.Full Text via DOI: 10.1016/j.jconrel.2010.10.022
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2010Interactions of anionic surfactants with cationic polyelectrolyte gels: Competitive binding and application in separation processes. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS. 372:196-203.Full Text via DOI: 10.1016/j.colsurfa.2010.10.021
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2010Hydrogel/electrospun fiber composites influence neural stem/progenitor cell fate. SOFT MATTER. 6:2227.Full Text via DOI: 10.1039/b924349f
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2009Accelerated release of a sparingly soluble drug from an injectable hyaluronan–methylcellulose hydrogel. Journal of Controlled Release. 140:218-223.Full Text via DOI: 10.1016/j.jconrel.2009.05.025
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2009An injectable drug delivery platform for sustained combination therapy. Journal of Controlled Release. 138:205-213.Full Text via DOI: 10.1016/j.jconrel.2009.05.009
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2009Tunable immunonanoparticle binding to cancer cells: thermodynamic analysis of targeted drug delivery vehicles. SOFT MATTER. 5:1074.Full Text via DOI: 10.1039/b814204a
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2008Modular Biodegradable Biomaterials from Surfactant and Polyelectrolyte Mixtures. BIOMACROMOLECULES. 9:166-174.Full Text via DOI: 10.1021/bm7009416
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2007Calorimetric Determination of Surfactant/Polyelectrolyte Binding Isotherms. JOURNAL OF PHYSICAL CHEMISTRY B. 111:8379-8387.Full Text via DOI: 10.1021/jp0678958
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2006Formation and structural control of surfactant and polyelectrolyte gels. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS. 282-283:118-128.Full Text via DOI: 10.1016/j.colsurfa.2006.01.017
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2006Surfactant and Polyelectrolyte Gel Particles that Swell Reversibly. LANGMUIR. 22:6375-6379.Full Text via DOI: 10.1021/la0604329
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2006Surfactant and polyelectrolyte gel particles for encapsulation and release of aromatic oils. SOFT MATTER. 2:779.Full Text via DOI: 10.1039/b607910e
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Conference Poster (Faculty180)
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Lecture or Panel Discussion (Faculty180)
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2020Colloidal and interfacial phenomena in polyelectrolyte self-assembly. Department of Chemical and Biomolecular Engineering, Ohio University, Athens, Ohio.
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2020Formation, properties and limitations of chitosan/tripolyphosphate micro- and nanogels. Department of Chemical and Biomolecular Engineering, Ohio University, Athens, Ohio.
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2018Polyelectrolyte-based soft materials for wet adhesion, controlled release and beyond. Department of Chemical and Biomolecular Engineering, Case Western Reserve University.
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2017Polyelectrolyte-based soft materials for wet adhesion, controlled release and beyond. Chemical and Biomedical Engineering Department, Cleveland State University.
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2016Analysis and applications of polyelectrolyte-based soft materials. SafeWhite Inc..
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2016Analysis and applications of polyelectrolyte-based soft materials. Department of Chemical and Environmental Engineering (Sigma Xi Award Lecture), University of Toledo.
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2016Calorimetric analysis and applications of polyelectrolyte/multivalent counterion complexes. Lubrizol Advanced Materials.
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2012Formation and drug carrier properties of ionically crosslinked polyelectrolyte microgels. Department of Bioengineering, University of Toledo.
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2009Polyelectrolyte-based soft materials: Self-assembly, gelation and application. Department of Chemical and Materials Engineering, University of Alberta.
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2009Polyelectrolyte-based soft materials: Self-assembly, gelation and application. Department of Chemical and Biomolecular Engineering, University of Akron.
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2009Towards mechanistic design of polyelectrolyte-based soft materials. Department of Chemical and Biomolecular Engineering, Clarkson University.
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2009Towards mechanistic design of polyelectrolyte-based soft materials. Chemical Engineering Department, Colorado School of Mines.
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2008Surfactant and polyelectrolyte complexes: Self-assembly, gelation and application. Department of Chemical Engineering & Applied Chemistry, University of Toronto.
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2008Surfactant and polyelectrolyte complexes: Self-assembly, gelation and application. Department of Chemical Engineering, McGill University.
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2008Surfactant-biopolyelectrolyte complexes: Self-assembly, gelation and application. Department of Chemical and Environmental Engineering, University of Toledo.
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2007Surfactant and polyelectrolyte complexes: Self-assembly, gelation and application. Department of Chemical and Biochemical Engineering, Rutgers University.
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Meeting Abstract (Web of Science)
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2018Photopatterned polyelectrolyte complexes as shape-directing templates for thermoreversible biopolymer gels. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2018Understanding protein uptake properties of ionically crosslinked micro- and nanogels. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2017Microgel and coacervate formation in polyelectrolyte/multivalent ion mixtures. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2013Formation and properties of chitosan/pyrophosphate micro- and nanoparticles. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2013Formation of super-stiff adhesive gels through the ionic crosslinking of polyelectrolytes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2013Kinetic and mechanistic analysis of chitosan/tripolyphosphate microgel formation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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2013Photodirected assembly of polyelectrolyte complexes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
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Patent (Faculty180)
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Presentation (Faculty180)
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Review Article (Web of Science)
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2014Ionically crosslinked polyelectrolyte nanocarriers: Recent advances and open problems. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. 122-130.Full Text via DOI: 10.1016/j.cocis.2014.03.014
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Contact
full name
- Yakov Lapitsky