Taylor, William R

William R Taylor
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Positions

Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

william.taylor3@utoledo.edu

selected publications

Article (Faculty180)
- 2023
  
  Regulation of Ferroptosis by Transcription Factor E2F1 and RB. Research square.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation. Experimental cell research. 413:113063.
- 2022
  
  Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division. The Journal of biological chemistry. 102263.
- 2022
  
  Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis. Journal of medicinal chemistry.
- 2021
  
  Identification and initial characterization of a potent inhibitor of ferroptosis. Journal of cellular biochemistry. 122:413-424.
- 2019
  
  Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific reports. 9:5926.
- 2018
  
  A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. Journal of natural products. 81:1693-1700.
- 2018
  
  Analysis of the role of GSK3 in the mitotic checkpoint. Scientific reports. 8:14259.
- 2018
  
  Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. Organic & biomolecular chemistry. 16:1465-1479.
- 2016
  
  Conduction electron spin resonance of small silver particles.. International Journal of Pharmacology. 14:1.
- 2016
  
  Multiple Levels of Regulation of Sororin by Cdk1 and Aurora B. Journal of cellular biochemistry. 117:351.
- 2016
  
  Mutations in BOREALIN cause thyroid dysgenesis. Human molecular genetics. 26:599.
- 2016
  
  OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLoS One. 11:e0153518.
- 2016
  
  The comparison of glycosphingolipids isolated from an epithelial ovarian cancer cell line and a nontumorigenic epithelial ovarian cell line using MALDI-MS and MALDI-MS/MS. Carbohydrate research. 431:6.
- 2016
  
  Traveling through Mitosis with the Chromosomal Passenger Complex
- 2015
  
  Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores. Nature communications. 6:6775.
- 2013
  
  Monopolar Spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) and assembly of the Mitotic Checkpoint Complex. Journal of Biological Chemistry. jbc.
- 2013
  
  Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex. The Journal of biological chemistry. 288:35149-58.
- 2012
  
  Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation. The Journal of Biochemistry. 151:361.
- 2011
  
  Regulation of sororin by Cdk1-mediated phosphorylation. J Cell Sci. 124:2976.
- 2011
  
  Regulation of sororin by Cdk1-mediated phosphorylation. Journal of cell science. 124:2976-87.
- 2010
  
  Regulation of Borealin by phosphorylation at serine 219. Journal of cellular biochemistry. 111:1291.
- 2009
  
  Investigating the role of Aurora kinases in RAS signaling. Journal of cellular biochemistry. 106:33.
- 2009
  
  Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. Molecular cancer therapeutics. 1535.
- 2009
  
  Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. Molecular cancer therapeutics. 8:1646-54.
- 2009
  
  Short and long-term tumor cell responses to Aurora kinase inhibitors. Experimental cell research. 315:1085.
- 2008
  
  Gonadotoxicity evaluation of oral artemisinin derivatives in male rats.. International Journal of Pharmacology. 7:412.
- 2007
  
  Analysis of mitotic phosphorylation of borealin. BMC cell biology. 8:5.
- 2007
  
  Analysis of mitotic phosphorylation of borealin. BMC cell biology. 8:5.
- 2007
  
  Borealin is repressed in response to p53/Rb signaling. Cell biology international. 31:1470.
- 2006
  
  Control of the G 2/M transition. Molecular biotechnology. 32:227.
- 2005
  
  p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2. Journal of cell science. 118:1821.
- 2004
  
  FACS-based detection of phosphorylated histone H3 for the quantitation of mitotic cells. Methods in molecular biology (Clifton, N.J.). 281:293-9.
- 2003
  
  G2 arrest in response to topoisomerase II inhibitors: the role of p53. Cancer research. 63:4074.
- 2001
  
  Regulation of p53 expression by the RAS-MAP kinase pathway. Oncogene. 20:2527.
- 2001
  
  Regulation of the G2/M transition by p53. Oncogene. 20:1803.
- 2001
  
  p130/E2F4 binds to and represses the cdc2 promoter in response to p53. Journal of Biological Chemistry. 276:1998.
- 1999
  
  Control of Diamondback Moth by Application of Neem Extracts.. Pakistan Journal of Biological Sciences. 8:887.
- 1999
  
  Induction of target cell apoptosis by channel catfish cytotoxic cells. Cellular immunology. 195:110.
- 1999
  
  Mechanisms of G2 arrest in response to overexpression of p53. Molecular biology of the cell. 10:3607.
- 1999
  
  p53 inhibits entry into mitosis when DNA synthesis is blocked. Oncogene. 18:283.
- 1998
  
  A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides. Proceedings of the National Academy of Sciences. 95:14775.
- 1998
  
  The p53 network. Journal of Biological Chemistry. 273:1.
- 1997
  
  Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase. Oncogene. 15:1035.
- 1997
  
  Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability. Cancer research. 57:4876.
- 1995
  
  MULTIPLE EFFECTS ON DRUG-SENSITIVITY, GENOME STABILITY AND MALIGNANT POTENTIAL BY COMBINATIONS OF H-RAS, C-MYC AND MUTANT P53 GENE OVEREXPRESSION. International journal of oncology. 7:57.
- 1995
  
  The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited. Trends in biochemical sciences. 20:431.
- 1995
  
  p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proceedings of the National Academy of Sciences. 92:8493.
- 1994
  
  A role for myn in Ha-ras transformation of mouse 10T1/2 fibroblasts. Molecular carcinogenesis. 10:8.
- 1994
  
  Antisense oligodeoxyribonucleotide inhibition of TGF-$\beta$ 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells. Gene. 149:25.
- 1994
  
  Comparison of glyceraldehyde-3-phosphate dehydrogenase and 28S-ribosomal RNA gene expression as RNA loading controls for northern blot analysis of cell lines of varying malignant potential. Analytical biochemistry. 216:223.
- 1994
  
  Computational studies on Ribavirin binding to RNA-dependent RNA polymerase, inducing Crimean-Congo hemorrhagic fever.. Science International. 1:119.
- 1994
  
  Regulation of the metastatic phenotype by growth factors and oncogenes
- 1993
  
  Cell motility, invasion, and malignancy induced by overexpression of K-FGF or bFGF. Experimental cell research. 204:295.
- 1992
  
  Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination.. Oncogene. 7:1383.
Article (Web of Science)
- 2021
  
  A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. BIOORGANIC CHEMISTRY. 116.
  Full Text via DOI: 10.1016/j.bioorg.2021.105297 PMID: 34509798
- 2020
  
  Identification and initial characterization of a potent inhibitor of ferroptosis. JOURNAL OF CELLULAR BIOCHEMISTRY.
  Full Text via DOI: 10.1002/jcb.29870 PMID: 33377232
- 2019
  
  Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-42251-5 PMID: 30976078
- 2018
  
  Analysis of the role of GSK3 in the mitotic checkpoint. SCIENTIFIC REPORTS. 8.
  Full Text via DOI: 10.1038/s41598-018-32435-w
- 2018
  
  A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. JOURNAL OF NATURAL PRODUCTS. 81:1693-1700.
  Full Text via DOI: 10.1021/acs.jnatprod.7b00892
- 2018
  
  Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:1465-1479.
  Full Text via DOI: 10.1039/c7ob03086j
- 2017
  
  Bioactivities of n-hexane fraction of Vateria copallifera and GC-MS analysis of its phytoconstituents. INDUSTRIAL CROPS AND PRODUCTS. 97:87-92.
  Full Text via DOI: 10.1016/j.indcrop.2016.12.011
- 2017
  
  Mutations in BOREALIN cause thyroid dysgenesis. HUMAN MOLECULAR GENETICS. 26:599-610.
  Full Text via DOI: 10.1093/hmg/ddw419
- 2016
  
  The comparison of glycosphingolipids isolated from an epithelial ovarian cancer cell line and a nontumorigenic epithelial ovarian cell line using MALDI-MS and MALDI-MS/MS. CARBOHYDRATE RESEARCH. 431:6-14.
  Full Text via DOI: 10.1016/j.carres.2016.05.006
- 2016
  
  OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLOS ONE. 11.
  Full Text via DOI: 10.1371/journal.pone.0153518
- 2016
  
  Multiple Levels of Regulation of Sororin by Cdk1 and Aurora B. JOURNAL OF CELLULAR BIOCHEMISTRY. 117:351-360.
  Full Text via DOI: 10.1002/jcb.25277
- 2015
  
  Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores. NATURE COMMUNICATIONS. 6.
  Full Text via DOI: 10.1038/ncomms7775
- 2013
  
  Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:35149-35158.
  Full Text via DOI: 10.1074/jbc.M113.522375
- 2013
  
  Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:35149-35158.
  Full Text via DOI: 10.1074/jbc.m113.522375
- 2012
  
  Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation. JOURNAL OF BIOCHEMISTRY. 151:361-369.
  Full Text via DOI: 10.1093/jb/mvs015
- 2011
  
  Regulation of sororin by Cdk1-mediated phosphorylation. JOURNAL OF CELL SCIENCE. 124:2976-2987.
  Full Text via DOI: 10.1242/jcs.085431
- 2010
  
  Regulation of Borealin by Phosphorylation at Serine 219. JOURNAL OF CELLULAR BIOCHEMISTRY. 111:1291-1298.
  Full Text via DOI: 10.1002/jcb.22853
- 2009
  
  Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. MOLECULAR CANCER THERAPEUTICS. 8:1646-1654.
  Full Text via DOI: 10.1158/1535-7163.MCT-08-1084
- 2009
  
  Short and long-term tumor cell responses to Aurora kinase inhibitors. EXPERIMENTAL CELL RESEARCH. 315:1085-1099.
  Full Text via DOI: 10.1016/j.yexcr.2009.02.008
- 2009
  
  Investigating the role of Aurora Kinases in RAS signaling. JOURNAL OF CELLULAR BIOCHEMISTRY. 106:33-41.
  Full Text via DOI: 10.1002/jcb.21974
- 2009
  
  Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. MOLECULAR CANCER THERAPEUTICS. 8:1646-1654.
  Full Text via DOI: 10.1158/1535-7163.mct-08-1084
- 2007
  
  Borealin is repressed in response to p53/Rb signaling. Cell Biology International. 31:1470-1481.
  Full Text via DOI: 10.1016/j.cellbi.2007.06.013
Chapter (Faculty180)
- 2009
  
  Targeting the cell cycle to kill cancer cells. Pharmacology. Elsevier. 429.
- 2005
  
  Whole-body vibration perception thresholds of recumbent subjects: part 1âsupine posture. Human Response to Vibration. McGraw-Hill New York. 1.
- 2004
  
  Analyzing the G2/M checkpoint. Checkpoint Controls and Cancer. Springer. 51.
- 2004
  
  FACS-based detection of phosphorylated histone H3 for the quantitation of mitotic cells. Checkpoint Controls and Cancer. Springer. 293.
- 1997
  
  p53-Dependent Signaling in Response to DNA Damage or Arrest of DNA Synthesis and its Role in Cell Cycle Control. Genomic Instability and Immortality in Cancer. Springer. 69.
Meeting Abstract (Web of Science)
- 2018
  
  Abstract 4293: Glycogen synthase kinase 3 b maintains mitotic arrest by regulating mitotic checkpoint complex levels
  Full Text via DOI: 10.1158/1538-7445.am2018-4293
- 2017
  
  Glycogen Synthase Kinase 3 maintains mitotic arrest by regulating mitotic checkpoint complex levels.. MOLECULAR BIOLOGY OF THE CELL.
- 2016
  
  BOREALIN Mutations in Thyroid Dysgenesis Reveal a New Function of this Protein in Cell Adhesion and Migration. HORMONE RESEARCH IN PAEDIATRICS. 15-16.
- 2014
  
  Ferroptotic small molecules for the treatment of Ras-mutated cancers. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2013
  
  Maintenance of a stable pool of CPC at the centromere requires the C-terminus of Borealin and Haspin kinase. MOLECULAR BIOLOGY OF THE CELL.
- 2011
  
  Analysis of sororin phosphorylation and dephosphorylation.. MOLECULAR BIOLOGY OF THE CELL.
- 2011
  
  MPS1 kinase activity is essential for C-MAD2 production and assembly of the mitotic checkpoint complex (MCC).. MOLECULAR BIOLOGY OF THE CELL.
- 2009
  
  Length of mitotic arrest induced by microtubule stabilizing drugs determines cell death after mitotic slippage. CANCER RESEARCH.
- 2009
  
  Short and long term tumor cell responses to Aurora kinase inhibitors. CANCER RESEARCH.
Other Scholarly Work (Faculty180)
Proceedings (Faculty180)

full name

William R Taylor

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