Taylor, William R

William R Taylor
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Positions

Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

william.taylor3@utoledo.edu

selected publications

Article (Faculty180)
- 2024
  
  CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes. Journal of medicinal chemistry. 67:16107-16127.
- 2023
  
  Regulation of Ferroptosis by Transcription Factor E2F1 and RB. Research square.
- 2022
  
  Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones. European Journal of Medicinal Chemistry. 56:1652-1663.
- 2022
  
  C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation. Experimental cell research. 413:113063.
- 2022
  
  Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis. Journal of medicinal chemistry.
- 2021
  
  Identification and initial characterization of a potent inhibitor of ferroptosis. Journal of cellular biochemistry. 122:413-424.
- 2019
  
  Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific reports. 9:5926.
- 2018
  
  Analysis of the role of GSK3 in the mitotic checkpoint. Scientific reports. 8:14259.
- 2016
  
  Multiple Levels of Regulation of Sororin by Cdk1 and Aurora B. Journal of cellular biochemistry. 117:351.
- 2016
  
  Mutations in BOREALIN cause thyroid dysgenesis. Human molecular genetics. 26:599.
- 2016
  
  OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLoS One. 11:e0153518.
- 2016
  
  Traveling through Mitosis with the Chromosomal Passenger Complex
- 2012
  
  Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation. The Journal of Biochemistry. 151:361.
- 2011
  
  Regulation of sororin by Cdk1-mediated phosphorylation. J Cell Sci. 124:2976.
- 2007
  
  Analysis of mitotic phosphorylation of borealin. BMC cell biology. 8:5.
- 2007
  
  Borealin is repressed in response to p53/Rb signaling. Cell biology international. 31:1470.
- 2003
  
  G2 arrest in response to topoisomerase II inhibitors: the role of p53. Cancer research. 63:4074.
- 2001
  
  Regulation of p53 expression by the RAS-MAP kinase pathway. Oncogene. 20:2527.
- 2001
  
  Regulation of the G2/M transition by p53. Oncogene. 20:1803.
- 2001
  
  p130/E2F4 binds to and represses the cdc2 promoter in response to p53. Journal of Biological Chemistry. 276:1998.
- 1998
  
  A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides. Proceedings of the National Academy of Sciences. 95:14775.
- 1997
  
  Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase. Oncogene. 15:1035.
- 1997
  
  Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability. Cancer research. 57:4876.
- 1995
  
  MULTIPLE EFFECTS ON DRUG-SENSITIVITY, GENOME STABILITY AND MALIGNANT POTENTIAL BY COMBINATIONS OF H-RAS, C-MYC AND MUTANT P53 GENE OVEREXPRESSION. International journal of oncology. 7:57.
- 1995
  
  The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited. Trends in biochemical sciences. 20:431.
- 1994
  
  A role for myn in Ha-ras transformation of mouse 10T1/2 fibroblasts. Molecular carcinogenesis. 10:8.
- 1994
  
  Antisense oligodeoxyribonucleotide inhibition of TGF-$\beta$ 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells. Gene. 149:25.
- 1994
  
  Comparison of glyceraldehyde-3-phosphate dehydrogenase and 28S-ribosomal RNA gene expression as RNA loading controls for northern blot analysis of cell lines of varying malignant potential. Analytical biochemistry. 216:223.
- 1994
  
  Regulation of the metastatic phenotype by growth factors and oncogenes
- 1992
  
  Evidence for synergistic interactions between ras, myc and a mutant form of p53 in cellular transformation and tumor dissemination.. Oncogene. 7:1383.
Article (Web of Science)
- 2021
  
  A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics. BIOORGANIC CHEMISTRY. 116.
  Full Text via DOI: 10.1016/j.bioorg.2021.105297 PMID: 34509798
- 2020
  
  Identification and initial characterization of a potent inhibitor of ferroptosis. JOURNAL OF CELLULAR BIOCHEMISTRY.
  Full Text via DOI: 10.1002/jcb.29870 PMID: 33377232
- 2019
  
  Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-42251-5 PMID: 30976078
- 2018
  
  Analysis of the role of GSK3 in the mitotic checkpoint. SCIENTIFIC REPORTS. 8.
  Full Text via DOI: 10.1038/s41598-018-32435-w
- 2018
  
  A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera. JOURNAL OF NATURAL PRODUCTS. 81:1693-1700.
  Full Text via DOI: 10.1021/acs.jnatprod.7b00892
- 2018
  
  Small-molecule anticancer agents kill cancer cells by harnessing reactive oxygen species in an iron-dependent manner. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:1465-1479.
  Full Text via DOI: 10.1039/c7ob03086j
- 2017
  
  Bioactivities of n-hexane fraction of Vateria copallifera and GC-MS analysis of its phytoconstituents. INDUSTRIAL CROPS AND PRODUCTS. 97:87-92.
  Full Text via DOI: 10.1016/j.indcrop.2016.12.011
- 2017
  
  Mutations in BOREALIN cause thyroid dysgenesis. HUMAN MOLECULAR GENETICS. 26:599-610.
  Full Text via DOI: 10.1093/hmg/ddw419
- 2016
  
  The comparison of glycosphingolipids isolated from an epithelial ovarian cancer cell line and a nontumorigenic epithelial ovarian cell line using MALDI-MS and MALDI-MS/MS. CARBOHYDRATE RESEARCH. 431:6-14.
  Full Text via DOI: 10.1016/j.carres.2016.05.006
- 2016
  
  OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLOS ONE. 11.
  Full Text via DOI: 10.1371/journal.pone.0153518
- 2016
  
  Multiple Levels of Regulation of Sororin by Cdk1 and Aurora B. JOURNAL OF CELLULAR BIOCHEMISTRY. 117:351-360.
  Full Text via DOI: 10.1002/jcb.25277
- 2015
  
  Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores. NATURE COMMUNICATIONS. 6.
  Full Text via DOI: 10.1038/ncomms7775
- 2013
  
  Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:35149-35158.
  Full Text via DOI: 10.1074/jbc.M113.522375
- 2013
  
  Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:35149-35158.
  Full Text via DOI: 10.1074/jbc.m113.522375
- 2012
  
  Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation. JOURNAL OF BIOCHEMISTRY. 151:361-369.
  Full Text via DOI: 10.1093/jb/mvs015
- 2011
  
  Regulation of sororin by Cdk1-mediated phosphorylation. JOURNAL OF CELL SCIENCE. 124:2976-2987.
  Full Text via DOI: 10.1242/jcs.085431
- 2010
  
  Regulation of Borealin by Phosphorylation at Serine 219. JOURNAL OF CELLULAR BIOCHEMISTRY. 111:1291-1298.
  Full Text via DOI: 10.1002/jcb.22853
- 2009
  
  Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. MOLECULAR CANCER THERAPEUTICS. 8:1646-1654.
  Full Text via DOI: 10.1158/1535-7163.MCT-08-1084
- 2009
  
  Short and long-term tumor cell responses to Aurora kinase inhibitors. EXPERIMENTAL CELL RESEARCH. 315:1085-1099.
  Full Text via DOI: 10.1016/j.yexcr.2009.02.008
- 2009
  
  Investigating the role of Aurora Kinases in RAS signaling. JOURNAL OF CELLULAR BIOCHEMISTRY. 106:33-41.
  Full Text via DOI: 10.1002/jcb.21974
- 2009
  
  Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. MOLECULAR CANCER THERAPEUTICS. 8:1646-1654.
  Full Text via DOI: 10.1158/1535-7163.mct-08-1084
- 2007
  
  Borealin is repressed in response to p53/Rb signaling. Cell Biology International. 31:1470-1481.
  Full Text via DOI: 10.1016/j.cellbi.2007.06.013
Chapter (Faculty180)
- 2009
  
  Targeting the cell cycle to kill cancer cells. Pharmacology. Elsevier. 429.
- 2004
  
  Analyzing the G2/M checkpoint. Checkpoint Controls and Cancer. Springer. 51.
- 2004
  
  FACS-based detection of phosphorylated histone H3 for the quantitation of mitotic cells. Checkpoint Controls and Cancer. Springer. 293.
Meeting Abstract (Web of Science)
- 2018
  
  Abstract 4293: Glycogen synthase kinase 3 b maintains mitotic arrest by regulating mitotic checkpoint complex levels
  Full Text via DOI: 10.1158/1538-7445.am2018-4293
- 2017
  
  Glycogen Synthase Kinase 3 maintains mitotic arrest by regulating mitotic checkpoint complex levels.. MOLECULAR BIOLOGY OF THE CELL.
- 2016
  
  BOREALIN Mutations in Thyroid Dysgenesis Reveal a New Function of this Protein in Cell Adhesion and Migration. HORMONE RESEARCH IN PAEDIATRICS. 15-16.
- 2014
  
  Ferroptotic small molecules for the treatment of Ras-mutated cancers. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2013
  
  Maintenance of a stable pool of CPC at the centromere requires the C-terminus of Borealin and Haspin kinase. MOLECULAR BIOLOGY OF THE CELL.
- 2011
  
  Analysis of sororin phosphorylation and dephosphorylation.. MOLECULAR BIOLOGY OF THE CELL.
- 2011
  
  MPS1 kinase activity is essential for C-MAD2 production and assembly of the mitotic checkpoint complex (MCC).. MOLECULAR BIOLOGY OF THE CELL.
- 2009
  
  Length of mitotic arrest induced by microtubule stabilizing drugs determines cell death after mitotic slippage. CANCER RESEARCH.
- 2009
  
  Short and long term tumor cell responses to Aurora kinase inhibitors. CANCER RESEARCH.
Other Scholarly Work (Faculty180)
- 2004
  
  PTGF$\beta$ protects p53-null cells from PALA-mediated death
Proceedings (Faculty180)

full name

William R Taylor

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