Messer, William S

William S Messer
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Positions

Professor of Pharmacology
Professor of Medicinal Chemistry, Pharmacology , College of Pharmacy and Pharmaceutical Sciences

Contact Info

William.Messer@utoledo.edu

selected publications

Article (Web of Science)
- 2022
  
  Effects of the Partial M-1 Muscarinic Cholinergic Receptor Agonist CDD-0102A on Stereotyped Motor Behaviors and Reversal Learning in the BTBR Mouse Model of Autism. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 25:64-74.
  Full Text via DOI: 10.1093/ijnp/pyab079 PMID: 34791301
- 2017
  
  Linking muscarinic receptor activation to UPS-mediated object memory destabilization: Implications for long-term memory modification and storage. NEUROBIOLOGY OF LEARNING AND MEMORY. 145:151-164.
  Full Text via DOI: 10.1016/j.nlm.2017.10.007
- 2014
  
  Evaluation of 1,2,5-thiadiazoles as modulators of M-1/M-5 muscarinic receptor subtypes. BIOORGANIC & MEDICINAL CHEMISTRY. 22:1838-1844.
  Full Text via DOI: 10.1016/j.bmc.2014.01.049
- 2012
  
  The Selective M-1 Muscarinic Cholinergic Agonist CDD-0102A Enhances Working Memory and Cognitive Flexibility. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 340:588-594.
  Full Text via DOI: 10.1124/jpet.111.187625
- 2011
  
  Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. NEUROPHARMACOLOGY. 61:12-24.
  Full Text via DOI: 10.1016/j.neuropharm.2011.02.010
- 2011
  
  Theoretical studies of the solvent effect on conformational equilibria and atomic charges for isolated and hydrogen-bonded dimethoxy thiadiazoles. COMPUTATIONAL AND THEORETICAL CHEMISTRY. 966:194-206.
  Full Text via DOI: 10.1016/j.comptc.2011.02.034
- 2011
  
  Theoretical Studies of the In-Solution Isomeric Protonation of Non-Aromatic Six-Member Rings with Two Nitrogens. JOURNAL OF PHYSICAL CHEMISTRY B. 115:4758-4767.
  Full Text via DOI: 10.1021/jp202241m
- 2010
  
  Theoretical and Experimental Studies of the Isomeric Protonation in Solution for a Prototype Aliphatic Ring Containing Two Nitrogens. JOURNAL OF PHYSICAL CHEMISTRY B. 114:349-360.
  Full Text via DOI: 10.1021/jp9082085
- 2007
  
  On again, off again effects of gonadectomy on the acoustic startle reflex in adult male rats. PHYSIOLOGY & BEHAVIOR. 90:473-482.
  Full Text via DOI: 10.1016/j.physbeh.2006.10.010
- 2006
  
  Design and Synthesis of Novel Derivatives of the Muscarinic Agonist Tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-Methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] Ether (CDD-0304): Effects of Structural Modifications on the Binding and Activity at Muscarinic Receptor Subtypes and Chimeras. JOURNAL OF MEDICINAL CHEMISTRY. 49:7518-7531.
  Full Text via DOI: 10.1021/jm0606995
- 2005
  
  Classification of the mode of inhibition of high-affinity choline uptake using capillary electrophoresis with electrochemical detection at an enzyme-modified microelectrode. ANALYTICAL BIOCHEMISTRY. 339:216-222.
  Full Text via DOI: 10.1016/j.ab.2005.01.047
- 2005
  
  Antimuscarinic Drugs for Overactive Bladder and Their Potential Effects on Cognitive Function in Older Patients. Journal of the American Geriatrics Society. 53:2195-2201.
  Full Text via DOI: 10.1111/j.1532-5415.2005.00537.x
- 2005
  
  Theoretical Studies of the Tautomeric Equilibria for Five-Member N-Heterocycles in the Gas Phase and in Solution. JOURNAL OF PHYSICAL CHEMISTRY B. 109:22588-22602.
  Full Text via DOI: 10.1021/jp053076w
- 2004
  
  Conformational Analysis and Derivation of Molecular Mechanics Parameters for Esters and Thioesters. JOURNAL OF PHYSICAL CHEMISTRY A. 108:10173-10185.
  Full Text via DOI: 10.1021/jp0490251
- 2004
  
  Muscarinic acetylcholine receptors in the brain of the zebrafish (Danio rerio) measured by radioligand binding techniques. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 137:349-353.
  Full Text via DOI: 10.1016/j.cca.2004.03.002
- 2003
  
  Synthesis and Biological Characterization of 1-Methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole Derivatives as Muscarinic Agonists for the Treatment of Neurological Disorders. JOURNAL OF MEDICINAL CHEMISTRY. 46:4273-4286.
  Full Text via DOI: 10.1021/jm0301235
- 2002
  
  A simple spatial alternation task for assessing memory function in zebrafish. Behavioural Processes. 58:125-132.
  Full Text via DOI: 10.1016/s0376-6357(02)00025-6
- 2002
  
  Development of CDD-0102 as a selective M1 agonist for the treatment of Alzheimer's disease. DRUG DEVELOPMENT RESEARCH. 57:200-213.
  Full Text via DOI: 10.1002/ddr.10153
- 2002
  
  Evaluation of the inhibition of choline uptake in synaptosomes by capillary electrophoresis with electrochemical detection. ELECTROPHORESIS. 23:3699-3704.
  Full Text via DOI: 10.1002/1522-2683(200211)23:21<3699::aid-elps3699>3.0.co;2-e
- 2002
  
  Functional characterization of alternatively spliced 5-HT2 receptor isoforms from the pharynx and muscle of the parasitic nematode, Ascaris suum. JOURNAL OF NEUROCHEMISTRY. 83:249-258.
  Full Text via DOI: 10.1046/j.1471-4159.2002.01067.x
- 2002
  
  Internal standard method for the measurement of choline and acetylcholine by capillary electrophoresis with electrochemical detection. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 775:49-56.
  Full Text via DOI: 10.1016/s1570-0232(02)00269-6
- 2002
  
  The utility of muscarinic agonists in the treatment of alzheimer’s disease. JOURNAL OF MOLECULAR NEUROSCIENCE. 19:187-193.
  Full Text via DOI: 10.1007/s12031-002-0031-5
- 2001
  
  Design, Synthesis, and Biological Characterization of Bivalent 1-Methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole Derivatives as Selective Muscarinic Agonists. JOURNAL OF MEDICINAL CHEMISTRY. 44:4563-4576.
  Full Text via DOI: 10.1021/jm0102405
- 1999
  
  Alternative-splicing of serotonin receptor isoforms in the pharynx and muscle of the parasitic nematode, Ascaris suum. MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 101:95-106.
  Full Text via DOI: 10.1016/s0166-6851(99)00059-6
- 1999
  
  First fatty acylated dipeptides to affect muscarinic receptor ligand binding. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 9:3363-3368.
  Full Text via DOI: 10.1016/s0960-894x(99)00604-6
- 1999
  
  Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M₁muscarinic receptors. British Journal of Pharmacology. 126:735-745.
  Full Text via DOI: 10.1038/sj.bjp.0702301
- 1997
  
  Synthesis and Biological Characterization of 1,4,5,6-Tetrahydropyrimidine and 2-Amino-3,4,5,6-tetrahydropyridine Derivatives as Selective m1 Agonists. JOURNAL OF MEDICINAL CHEMISTRY. 40:1230-1246.
  Full Text via DOI: 10.1021/jm960467d
- 1996
  
  Heart and T-Lymphocyte Cell Surfaces Both Exhibit Positive Cooperativity in Binding a Membrane-Lytic Toxin. JOURNAL OF MEMBRANE BIOLOGY. 150:113-122.
  Full Text via DOI: 10.1007/s002329900035
- 1996
  
  Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists. BIOORGANIC & MEDICINAL CHEMISTRY. 4:1605-1615.
  Full Text via DOI: 10.1016/0968-0896(96)00152-6
- 1995
  
  1,2,5-Thiadiazole derivatives of arecoline stimulate M1 receptors coupled to phosphoinositide turnover. BRAIN RESEARCH. 693:118-123.
  Full Text via DOI: 10.1016/0006-8993(95)00724-5
- 1995
  
  Evidence for muscarinic acetyicholine receptor subtypes in the pigeon telencephalon. JOURNAL OF COMPARATIVE NEUROLOGY. 362:271-282.
  Full Text via DOI: 10.1002/cne.903620209
- 1994
  
  Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic Receptor Agonists. JOURNAL OF MEDICINAL CHEMISTRY. 37:2774-2782.
  Full Text via DOI: 10.1021/jm00043a016
- 1993
  
  Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. JOURNAL OF MEDICINAL CHEMISTRY. 36:842-847.
  Full Text via DOI: 10.1021/jm00059a008
- 1993
  
  Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs. JOURNAL OF MEDICINAL CHEMISTRY. 36:1893-1901.
  Full Text via DOI: 10.1021/jm00065a012
- 1993
  
  Regional binding of 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP) to muscarinic receptors in rat brain and comparative analysis of minimum energy conformations. NEUROCHEMISTRY INTERNATIONAL. 22:237-247.
  Full Text via DOI: 10.1016/0197-0186(93)90051-6
- 1992
  
  Stereoselective binding and activity of oxotremorine analogs at muscarinic receptors in rat brain. Chirality. 4:463-468.
  Full Text via DOI: 10.1002/chir.530040802
- 1992
  
  Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 187:1389-1394.
  Full Text via DOI: 10.1016/0006-291x(92)90456-u
- 1992
  
  Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2:781-786.
  Full Text via DOI: 10.1016/s0960-894x(00)80531-4
- 1991
  
  Involvement of the septohippocampal cholinergic system in representational memory. BRAIN RESEARCH. 564:66-72.
  Full Text via DOI: 10.1016/0006-8993(91)91352-2
- 1991
  
  Regulation of muscarinic receptors by intrahippocampal injections of gallamine. BRAIN RESEARCH. 564:73-78.
  Full Text via DOI: 10.1016/0006-8993(91)91353-3
- 1990
  
  Biochemical and behavioral evidence for muscarinic autoreceptors in the CNS. BRAIN RESEARCH. 517:195-201.
  Full Text via DOI: 10.1016/0006-8993(90)91026-d
- 1990
  
  Biochemical and behavioral responses of pilocarpine at muscarinic receptor subtypes in the CNS. Comparison with receptor binding and low-energy conformations. BRAIN RESEARCH. 533:232-238.
  Full Text via DOI: 10.1016/0006-8993(90)91344-g
- 1990
  
  Differential coupling between muscarinic receptors and G-proteins in regions of the rat brain. BIOCHEMICAL PHARMACOLOGY. 39:1385-1391.
  Full Text via DOI: 10.1016/0006-2952(90)90016-e
- 1990
  
  Evidence for a preferential involvement of M1 muscarinic receptors in representational memory. NEUROSCIENCE LETTERS. 116:184-189.
  Full Text via DOI: 10.1016/0304-3940(90)90407-z
- 1990
  
  Identification of four brain areas each enriched in a unique muscarinic receptor subtype. LIFE SCIENCES. 46:1051-1058.
  Full Text via DOI: 10.1016/0024-3205(90)90413-l
- 1990
  
  Subtype specificity of the muscarinic receptor-stimulated GTPase response in the rat cortex. NEUROSCIENCE LETTERS. 110:148-154.
  Full Text via DOI: 10.1016/0304-3940(90)90803-h
- 1989
  
  Autoradiographic analyses of agonist binding to muscarinic receptor subtypes. BIOCHEMICAL PHARMACOLOGY. 38:837-850.
  Full Text via DOI: 10.1016/0006-2952(89)90239-6
- 1989
  
  Interaction of amitriptyline with muscarinic receptor subtypes in the rat brain. NEUROCHEMISTRY INTERNATIONAL. 14:447-454.
  Full Text via DOI: 10.1016/0197-0186(89)90034-x
- 1989
  
  Regional differences in the binding of selective muscarinic receptor antagonists in rat brain: comparison with minimum-energy conformations. JOURNAL OF MEDICINAL CHEMISTRY. 32:1164-1172.
  Full Text via DOI: 10.1021/jm00126a004
- 1988
  
  Intrahippocampal injections of gallamine impair learning of a memory task. NEUROSCIENCE LETTERS. 89:367-372.
  Full Text via DOI: 10.1016/0304-3940(88)90554-x
- 1987
  
  Selectivity of pirenzepine in the central nervous system. I. Direct autoradiographic comparison of the regional distribution of pirenzepine and carbamylcholine binding sites. BRAIN RESEARCH. 407:27-36.
  Full Text via DOI: 10.1016/0006-8993(87)91216-9
- 1987
  
  Selectivity of pirenzepine in the central nervous system. II. Differential effects of pirenzepine and scopolamine on performance of a representational memory task. BRAIN RESEARCH. 407:37-45.
  Full Text via DOI: 10.1016/0006-8993(87)91217-0
- 1987
  
  Selectivity of pirenzepine in the central nervous system. III. Differential effects of multiple pirenzepine and scopolamine administrations on muscarinic receptors as measured autoradiographically. BRAIN RESEARCH. 407:46-54.
  Full Text via DOI: 10.1016/0006-8993(87)91218-2
- 1986
  
  Regional distribution of muscarinic receptors preferring gallamine in the rat brain. BIOCHEMICAL PHARMACOLOGY. 35:4171-4176.
  Full Text via DOI: 10.1016/0006-2952(86)90692-1
Editorial Material (Web of Science)
- 1986
  
  Multiple muscarinic receptors in the CNS. BIOCHEMICAL PHARMACOLOGY. 3895-3901.
  Full Text via DOI: 10.1016/0006-2952(86)90001-8
Meeting Abstract (Web of Science)
- 2011
  
  Structure activity relationships in a series of potential allosteric muscarinic ligands. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 1999
  
  Activity of selective muscarinic agonists at human M1 receptors expressed at varying levels in A9 L cells. LIFE SCIENCES. 571.
  Full Text via DOI: 10.1016/s0024-3205(99)90498-8
- 1999
  
  Mutant M1 muscarinic receptors with enhanced agonist activity. LIFE SCIENCES. 563.
  Full Text via DOI: 10.1016/s0024-3205(99)90481-2
- 1999
  
  Mutant M1 muscarinic receptors with increased agonist affinity and G protein coupling. LIFE SCIENCES. 563.
  Full Text via DOI: 10.1016/s0024-3205(99)90482-4
- 1995
  
  Neurochemical evaluation of the selective m1 muscarinic receptor agonist CDD-0097-A. LIFE SCIENCES. 1005.
  Full Text via DOI: 10.1016/0024-3205(95)93723-r
- 1995
  
  Selectivity of 2-amino-5-alkoxycarbonyl-3,4,5,6-tetrahydropyridines and 2-amino-5-alkoxycarbonyl-1,4,5,6-tetrahydropyrimidines for muscarinic receptor subtypes. LIFE SCIENCES. 1007.
  Full Text via DOI: 10.1016/0024-3205(95)93726-u
- 1995
  
  Synthesis and structure-activity relationships of novel amidine derivatives as muscarinic receptor subtype-selective agonists. LIFE SCIENCES. 1005.
  Full Text via DOI: 10.1016/0024-3205(95)93722-q
Review Article (Web of Science)
- 2008
  
  Electrochemical detection of acetylcholine and choline: application to the quantitative nonradiochemical evaluation of choline transport. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 651-662.
  Full Text via DOI: 10.1007/s00216-008-2307-2

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William S Messer

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