Welivitiya K Ajith Karunarathne
- Associate Professor, Chemistry & Biochemistry , College of Natural Sciences and Mathematics
Publications
selected publications
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Article (Faculty180)
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2021A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy.. Molecular Biology of the Cell.. 32:1446-1458.
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2021Dissociation of the G protein βγ from the Gq-PLCβ complex partially attenuates PIP2 hydrolysis.. Journal of Biological Chemistry.
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2021Subtype-dependent regulation of Gβγ signalling.. Cellular Signalling.
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2020A C-peptide complex with albumin and Zn(2+) increases measurable GLUT1 levels in membranes of human red blood cells.. Nature Scientific Reports .
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2020Blue light-triggered photochemistry and cytotoxicity of retinal. Cellular Signalling. 69.
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2020Microcystins: Biogenesis, Toxicity, Analysis, and Control. LID - 10.1021/acs.chemrestox.0c00164 [doi]. Chemical Research in Toxicology. 34:22.
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2019Statins Perturb Gβγ Signaling and Cell Behavior in a Gγ Subtype Dependent Manner.. Molecular Pharmacology. 95:361-375.
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2019G protein alpha q exerts expression level-dependent distinct signaling paradigms. Cellular Signalling. 58:34-43.
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2019Optical approaches for single-cell and subcellular analysis of GPCRâG protein signaling. Analytical and Bioanalytical Chemistry. 411:4481-4508.
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2018Blue light excited retinal intercepts cellular signaling. Scientific Reports. 8:10207.
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2018Blue light-excited retinal delocalizes plasma membrane bound PIP2 and triggers stress responses challenging the cellular integrity. The FASEB Journal. 32:533.36-533.36.
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2018
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2018G protein γ (Gγ) subtype dependent targeting of GRK2 to M3 receptor by Gβγ. Biochemical and Biophysical Research Communications. 503:165-170.
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2018Gγ identity dictates efficacy of Gβγ signaling and macrophage migration.. Journal of Biological Chemistry. 293:2974-2989.
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2018Melanopsin (Opn4) utilizes Gαi and Gβγ as major signal transducers. Journal of Cell Science. 131.
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2017Comparison of Calcium Dynamics and Specific Features for G Protein–Coupled Receptor–Targeting Drugs Using Live Cell Imaging and Automated Analysis . SLAS DISCOVERY: Advancing Life Sciences R&D. 22:848-858.
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2017Two independent but synchronized Gβγ subunit–controlled pathways are essential for trailing-edge retraction during macrophage migration. Journal of Biological Chemistry. 292:17482-17495.
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2016Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Science Signaling. 9:ra71.
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2016Reversible G Protein βγ9 Distribution-Based Assay Reveals Molecular Underpinnings in Subcellular, Single-Cell, and Multicellular GPCR and G Protein Activity. Analytical Chemistry. 88:11450-11459.
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2015Subcellular optogenetics – controlling signaling and single-cell behavior. Journal of Cell Science. 128:15.
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2015Subcellular optogenetics--controlling signaling and single-cell behavior. J Cell Sci. jcs.
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2014A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations. Biophysical journal. 107:242.
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2013Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. Proceedings of the National Academy of Sciences. 201220755.
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2013Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension. Proceedings of the National Academy of Sciences. 201220697.
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2013The structure of dynamic GPCR signaling networks. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 6:115.
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2012All G protein betagamma complexes are capable of translocation on receptor activation. Biochemical and biophysical research communications. 421:605.
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2012G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes. Proceedings of the National Academy of Sciences. 109:E3568.
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2012Measuring P2X1 receptor activity in washed platelets in the absence of exogenous apyrase. Analytical Methods. 4:101.
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2011Alteration of Golgi structure in senescent cells and its regulation by a G protein gamma subunit. Cellular signalling. 23:785.
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2010Hydroxyurea stimulates the release of ATP from rabbit erythrocytes through an increase in calcium and nitric oxide production. European journal of pharmacology. 645:32.
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2010Regulation of Golgi structure and secretion by receptor-induced G protein beta gamma complex translocation. Proceedings of the National Academy of Sciences. 107:11417.
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2010Use of the red blood cell as a simple drug target and diagnostic by manipulating and monitoring its ability to release adenosine triphosphate (ATP). Pure and Applied Chemistry. 82:1623.
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2009The dual nature of extracellular ATP as a concentration-dependent platelet P2X1 agonist and antagonist. Integrative Biology. 1:655.
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2007Fluorescence determination of nitric oxide production in stimulated and activated platelets. Analytical chemistry. 79:2421.
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Article (Web of Science)
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2021Subtype-dependent regulation of G beta gamma signalling. CELLULAR SIGNALLING. 82.Full Text via DOI: 10.1016/j.cellsig.2021.109947 PMID: 33582184
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2021Dissociation of the G protein beta gamma from the Gq-PLC beta complex partially attenuates PIP2 hydrolysis. JOURNAL OF BIOLOGICAL CHEMISTRY. 296.Full Text via DOI: 10.1016/j.jbc.2021.100702 PMID: 33901492
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2021A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. MOLECULAR BIOLOGY OF THE CELL. mbc.E20-11-0750.Full Text via DOI: 10.1091/mbc.e20-11-0750
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2020A C-peptide complex with albumin and Zn2+ increases measurable GLUT1 levels in membranes of human red blood cells. SCIENTIFIC REPORTS. 10.Full Text via DOI: 10.1038/s41598-020-74527-6 PMID: 33060722
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2020Blue light-triggered photochemistry and cytotoxicity of retinal. CELLULAR SIGNALLING. 69.Full Text via DOI: 10.1016/j.cellsig.2020.109547 PMID: 31982549
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2019G protein alpha q exerts expression level-dependent distinct signaling paradigms. CELLULAR SIGNALLING. 58:34-43.Full Text via DOI: 10.1016/j.cellsig.2019.02.006 PMID: 30849518
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2019Statins Perturb G beta gamma Signaling and Cell Behavior in a G gamma Subtype Dependent Manner. MOLECULAR PHARMACOLOGY. 95:361-375.Full Text via DOI: 10.1124/mol.118.114710
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2018Confocal Imaging and k-Means Clustering of GABA(B) and mGluR Mediated Modulation of Ca2+ Spiking in Hippocampal Neurons. ACS CHEMICAL NEUROSCIENCE. 9:3094-3107.Full Text via DOI: 10.1021/acschemneuro.8b00297
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2018G protein gamma (G gamma) subtype dependent targeting of GRK2 to M3 receptor by G beta gamma. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 503:165-170.Full Text via DOI: 10.1016/j.bbrc.2018.05.204
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2018Blue light excited retinal intercepts cellular signaling. SCIENTIFIC REPORTS. 8.Full Text via DOI: 10.1038/s41598-018-28254-8
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2018Melanopsin (Opn4) utilizes G alpha(i) and G beta gamma as major signal transducers. JOURNAL OF CELL SCIENCE. 131.Full Text via DOI: 10.1242/jcs.212910
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2018G gamma identity dictates efficacy of G beta gamma signaling and macrophage migration. JOURNAL OF BIOLOGICAL CHEMISTRY. 293:2974-2989.Full Text via DOI: 10.1074/jbc.RA117.000872
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2018Gγ identity dictates efficacy of Gβγ signaling and macrophage migration. JOURNAL OF BIOLOGICAL CHEMISTRY. 293:2974-2989.Full Text via DOI: 10.1074/jbc.ra117.000872
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2017Two independent but synchronized G beta gamma subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration. JOURNAL OF BIOLOGICAL CHEMISTRY. 292:17482-17495.Full Text via DOI: 10.1074/jbc.M117.787838
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2017Comparison of Calcium Dynamics and Specific Features for G Protein-Coupled Receptor-Targeting Drugs Using Live Cell Imaging and Automated Analysis. SLAS DISCOVERY. 22:848-858.Full Text via DOI: 10.1177/2472555217693378
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2017Two independent but synchronized Gβγ subunit–controlled pathways are essential for trailing-edge retraction during macrophage migration. JOURNAL OF BIOLOGICAL CHEMISTRY. 292:17482-17495.Full Text via DOI: 10.1074/jbc.m117.787838
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2016Reversible G Protein beta gamma 9 Distribution-Based Assay Reveals Molecular Underpinnings in Subcellular, Single-Cell, and Multicellular GPCR and G Protein Activity. ANALYTICAL CHEMISTRY. 88:11450-11459.Full Text via DOI: 10.1021/acs.analchem.6b02512
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2016Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. SCIENCE SIGNALING. 9.Full Text via DOI: 10.1126/scisignal.aaf1047
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2015Subcellular optogenetics - controlling signaling and single-cell behavior. JOURNAL OF CELL SCIENCE. 128:15-25.Full Text via DOI: 10.1242/jcs.154435
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2014A G-Protein Subunit Translocation Embedded Network Motif Underlies GPCR Regulation of Calcium Oscillations. BIOPHYSICAL JOURNAL. 107:242-254.Full Text via DOI: 10.1016/j.bpj.2014.05.020
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2014Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling. Neuron. 84:821-834.Full Text via DOI: 10.1016/j.neuron.2014.10.003
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2014The structure of dynamic GPCR signaling networks. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 6:115-123.Full Text via DOI: 10.1002/wsbm.1249
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2013Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110.Full Text via DOI: 10.1073/pnas.1220755110
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2013Optically triggering spatiotemporally confined GPCR activity in a cell and programming neurite initiation and extension. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110.Full Text via DOI: 10.1073/pnas.1220697110
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2012All G protein βγ complexes are capable of translocation on receptor activation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 421:605-611.Full Text via DOI: 10.1016/j.bbrc.2012.04.054
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2012G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109.Full Text via DOI: 10.1073/pnas.1205345109
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2012Measuring P2X1 receptor activity in washed platelets in the absence of exogenous apyrase. ANALYTICAL METHODS. 4:101-105.Full Text via DOI: 10.1039/c1ay05530e
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2011Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit. CELLULAR SIGNALLING. 23:785-793.Full Text via DOI: 10.1016/j.cellsig.2011.01.001
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2010Hydroxyurea stimulates the release of ATP from rabbit erythrocytes through an increase in calcium and nitric oxide production. EUROPEAN JOURNAL OF PHARMACOLOGY. 645:32-38.Full Text via DOI: 10.1016/j.ejphar.2010.07.012
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2010Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107:11417-11422.Full Text via DOI: 10.1073/pnas.1003042107
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2010Use of the red blood cell as a simple drug target and diagnostic by manipulating and monitoring its ability to release adenosine triphosphate (ATP). PURE AND APPLIED CHEMISTRY. 82:1623-1634.Full Text via DOI: 10.1351/pac-con-10-02-10
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2009The dual nature of extracellular ATP as a concentration-dependent platelet P2X1 agonist and antagonist. Integrative Biology. 1:655.Full Text via DOI: 10.1039/b909873a
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2007Metal-activated C-peptide facilitates glucose clearance and the release of a nitric oxide stimulus via the GLUT1 transporter. DIABETOLOGIA. 51:175-182.Full Text via DOI: 10.1007/s00125-007-0853-3
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Book Chapter (Web of Science)
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2018Regulation of G Protein beta gamma Signaling. G PROTEIN-COUPLED RECEPTORS: EMERGING PARADIGMS IN ACTIVATION, SIGNALING AND REGULATION, PT B. 133-191.Full Text via DOI: 10.1016/bs.ircmb.2018.02.008
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2017Measurement of GPCR-G protein activity in living cells. G PROTEIN-COUPLED RECEPTORS, 2ND EDITION, PT A. 1-25.Full Text via DOI: 10.1016/bs.mcb.2017.07.008
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Chapter (Faculty180)
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2018Chapter Five - Regulation of G Protein βγ Signaling. G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part B. Academic Press. 133-191.
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2017Chapter 1 - Measurement of GPCR-G protein activity in living cells. G Protein-Coupled Receptors Part A. Academic Press. 1-25.
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Conference Poster (Faculty180)
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Correction (Web of Science)
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2020Blue light-triggered photochemistry and cytotoxicity of retinal cellular signalling (vol 69, 109,547, 2020). CELLULAR SIGNALLING.Full Text via DOI: 10.1016/j.cellsig.2020.109667 PMID: 32418778
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Presentation (Faculty180)
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2019
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Press (Faculty180)
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2018Press and media reports on our published research in Blue Light - Retinal and Cytotoxicity. USA TODAY, FORBES, THE TELEGRAPH, NEWSWEEK, THE GUARDIAN ETC...
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Proceedings (Faculty180)
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Proceedings Paper (Web of Science)
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2015Segmentation of Neuron and Measurement of Optically Programed Neurite Growth: Fast Automation via Bayesian Thresholding. 2015 7TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER). 996-999.
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Review Article (Web of Science)
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2020Microcystins: Biogenesis, Toxicity, Analysis, and Control. CHEMICAL RESEARCH IN TOXICOLOGY. 2225-2246.Full Text via DOI: 10.1021/acs.chemrestox.0c00164 PMID: 32614166
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2019Optical approaches for single-cell and subcellular analysis of GPCR-G protein signaling. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 4481-4508.Full Text via DOI: 10.1007/s00216-019-01774-6 PMID: 30927013
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- Welivitiya K Ajith Karunarathne
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