William T Gunning
- Director, Electron Microscopy, Pathology , College of Medicine and Life Sciences
Contact Info
Publications
selected publications
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Article (Web of Science)
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2022Medich Giant Platelet Syndrome: An Evolving Qualitative and Quantitative Platelet Disorder. HEMATOLOGY REPORTS. 14:349-357.Full Text via DOI: 10.3390/hematolrep14040049 PMID: 36547233
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2022Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome. CELLS. 11.Full Text via DOI: 10.3390/cells11050774 PMID: 35269395
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2022Age-related GSK3β overexpression drives podocyte senescence and glomerular aging. Journal of Clinical Investigation. 132.Full Text via DOI: 10.1172/jci141848
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2021An Investigation of ABO Blood Type and the Platelet Delta Granule Storage Pool. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS. 27.Full Text via DOI: 10.1177/10760296211068818 PMID: 34939438
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2021Platelet Aggregation Assays Do Not Reliably Diagnose Platelet Delta Granule Storage Pool Deficiency. JOURNAL OF HEMATOLOGY. 10:196-201.Full Text via DOI: 10.14740/jh832 PMID: 34527116
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2021Negative Fat Pad Biopsy in Systemic AL: A Case Report Analyzing the Preferred Amyloidosis Screening Test. DISEASES. 9.Full Text via DOI: 10.3390/diseases9020040 PMID: 34071274
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2021A Francisella tularensis L,D-carboxypeptidase plays important roles in cell morphology, envelope integrity, and virulence. MOLECULAR MICROBIOLOGY.Full Text via DOI: 10.1111/mmi.14685 PMID: 33469978
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2021Inflammatory Biomarkers in Postural Orthostatic Tachycardia Syndrome with Elevated G-Protein-Coupled Receptor Autoantibodies. JOURNAL OF CLINICAL MEDICINE. 10.Full Text via DOI: 10.3390/jcm10040623 PMID: 33562074
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2020A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency. JOURNAL OF CLINICAL MEDICINE. 9.Full Text via DOI: 10.3390/jcm9061734 PMID: 32512725
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2019ZRSR2 mutation in a child with refractory macrocytic anemia and Down Syndrome. PEDIATRIC HEMATOLOGY AND ONCOLOGY. 36:236-243.Full Text via DOI: 10.1080/08880018.2019.1621969 PMID: 31361176
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2019Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 8.Full Text via DOI: 10.1161/jaha.119.013602
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2018Assessment of the Stability of von Willebrand Profile Clotting Factors and Platelet Dense Granule Testing Following Air Transport. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS. 24:1261-1266.Full Text via DOI: 10.1177/1076029618794298
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2018MYH9-macrothrombocytopenia caused by a novel variant (E1421K) initially presenting as apparent neonatal alloimmune thrombocytopenia. PEDIATRIC BLOOD & CANCER. 65.Full Text via DOI: 10.1002/pbc.26949
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2017Peritoneal Deciduoid Mesothelioma: An Unusual Presentation Complicating an Already Challenging Diagnosis. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. 25:352-356.Full Text via DOI: 10.1177/1066896916688084
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2017A Case Report of in Utero Williams Syndrome Arterial Malformation. FETAL AND PEDIATRIC PATHOLOGY. 36:452-456.Full Text via DOI: 10.1080/15513815.2017.1379040
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2016Postural orthostatic tachycardia syndrome is associated with platelet storage pool deficiency. MEDICINE. 95.Full Text via DOI: 10.1097/MD.0000000000004849
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2016FmvB: A Francisella tularensis Magnesium-Responsive Outer Membrane Protein that Plays a Role in Virulence. PLOS ONE. 11.Full Text via DOI: 10.1371/journal.pone.0160977
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2016Postural orthostatic tachycardia syndrome is associated with platelet storage pool deficiency. MEDICINE. 95:e4849.Full Text via DOI: 10.1097/md.0000000000004849
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2015Gastro-Enteropancreatic Neuroendocrine Tumor Cell Dynamics in Liver Microvasculature. MICROSCOPY AND MICROANALYSIS. 21:655-665.Full Text via DOI: 10.1017/S1431927615000392
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2015A histological and functional description of the tissue causing chronic postthrombotic venous obstruction. THROMBOSIS RESEARCH. 135:882-887.Full Text via DOI: 10.1016/j.thromres.2015.02.026
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2015Gastro-Enteropancreatic Neuroendocrine Tumor Cell Dynamics in Liver Microvasculature. MICROSCOPY AND MICROANALYSIS. 21:655-665.Full Text via DOI: 10.1017/s1431927615000392
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2014THE IMPACT OF DIFFERENT SCORING RUBRICS FOR GRADING VIRTUAL PATIENT-BASED EXAMS. JOURNAL OF EDUCATIONAL COMPUTING RESEARCH. 50:97-118.Full Text via DOI: 10.2190/EC.50.1.e
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2014The Impact of Different Scoring Rubrics for Grading Virtual Patient-Based Exams. JOURNAL OF EDUCATIONAL COMPUTING RESEARCH. 50:97-118.Full Text via DOI: 10.2190/ec.50.1.e
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2013The Medich giant platelet syndrome: Two new cases. PLATELETS. 24:107-112.Full Text via DOI: 10.3109/09537104.2012.671980
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2013Clinical and laboratory characteristics of adolescents with platelet function disorders and heavy menstrual bleeding. Experimental Hematology & Oncology. 2:3.Full Text via DOI: 10.1186/2162-3619-2-3
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2013Methamphetamine causes acute hyperthermia‐dependent liver damage. PHARMACOLOGY RESEARCH & PERSPECTIVES. 1:prp2.8.Full Text via DOI: 10.1002/prp2.8
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2012Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II Signaling within Hippocampal Glutamatergic Postsynapses during Flurazepam Withdrawal. NEURAL PLASTICITY.Full Text via DOI: 10.1155/2012/405926
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2012Virtual Patients for assessment of medical student ability to integrate clinical and laboratory data to develop differential diagnoses: Comparison of results of exams with/without time constraints. MEDICAL TEACHER. 34:E222-E228.Full Text via DOI: 10.3109/0142159X.2012.642830
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2012Virtual Patients for assessment of medical student ability to integrate clinical and laboratory data to develop differential diagnoses: Comparison of results of exams with/without time constraints. MEDICAL TEACHER. 34:e222-e228.Full Text via DOI: 10.3109/0142159x.2012.642830
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2011A novel aza-anthrapyrazole blocks the progression of experimental autoimmune encephalomyelitis after the priming of autoimmunity. CLINICAL IMMUNOLOGY. 141:304-316.Full Text via DOI: 10.1016/j.clim.2011.08.009
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2011Collapsin Response Mediator Protein-2: An Emerging Pathologic Feature and Therapeutic Target for Neurodisease Indications. MOLECULAR NEUROBIOLOGY. 43:180-191.Full Text via DOI: 10.1007/s12035-011-8166-4
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2010Polyethylene Glycol Modified-Albumin Enhances the Cold Preservation Properties of University of Wisconsin Solution in Rat Liver and a Hepatocyte Cell Line. JOURNAL OF SURGICAL RESEARCH. 164:95-104.Full Text via DOI: 10.1016/j.jss.2009.03.030
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2010Microscopic polyangiitis triggered by recurrent methicillin-resistant Staphylococcus aureus bacteremia. INTERNATIONAL UROLOGY AND NEPHROLOGY. 42:821-824.Full Text via DOI: 10.1007/s11255-009-9652-8
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2009Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 296:F839-F846.Full Text via DOI: 10.1152/ajprenal.90370.2008
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2009Platelet-dense granule deficiency causes postoperative hemorrhage in patients receiving enoxaparin: a novel observation with dramatic clinical implications. AMERICAN JOURNAL OF SURGERY. 197:365-369.Full Text via DOI: 10.1016/j.amjsurg.2008.11.006
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2009Regulation of Folate Receptor Internalization by Protein Kinase C α. BIOCHEMISTRY. 48:8249-8260.Full Text via DOI: 10.1021/bi900565t
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2008Increased AMPA Receptor GluR1 Subunit Incorporation in Rat Hippocampal CA1 Synapses During Benzodiazepine Withdrawal. JOURNAL OF COMPARATIVE NEUROLOGY. 511:832-846.Full Text via DOI: 10.1002/cne.21866
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2008Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase. JOURNAL OF CELL BIOLOGY. 182:1153-1169.Full Text via DOI: 10.1083/jcb.200712022
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2008Visualizing form and function in organotypic slices of the adult mouse parotid gland. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 295:G629-G640.Full Text via DOI: 10.1152/ajpgi.90217.2008
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2008Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia. JOURNAL OF COMPARATIVE NEUROLOGY. 508:867-878.Full Text via DOI: 10.1002/ene.21719
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2008Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia. JOURNAL OF COMPARATIVE NEUROLOGY. 508:867-878.Full Text via DOI: 10.1002/cne.21719
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2007Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21. PHYSIOLOGICAL GENOMICS. 30:322-334.Full Text via DOI: 10.1152/physiolgenomics.00001.2007
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2007Bmi-1 Is Essential for the Tumorigenicity of Neuroblastoma Cells. AMERICAN JOURNAL OF PATHOLOGY. 170:1370-1378.Full Text via DOI: 10.2353/ajpath.2007.060754
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2007Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT). CARCINOGENESIS. 28:124-129.Full Text via DOI: 10.1093/carcin/bgl136
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2006Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes. JOURNAL OF CELL SCIENCE. 119:1219-1232.Full Text via DOI: 10.1242/jcs.02833
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2006Migraine Is Associated With Menorrhagia and Endometriosis. HEADACHE. 46:422-428.Full Text via DOI: 10.1111/j.1526-4610.2006.00290.x
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2006NF-κB2 Is Required for the Control of Autoimmunity by Regulating the Development of Medullary Thymic Epithelial Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:38617-38624.Full Text via DOI: 10.1074/jbc.m606705200
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2006Prevention of mouse lung tumors by targretin. International Journal of Cancer. 118:2359-2362.Full Text via DOI: 10.1002/ijc.21618
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2005Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 288:C721-C729.Full Text via DOI: 10.1152/ajpcell.00237.2004
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2005CHEMOPREVENTION: MOUSE COLON AND LUNG TUMOR BIOASSAY AND MODULATION OF DNA METHYLATION AS A BIOMARKER. Experimental Lung Research. 31:145-163.Full Text via DOI: 10.1080/01902140490495534
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2005Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[ a ]anthracene (DMBA) coated suture. CARCINOGENESIS. 26:951-957.Full Text via DOI: 10.1093/carcin/bgi039
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2005Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells. KIDNEY INTERNATIONAL. 67:1868-1877.Full Text via DOI: 10.1111/j.1523-1755.2005.00285.x
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2002Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors. MOLECULAR CARCINOGENESIS. 35:93-102.Full Text via DOI: 10.1002/mc.10078
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2002Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells. KIDNEY INTERNATIONAL. 62:2118-2125.Full Text via DOI: 10.1046/j.1523-1755.2002.00672.x
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2002Evidence for Segregation of Heterologous GPI-anchored Proteins into Separate Lipid Rafts within the Plasma Membrane. JOURNAL OF MEMBRANE BIOLOGY. 189:35-43.Full Text via DOI: 10.1007/s00232-002-1002-z
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2002Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis. 23:1185-1192.Full Text via DOI: 10.1093/carcin/23.7.1185
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2002Protein Micelles from Lipoxygenase 3. BIOMACROMOLECULES. 3:649-654.Full Text via DOI: 10.1021/bm010149i
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2001Neutrophils injure cultured skeletal myotubes. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 281:C335-C341.Full Text via DOI: 10.1152/ajpcell.2001.281.1.c335
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2000A Brief Review of Transmission Electron Microscopy and Applications in Pathology. Journal of Histotechnology. 23:237-246.Full Text via DOI: 10.1179/his.2000.23.3.237
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2000Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells. BLOOD. 95:1283-1292.Full Text via DOI: 10.1182/blood.v95.4.1283.004k44_1283_1292
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2000CHEMOPREVENTION OF VINYL CARBAMATE-INDUCED LUNG TUMORS IN STRAIN A MICE. Experimental Lung Research. 26:757-772.Full Text via DOI: 10.1080/01902140150216800
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2000Scanning electron microscopic examination of the egg of the pubic louse (Anoplura: Pthirus pubis). INTERNATIONAL JOURNAL OF DERMATOLOGY. 39:201-202.Full Text via DOI: 10.1046/j.1365-4362.2000.00901.x
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1999Infection by Rhodococcus equi in a patient with AIDS: histological appearance mimicking Whipple's disease and Mycobacterium avium- intracellulare infection. Journal of Clinical Pathology. 52:68-71.Full Text via DOI: 10.1136/jcp.52.1.68
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1999Scanning Electron Microscopy of Human Head Louse (Anoplura: Pediculidae) Egg and its Clinical Ramifications. Journal of Medical Entomology. 36:454-456.Full Text via DOI: 10.1093/jmedent/36.4.454
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1999Strain Differences in Neointimal Hyperplasia in the Rat. CIRCULATION RESEARCH. 84:1252-1257.Full Text via DOI: 10.1161/01.res.84.11.1252
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1997Adrenocortical oncocytoma: two case reports and review of literature. UROLOGY. 49:624-628.Full Text via DOI: 10.1016/s0090-4295(96)00543-2
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1997Clustering of GPI-Anchored Folate Receptor Independent of Both Cross-Linking and Association with Caveolin. JOURNAL OF MEMBRANE BIOLOGY. 159:137-147.Full Text via DOI: 10.1007/s002329900277
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1996Antioxidant enzyme gene transcription in copper-deficient rat liver. FREE RADICAL BIOLOGY AND MEDICINE. 21:233-240.Full Text via DOI: 10.1016/0891-5849(96)00029-9
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1996Axon and Ganglion Cell Injury in Rabbits after Percutaneous Trigeminal Balloon Compression. NEUROSURGERY. 38:993-1004.Full Text via DOI: 10.1097/00006123-199605000-00028
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1994Ki-ras mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—initiated and butylated hydroxytoluene—promoted lung tumors in A/J mice. MOLECULAR CARCINOGENESIS. 11:42-48.Full Text via DOI: 10.1002/mc.2940110108
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1992Autosomal recessive neurodegenerative disorder with trichorrhexis invaginata and ectodermal dysplasia. PEDIATRIC NEUROLOGY. 8:469-472.Full Text via DOI: 10.1016/0887-8994(92)90012-n
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1992Mutagenesis of the K-ras protooncogene in mouse lung tumors induced by N-ethyl-N-nitrosourea or N-nitrosodiethylamine. CARCINOGENESIS. 13:1583-1586.Full Text via DOI: 10.1093/carcin/13.9.1583
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1991A human bronchial epithelial cell strain with unusualin vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection. International Journal of Cancer. 48:764-773.Full Text via DOI: 10.1002/ijc.2910480522
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1991Carnitine deficiency associated with ornithine transcarbamylase deficiency. PEDIATRIC NEUROLOGY. 7:196-199.Full Text via DOI: 10.1016/0887-8994(91)90084-x
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1991Glyceraldehyde-3-Phosphate Dehydrogenase and Other Enzymatic Activity in Normal Mouse Lung and in Lung Tumors. Experimental Lung Research. 17:255-261.Full Text via DOI: 10.3109/01902149109064416
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1991Strain A/J Mouse Lung Adenoma Growth Patterns Vary When Induced by Different Carcinogens. Toxicologic Pathology. 19:168-175.Full Text via DOI: 10.1177/019262339101900212
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1989Metabolic Studies of Carnitine in a Child with Propionic Acidemia. Pediatric Research. 26:63-66.Full Text via DOI: 10.1203/00006450-198907000-00018
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1984The usefulness of glutaraldehyde-carbohydrazide copolymerization in biological specimen stabilization for scanning electron microscopy. Journal of Electron Microscopy Technique. 1:131-140.Full Text via DOI: 10.1002/jemt.1060010203
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1982In vitro transformation of rat esophageal epithelial cells with N-nitrosobenzylmethylamine. CARCINOGENESIS. 3:629-634.Full Text via DOI: 10.1093/carcin/3.6.629
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Conference Poster (Faculty180)
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Editorial Material (Web of Science)
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2019A Case of Chronic Thrombocytopenia in a 17-Year-Old Female. LABMEDICINE. 406-420.Full Text via DOI: 10.1093/labmed/lmz013 PMID: 31228350
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2009“Pseudo-Sickle” Cell Anemia. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 292.Full Text via DOI: 10.1097/maj.0b013e31819f1ec1
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Meeting Abstract (Web of Science)
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2021Unique case of 19p13 syndrome with storage pool disease. AMERICAN JOURNAL OF CLINICAL PATHOLOGY. S104-S104.Full Text via DOI: 10.1093/ajcp/aqab191.221
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2016Nemaline Rods: A Rare Case of Restrictive Cardiomyopathy. JOURNAL OF CARDIAC FAILURE. S55-S55.
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2016Diagnosis of platelet disorders despite normal platelet aggregations. HAEMOPHILIA. 125-125.
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2016Vinyl Carbamate Induces Membranoproliferative Glomerulonephritis in an In-Bred Murine Bioassay Model. LABORATORY INVESTIGATION. 412A-412A.
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2016Vinyl Carbamate Induces Membranoproliferative Glomerulonephritis in an In-Bred Murine Bioassay Model. MODERN PATHOLOGY. 412A-412A.
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2016Nemaline Rods: A Rare Case of Restrictive Cardiomyopathy. JOURNAL OF CARDIAC FAILURE. S55.Full Text via DOI: 10.1016/j.cardfail.2016.06.162
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2015Platelet aggregation assays do not reliably diagnose platelet storage pool deficiency. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 47-47.
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2013The platelet delta granule storage pool increases in pregnancy. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 905-905.
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2010Treatment with a novel aza-anthrapyrazole prevents myelin oligon-dentdrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. MULTIPLE SCLEROSIS JOURNAL. 1005-1005.
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2007Is the platelet involved in the etiology of neurocardiogenic syncope?. BLOOD. 945A-945A.
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2007Is the Platelet Involved in the Etiology of Neurocardiogenic Syncope?.. BLOOD. 3220-3220.Full Text via DOI: 10.1182/blood.v110.11.3220.3220
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1985Light and electron microscopy of peripheral blood. Micron and Microscopica Acta. 195-198.Full Text via DOI: 10.1016/0739-6260(85)90067-x
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1984Cellular origin of urethane-induced lung tumors in strain a mice. Micron and Microscopica Acta. 103-104.Full Text via DOI: 10.1016/0739-6260(84)90011-x
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1983Intranuclear tubular inclusions and cytoplasmic bodies in a patient with chronic interstitial fibrosis. Micron (1969). 81-82.Full Text via DOI: 10.1016/0047-7206(83)90038-9
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1983Squamos differentiation in a metastatic clear cell tumor. Micron (1969). 77-78.Full Text via DOI: 10.1016/0047-7206(83)90036-5
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1981Ultrastructural observations of mouse hepatocytes in primary culture. Micron (1969). 209-210.Full Text via DOI: 10.1016/0047-7206(81)90069-8
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Note (Web of Science)
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1982Utilization of aminoplastics as an alternative biological SEM specimen preparation technique. Micron (1969). 65-66.Full Text via DOI: 10.1016/0047-7206(82)90145-5
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Review Article (Web of Science)
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2016Something Old, New, Borrowed, Blue: Anthracenedione Agents for Treatment of Multiple Sclerosis. CLINICAL NEUROPHARMACOLOGY. 102-111.Full Text via DOI: 10.1097/WNF.0000000000000137
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2016Something Old, New, Borrowed, Blue. CLINICAL NEUROPHARMACOLOGY. 102-111.Full Text via DOI: 10.1097/wnf.0000000000000137
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2004Classification of Proliferative Pulmonary Lesions of the Mouse. CANCER RESEARCH. 2307-2316.Full Text via DOI: 10.1158/0008-5472.can-03-3376
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Contact
full name
- William T Gunning
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Cumulative publications in Scholars@UToledo
research areas
- Biochemistry & Molecular Biology
- Cardiovascular System & Cardiology
- Cell Biology
- Education & Educational Research
- Gastroenterology & Hepatology
- General & Internal Medicine
- Genetics & Heredity
- Health Care Sciences & Services
- Hematology
- Immunology
- Materials Science
- Microbiology
- Microscopy
- Neurosciences & Neurology
- Oncology
- Pathology
- Pediatrics
- Pharmacology & Pharmacy
- Physiology
- Research & Experimental Medicine
- Science & Technology - Other Topics
- Surgery
- Urology & Nephrology
- Zoology