Goicoechea, Silvia M

Silvia M Goicoechea
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Positions

Assistant Research Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

Silvia.Goicoechea@utoledo.edu

https://www.utoledo.edu/nsm/bio/contact/silvia-mabel-goicoechea.html

selected publications

Article (Faculty180)
- 2022
  
  Quantification of ruffle area and dynamics in live or fixed lung adenocarcinoma cells. STAR protocols. 3:101437.
- 2021
  
  FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma. Cell reports. 37:109905.
- 2019
  
  SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility. The Journal of cell biology. 218:2699-2725.
- 2019
  
  The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly. Scientific reports. 9:5163.
- 2017
  
  A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells. Journal of cell science. 130:1064-1077.
- 2017
  
  Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio. Molecular biology of the cell. 28:1768-1781.
- 2017
  
  mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions. Biochemical and biophysical research communications. 484:255-261.
- 2016
  
  The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts. Scientific reports. 6:28805.
- 2015
  
  Palladin expression is a conserved characteristic of the desmoplastic tumor microenvironment and contributes to altered gene expression. Cytoskeleton (Hoboken, N.J.). 72:402-11.
- 2014
  
  I'm coming to GEF you: Regulation of RhoGEFs during cell migration. Cell adhesion & migration. 8:535-49.
- 2014
  
  Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene. 33:1265-73.
- 2013
  
  Structure and function of palladin's actin binding domain. Journal of molecular biology. 425:3325-37.
- 2010
  
  Isoform-specific upregulation of palladin in human and murine pancreas tumors. PloS one. 5:e10347.
- 2010
  
  The actin associated protein palladin is important for the early smooth muscle cell differentiation. PloS one. 5:e12823.
- 2009
  
  Characterization of cortactin as an in vivo protein kinase D substrate: interdependence of sites and potentiation by Src. Cellular signalling. 21:253-63.
- 2009
  
  Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease. Cell motility and the cytoskeleton. 66:618-34.
- 2009
  
  Palladin contributes to invasive motility in human breast cancer cells. Oncogene. 28:587-98.
- 2009
  
  Roles of the small GTPases RhoA and Rac1 in cell behavior. F1000 biology reports. 1:4.
- 2008
  
  The role of palladin in actin organization and cell motility. European journal of cell biology. 87:517-25.
- 2006
  
  Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. Journal of cell science. 119:3316-24.
- 2003
  
  Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly. The Journal of cell biology. 161:1179-89.
- 2002
  
  Nck-2 interacts with focal adhesion kinase and modulates cell motility. The international journal of biochemistry & cell biology. 34:791-805.
- 2002
  
  The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. The Journal of biological chemistry. 277:37219-28.
- 2000
  
  Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin. The Journal of biological chemistry. 275:36358-68.
- 1999
  
  The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Molecular and cellular biology. 19:2425-34.
- 1998
  
  Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. The Journal of biological chemistry. 273:528-36.
- 1997
  
  Influence of protein nutrition on calpain activity of mouse kidney: modulation by calpastatin. Molecular and cellular biochemistry. 166:95-9.
- 1994
  
  Effect of dietary level of protein on the activity of mouse liver calpain. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 26:175-80.
Article (Web of Science)
- 2021
  
  FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma. CELL REPORTS. 37.
  Full Text via DOI: 10.1016/j.celrep.2021.109905 PMID: 34731623
- 2019
  
  SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility. JOURNAL OF CELL BIOLOGY. 218:2699-2725.
  Full Text via DOI: 10.1083/jcb.201811114 PMID: 31248911
- 2019
  
  The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-41558-7 PMID: 30914742
- 2017
  
  Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio. MOLECULAR BIOLOGY OF THE CELL. 28:1768-1781.
  Full Text via DOI: 10.1091/mbc.E16-06-0412
- 2017
  
  A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells. JOURNAL OF CELL SCIENCE. 130:1064-1077.
  Full Text via DOI: 10.1242/jcs.195552
- 2017
  
  mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 484:255-261.
  Full Text via DOI: 10.1016/j.bbrc.2017.01.087
- 2017
  
  Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio. MOLECULAR BIOLOGY OF THE CELL. 28:1768-1781.
  Full Text via DOI: 10.1091/mbc.e16-06-0412
- 2016
  
  The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts. SCIENTIFIC REPORTS. 6.
  Full Text via DOI: 10.1038/srep28805
- 2015
  
  Palladin expression is a conserved characteristic of the desmoplastic tumor microenvironment and contributes to altered gene expression. CYTOSKELETON. 72:402-411.
  Full Text via DOI: 10.1002/cm.21239
- 2014
  
  Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. ONCOGENE. 33:1265-1273.
  Full Text via DOI: 10.1038/onc.2013.68
- 2013
  
  Structure and Function of Palladin's Actin Binding Domain. JOURNAL OF MOLECULAR BIOLOGY. 425:3325-3337.
  Full Text via DOI: 10.1016/j.jmb.2013.06.016
- 2010
  
  Isoform-Specific Upregulation of Palladin in Human and Murine Pancreas Tumors. PLOS ONE. 5:e10347.
  Full Text via DOI: 10.1371/journal.pone.0010347
- 2010
  
  The Actin Associated Protein Palladin Is Important for the Early Smooth Muscle Cell Differentiation. PLOS ONE. 5:e12823.
  Full Text via DOI: 10.1371/journal.pone.0012823
- 2009
  
  Characterization of cortactin as an in vivo protein kinase D substrate: Interdependence of sites and potentiation by Src. CELLULAR SIGNALLING. 21:253-263.
  Full Text via DOI: 10.1016/j.cellsig.2008.10.015
- 2009
  
  Palladin contributes to invasive motility in human breast cancer cells. ONCOGENE. 28:587-598.
  Full Text via DOI: 10.1038/onc.2008.408
- 2008
  
  The role of palladin in actin organization and cell motility. European Journal of Cell Biology. 87:517-525.
  Full Text via DOI: 10.1016/j.ejcb.2008.01.010
- 2006
  
  Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. JOURNAL OF CELL SCIENCE. 119:3316-3324.
  Full Text via DOI: 10.1242/jcs.03076
- 2003
  
  Low density lipoprotein receptor–related protein is a calreticulin coreceptor that signals focal adhesion disassembly. JOURNAL OF CELL BIOLOGY. 161:1179-1189.
  Full Text via DOI: 10.1083/jcb.200302069
- 2002
  
  Nck-2 interacts with focal adhesion kinase and modulates cell motility. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 34:791-805.
  Full Text via DOI: 10.1016/s1357-2725(02)00002-x
- 2002
  
  The Anti-adhesive Activity of Thrombospondin Is Mediated by the N-terminal Domain of Cell Surface Calreticulin. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:37219-37228.
  Full Text via DOI: 10.1074/jbc.m202200200
- 2000
  
  Thrombospondin Mediates Focal Adhesion Disassembly through Interactions with Cell Surface Calreticulin. JOURNAL OF BIOLOGICAL CHEMISTRY. 275:36358-36368.
  Full Text via DOI: 10.1074/jbc.m005951200
- 1998
  
  Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity. JOURNAL OF BIOLOGICAL CHEMISTRY. 273:528-536.
  Full Text via DOI: 10.1074/jbc.273.1.528
- 1996
  
  Estimation of ubiquitin and ubiquitin mRNA content in dark senescing wheat leaves. BIOLOGIA PLANTARUM. 38.
  Full Text via DOI: 10.1007/bf02896657
- 1994
  
  Effect of Dietary Level of Protein on the Activity of Mouse Liver Calpain. Hormone and Metabolic Research. 26:175-180.
  Full Text via DOI: 10.1055/s-2007-1000806
Chapter (Faculty180)
- 2002
  
  Cell surface calreticulin-thrombospondin de-adhesive activity in Calreticulin in Health and Disease.. Calreticulin: Second Edition.. Landes Bioscience. 193-204.
Conference Poster (Faculty180)
Meeting Abstract (Web of Science)
- 2016
  
  A RhoG-mediated signaling pathway that modulates invadopodia formation in breast cancer cells.. MOLECULAR BIOLOGY OF THE CELL.
- 2016
  
  Regulation of circular dorsal ruffles, macropinocytosis and cell migration by RhoG and its exchange factor Trio.. MOLECULAR BIOLOGY OF THE CELL.
- 2016
  
  The small GTPase RhoG modulates focal adhesion turnover.. MOLECULAR BIOLOGY OF THE CELL.
- 2014
  
  RhoG Negatively Regulates Invadopodia Formation.. MOLECULAR BIOLOGY OF THE CELL.
- 2014
  
  The Actin Crosslinking Protein Palladin Modulates Force Generation and Mechanical Sensing of Tumor Associated Fibroblasts. BIOPHYSICAL JOURNAL. 786a.
  Full Text via DOI: 10.1016/j.bpj.2013.11.4307
- 2013
  
  The actin-binding protein palladin localizes to the nucleus of pancreatic tumor-associated fibroblasts and regulates gene expression. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.FBCR13-B46
- 2013
  
  The Actin-Binding Protein Palladin Regulates both Gene Expression and the Metastasis-Promoting Behavior of Pancreatic Tumor-Associated Fibroblasts. MOLECULAR BIOLOGY OF THE CELL.
- 2013
  
  Abstract B46: The actin-binding protein palladin localizes to the nucleus of pancreatic tumor-associated fibroblasts and regulates gene expression
  Full Text via DOI: 10.1158/1538-7445.fbcr13-b46
- 2012
  
  A novel PDGF-mediated RhoG pathway in vascular smooth muscle cells.. MOLECULAR BIOLOGY OF THE CELL.
- 2012
  
  Palladin Cycles Between the Stress Fibers and the Nucleus to Regulate Transcription During Myofibroblast Differentiation. MOLECULAR BIOLOGY OF THE CELL.
- 2012
  
  Palladin expression modulates RhoG activation, migration and invasion of breast cancer cells.. MOLECULAR BIOLOGY OF THE CELL.
Presentation (Faculty180)
- 2015
  
  The regulation of RhoG in breast cancer metastasis
Review Article (Web of Science)
- 2014
  
  I'm coming to GEF you Regulation of RhoGEFs during cell migration. CELL ADHESION & MIGRATION. 535-549.
  Full Text via DOI: 10.4161/cam.28721
- 2009
  
  Cytoplasmic Ig-domain proteins: Cytoskeletal regulators with a role in human disease. Cell Motility and the Cytoskeleton. 618-634.
  Full Text via DOI: 10.1002/cm.20385

full name

Silvia M Goicoechea

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Cumulative publications in Scholars@UToledo

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