Sucheck, Steve J

Steve J Sucheck
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Positions

Professor, Chemistry & Biochemistry , College of Natural Sciences and Mathematics

Contact Info

Steve.Sucheck@utoledo.edu

https://sucheckgroup.com/

selected publications

Article (Faculty180)
- 2022
  
  Synthesis and evaluation of marine natural product-inspired meroterpenoids with selective activity toward dormant Mycobacterium tuberculosis. ACS omega. 7:23487.
- 2022
  
  Synthesis of C7/C8-cyclitols and C7N-aminocyclitols from maltose and X-ray crystal structure of Streptomyces coelicolor GlgEI V279S in a complex with an amylostatin GXG?like derivative. Frontiers in Chemistry. 10.
- 2021
  
  Stereoselective synthesis of a 4-⍺-glucoside of valienamine and its X-ray structure in complex with Streptomyces coelicolor GlgE1-V279S. Scientific reports. 11:13413.
- 2020
  
  Neuroprotective and Anti-neuroinflammatory Properties of Ebselen Derivatives and Their Potential to Inhibit Neurodegeneration. ACS chemical neuroscience. 11:3008-3016.
- 2019
  
  Development of a bioconjugate platform for modifying the immune response of autoreactive cytotoxic T lymphocytes involved in type 1 diabetes. Bioconj. Chem.. 30:2049–2059.
- 2018
  
  Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker. RSC advances. 8:41612-41619.
- 2017
  
  Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives. Acs Infectious Diseases. 3:378-387.
- 2017
  
  Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S. Organic & Biomolecular Chemistry. 15:3884-3891.
- 2016
  
  Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry. 14:6119-6133.
- 2016
  
  Synthesis of a Liposomal MUC1 Glycopeptide-Based Immunotherapeutic and Evaluation of the Effect of L-Rhamnose Targeting on Cellular Immune Responses. Bioconjugate Chemistry. 27:110-120.
- 2016
  
  Targeting the trehalose utilization pathways of Mycobacterium tuberculosis. Medchemcomm. 7:69-85.
- 2015
  
  Synthesis and inhibition studies of a transition-state inhibitor for Mycobacterium tuberculosis GlgE. Abstracts of Papers of the American Chemical Society. 249.
- 2015
  
  Synthesis of 2-deoxy-2,2-difluoro-alpha-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S. Organic & Biomolecular Chemistry. 13:7542-7550.
- 2014
  
  Bio-based bisfuran: synthesis, crystal structure, and low molecular weight amorphous polyester. Tetrahedron Letters. 55:4141-4145.
- 2014
  
  Biobased bis-furan polymer: Crystal structure of a bisfuran diol (BFD) and synthesis of a low molecular weight amorphous polyester. Abstracts of Papers of the American Chemical Society. 247.
- 2014
  
  Synthesis and study of covalent inhibitors of Mycobacterium tuberculosis GlgE. Abstracts of Papers of the American Chemical Society. 247.
- 2014
  
  Synthesis of a Poly-hydroxypyrolidine-Based inhibitor of Mycobacterium tuberculosis GlgE. Journal of Organic Chemistry. 79:9444-9450.
- 2014
  
  Synthesis of alpha-L-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibodies. Bioorganic & Medicinal Chemistry. 22:5279-5289.
- 2012
  
  Design, Synthesis, and X-ray Analysis of a Glycoconjugate Bound to Mycobacterium tuberculosis Antigen 85C. Bioconjugate Chemistry. 23:2403-2416.
- 2012
  
  Evaluation of arylsulfonyl protected aziridine-2-carboxylates to participate in nucleophilic glycosylations to afford glycosyl serine derivatives. Abstracts of Papers of the American Chemical Society. 244.
- 2012
  
  Improving vaccines with natural antibodies. Abstracts of Papers of the American Chemical Society. 244.
- 2012
  
  Synthesis of a-L-rhamnosylceramides. Abstracts of Papers of the American Chemical Society. 244.
- 2012
  
  Synthesis of beta-Glycosyl Amides from N-Glycosyl Dinitrobenzenesulfonamides. Journal of Carbohydrate Chemistry. 31:353-370.
- 2011
  
  Comparing the use of 2-methylenenapthyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl and 2,4,6-trimethoxybenzyl as N-H protecting groups for p-tolyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-beta-D-glucosides. Carbohydrate Research. 346:393-400.
- 2011
  
  Design, synthesis and characterization of thiophene-arabinoside conjugates as inhibitors of Mycobacterium tuberculosis antigen 85C. Abstracts of Papers of the American Chemical Society. 241.
- 2011
  
  Mixed-Phase Synthesis of Glycopeptides Using a N-Peptidyl-2, 4-dinitrobenzenesulfonamide-Thioacid Ligation Strategy. Organic Letters. 13:5298-5301.
- 2010
  
  Recent Advances Toward the Inhibition of mAG and LAM Synthesis in Mycobacterium tuberculosis. Medicinal Research Reviews. 30:290-326.
- 2009
  
  Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Molecular Biosystems. 5:945-956.
- 2009
  
  Synthesis of sialyl Lewis(a) (sLe(a), CA19-9) and construction of an immunogenic sLe(a) vaccine. Cancer Immunology Immunotherapy. 58:1397-1405.
- 2008
  
  CARB 45-Determination of the substrate specificity of antigen 85C-mediated acyl transfer on synthetic arabinofuranosides. Abstracts of Papers of the American Chemical Society. 236.
- 2008
  
  CARB 89-Glycopeptide synthesis by traceless decarboxylative condensation. Abstracts of Papers of the American Chemical Society. 235.
- 2008
  
  CARB 91-Synthesis of methyl 5-deoxy-5-S-thioalkyl-D-arabinofuranosides and evaluation of their antimycobacterial activity. Abstracts of Papers of the American Chemical Society. 235.
- 2008
  
  SOCED 5-Ohio REEL: Models for advancing research in the teaching laboratory. Abstracts of Papers of the American Chemical Society. 235.
- 2007
  
  CARB 40-Synthesis of glycosylamino acid containing dipeptides possessing a C-terminal alpha-ketoacid. Abstracts of Papers of the American Chemical Society. 233:545-545.
- 2005
  
  An efficient entry to new sugar modified ketolide antibiotics. Tetrahedron Letters. 46:1483-1487.
- 2005
  
  Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. Bioorganic & Medicinal Chemistry Letters. 15:2123-2128.
- 2004
  
  Dimeric aminoglycosides as antibiotics. Angewandte Chemie-International Edition. 43:1562-1566.
- 2004
  
  Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents. Bioorganic & Medicinal Chemistry Letters. 14:3733-3738.
- 2000
  
  RNA as a target for small molecules. Current Opinion in Chemical Biology. 4:678-686.
- 1998
  
  Total synthesis of bleomycin group antibiotics. Total syntheses of bleomycin demethyl A(2), bleomycin A(2), and decarbamoyl bleomycin demethyl A(2). Journal of the American Chemical Society. 120:11285-11296.
- 1992
  
  Characterization of [Pb(No3)(Ntam)2]No3, the 1st Metal-Complex of the Neutral Tetradentate Ligand Nitrilotriacetamide (Ntam). Journal of the Chemical Society-Chemical Communications. 367-368.
- 1992
  
  Facile Synthesis of Substituted Nitrilotriacetamides. Tetrahedron Letters. 33:7765-7768.
Chapter (Faculty180)
- 2020
  
  Strategies for developing carbohydrates as glycoside hydrolase inhibitors. Carbohydrate Chemistry. 207.
- 2018
  
  Advances in synthetic approaches towards glycoantigens. Carbohydrate-Based Vaccines: From Concept to Clinic. American Chemical Society. 175-195.
- 2017
  
  Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE. Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE. Wiley. 91-107.
Conference Poster (Faculty180)
Other Scholarly Work (Faculty180)
- 2020
  
  Anti-infective 2-aminothiophenes
- 2014
  
  Methods for forming peptides and peptide conjugates and peptides and peptide conjugates compositions formed thereby
Presentation (Faculty180)
Proceedings (Faculty180)

full name

Steve J Sucheck

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Cumulative publications in Scholars@UToledo

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