Liu, Shi-He

Shi-He Liu
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Positions

Biochemistry and Cancer Biology , College of Medicine and Life Sciences

Contact Info

Shi-He.Liu@UToledo.edu

selected publications

Article (Faculty180)
- 2018
  
  A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer. Cancer Lett. 418:75-83.
- 2017
  
  Cancer microarray data weighted gene co-expression network analysis identifies a gene module and hub genes shared across nine types of solid cancer. CellR4. 5.
- 2017
  
  Pancreatic cancer actionable genes in precision medicine and personalized surgery. Surgeon. 15:24-29.
- 2016
  
  Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma. Curr Mol Med. 16:83-90.
- 2016
  
  PDX1 associated therapy in translational medicine. Ann Transl Med. 4:214.
- 2015
  
  Liposomal insulin promoter-thymidine kinase gene therapy followed by ganciclovir effectively ablates human pancreatic cancer in mice. Cancer Lett. 359:206-10.
- 2014
  
  Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival. Cancer Research. 74:5301.
- 2014
  
  Cell surface lactate receptor GPR81 is crucial for cancer cell survival. Cancer Res. 74:5301-10.
- 2014
  
  Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin. Front Physiol. 5:226.
- 2014
  
  Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform. Cancer Gene Therapy. 21:48.
- 2013
  
  A Novel PDX-1-Specific, Synthetic Promoter Driving Systemic Suicide Gene Therapy Suppresses Pancreas Cancer (PC) Tumor Volume in Mice. Journal of Surgical Research. 179:193.
- 2013
  
  Assessment of intravenous pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) in yucatan swine. Cancer Gene Ther. 20:683-9.
- 2013
  
  Notch1 activation up-regulates pancreatic and duodenal homeobox-1. Genes (Basel). 4:358-74.
- 2013
  
  p38 MAP kinase interacts with and stabilizes pancreatic and duodenal homeobox-1. Curr Mol Med. 13:377-86.
- 2012
  
  509. Deletion of Proline 45 (PDX-1 ΔP45) Enhances Oncogenic Properties of PDX-1. Molecular Therapy. 20:S197.
- 2012
  
  509. Deletion of Proline 45 (PDX-1 ΔP45) Enhances Oncogenic Properties of PDX-1. Molecular Therapy. 20:S197.
- 2012
  
  Genomic sequencing of key genes in mouse pancreatic cancer cells. Current molecular medicine. 12:331-341.
- 2012
  
  Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5. Mol Endocrinol. 26:1225-34.
- 2012
  
  PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform. PLoS One. 7:e40452.
- 2011
  
  Defining the cancer master switch. World J Surg. 35:1738-45.
- 2011
  
  In vivo Safety and Antitumor Efficacy of Bifunctional Small Hairpin RNAs Specific for the Human Stathmin 1 Oncoprotein. DNA and Cell Biology. 30:715-726.
- 2011
  
  Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice. Surgery. 149:484-95.
- 2011
  
  PDX-1: demonstration of oncogenic properties in pancreatic cancer. Cancer. 117:723-33.
- 2011
  
  Personalized cancer approach: using RNA interference technology. World J Surg. 35:1700-14.
- 2011
  
  Phosphorylation-Dependent Stabilization Of Pancreatic And Duodenal Homeobox-1 (PDX-1). Journal of Surgical Research. 165:225.
- 2011
  
  SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes. Surgery. 150:1136-42.
- 2011
  
  Serum response factor expression is enriched in pancreatic beta cells and regulates insulin gene expression. FASEB J. 25:2592-603.
- 2011
  
  Somatostatin Receptor 1 and 5 Double Knockout Mice Mimic Neurochemical Changes of Huntington's Disease Transgenic Mice. PLOS ONE. 6:e24467.
- 2011
  
  The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function. World J Surg. 35:1715-24.
- 2010
  
  SSTR5 Down-Regulates PDX-1 via Inhibition of P38 MAP Kinase. Journal of Surgical Research. 158:332-333.
- 2009
  
  Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas. World J Surg. 33:630-7.
- 2008
  
  PDX-1 expression is associated with islet proliferation in vitro and in vivo. J Surg Res. 144:8-16.
- 2008
  
  Transcription factor PDX-1 in human colorectal adenocarcinoma: a potential tumor marker?. World J Gastroenterol. 14:5823-6.
- 2007
  
  Effective ablation of pancreatic cancer cells in SCID mice using systemic adenoviral RIP-TK/GCV gene therapy. J Surg Res. 141:45-52.
- 2007
  
  Enhanced Cytotoxicity of RIPTK Gene Therapy of Pancreatic Cancer via PDX-1 Co-Delivery. Journal of Surgical Research. 137:1-9.
- 2007
  
  Proliferation, hyperplasia, neogenesis, and neoplasia in the islets of Langerhans. Pancreas. 35:199-206.
- 2007
  
  [Chromosomal structural changes in patients with myelodysplastic syndrome]. Zhonghua Yi Xue Za Zhi. 87:2693-7.
- 2007
  
  [Clinical and laboratory investigation of hematological malignancy patients carrying 3q21q26 rearrangement]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 24:696-8.
- 2006
  
  Cytotoxic gene therapy for human breast cancer in vitro. J Surg Res. 136:154-60.
- 2006
  
  Enhanced cytotoxicity of RIPTK gene therapy via PDX-1 co-delivery. Journal of Surgical Research. 130:195-196.
- 2006
  
  Specific Targeting of Pancreatic Islet Cells In Vivo by Insulin-Promoter-Driven Adenoviral Conjugated Reporter Genes. World Journal of Surgery. 30:1543-1552.
- 2006
  
  [An analysis of cytogenetic characteristics and prognosis of 189 t (8; 21) acute myeloid leukemia patients]. Zhonghua Nei Ke Za Zhi. 45:918-21.
- 2006
  
  [Application of dual-color fluorescence in situ hybridization in acute myeloid leukemia with t (8; 21)]. Zhonghua Xue Ye Xue Za Zhi. 27:32-5.
- 2006
  
  [Clinical and laboratory study of a complex translocation t (6; 21; 8) (p22; q22; q22) in two patients with acute myeloid leukemia]. Zhonghua Xue Ye Xue Za Zhi. 27:314-7.
- 2006
  
  [Combination of interphase- and metaphase-fluorescence in situ hybridization to identify 11q23/MLL abnormalities in acute leukemia patients]. Zhonghua Xue Ye Xue Za Zhi. 27:682-6.
- 2005
  
  Analysis of 12p abnormalities of chromsome in 12 cases of myeloid malignanacies. Chin J Med Genet. 22:229-230.
- 2005
  
  Intravenous Delivery of Liposome-mediated Nonviral DNA Is Less Toxic than Intraperitoneal Delivery in Mice. World Journal of Surgery. 29:339-343.
- 2005
  
  Tetraploidy or near-tetraploidy clones with double 8;21 translocation: a non-random additional anomaly of acute myeloid leukemia with t(8;21)(q22;q22). Haematologica. 90:413.
- 2005
  
  The effect of global SSTR5 gene ablation on the endocrine pancreas and glucose regulation in aging mice. J Surg Res. 129:64-72.
- 2005
  
  The utilities of sequential R-banding and fluorescence in situ hybridization for the diagnosis of leukemia. Chin J Lab Med. 28:251-253.
- 2005
  
  WHO classification of 261 patients with acue myeloid leukemia. J Leukemia Lymphoma. 14:129-132.
- 2005
  
  [Conventional cytogenetics and fluorescence in situ hybridization as methods for detecting MLL gene rearrangements in leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13:798-803.
- 2005
  
  [Effectiveness analysis of HA based triple-drug regimen as induction chemotherapy in the treatment of acute myeloid leukemia and its relationship with karyotype]. Zhonghua Xue Ye Xue Za Zhi. 26:705-9.
- 2004
  
  AML1/RUNX1 fusion gene and t(5;21)(q13;q22) in a case of chronic myelomonocytic leukemia with progressive thrombocytopenia and monocytosis. Cancer Genet Cytogenet. 152:172-4.
- 2004
  
  Chronic myelomonocytic leukemia with t(5;21)(q13:q22): a case report and literature review. Chin J Hematol. 25:289.
- 2004
  
  Clinical and cytogenetic analysis of hematological malignancies with 3Q21 abnormalities. Tianjin Med J. 32:692-694.
- 2004
  
  Clinical and laboratory study of a case of hematidrosis. Chin J Hematol. 25:147-150.
- 2004
  
  IGH gene involvement in two cases of acute lymphoblastic leukemia with t(14;14) (q11;q32) identified by sequential R-banding and fluorescence in situ hybridization. Cancer Genet Cytogenet. 152:141-145.
- 2004
  
  Studying of the association of cellular drug resistnace in vitro with p170 expression and specific cytogenetic aberrations in patients with acute myeloid leukemia. J Leukemia Lymphoma. 13:323-325w.
- 2004
  
  The molecular cytogenetic study of acute myeloid leukemia with inv(16). Chin J Hematology. 25:367-369.
- 2004
  
  [Analysis and identification of variant Ph chromosome translocation in patients with chronic myelogenous leukemia by conventional cytogenetics and fluorescence in situ hybridization]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 12:298-303.
- 2004
  
  [Analysis of the factors associated with prognosis in patients with Ph chromosome positive adult acute lymphoblastic leukemia]. Zhonghua Xue Ye Xue Za Zhi. 25:417-20.
- 2004
  
  [Clinical and cytogenetic features of 29 cases of myelodysplastic syndrome associated with del(20q)]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21:171-2.
- 2004
  
  [Karyotypic and IPSS grouping of primary myelodysplastic syndromes patients: a comparison between FAB- and WHO-classification]. Zhonghua Xue Ye Xue Za Zhi. 25:482-5.
- 2004
  
  [Study of the childhood acute lymphoblastic leukemia with t(12;21)]. Zhonghua Xue Ye Xue Za Zhi. 25:17-21.
- 2004
  
  [The application of fluorescence in situ hybridization to diagnosis of acute promyelocytic leukemia]. Zhonghua Xue Ye Xue Za Zhi. 25:346-50.
- 2003
  
  A case of a patient with chronic myeloid leukemia in crisis of acute hybrid leukemia. Chin J Hematol. 24:665.
- 2003
  
  A comparative analysis of clinical and prognostic features between patients with Ph chromosome positive adult and childhood acute lymphoblastic leukemia. J Leukemia Lymphoma. 12:326-329.
- 2003
  
  Isochromosome 17q in patients with myelodysplastic syndromes: six new cases. Haematologica. 88:714.
- 2003
  
  Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia. Leukemia Research. 27:367-369.
- 2003
  
  Shwachman-Diamond syndrome: 1 case report and literatue review. J Leukemia Lymphoma. 12:377-380.
- 2003
  
  [Dendritic cells (DC) induced from acute myeloid leukemia (AML) cells with cytokine cocktails]. Zhonghua Xue Ye Xue Za Zhi. 24:365-8.
- 2003
  
  [Molecular cytogenetic analysis of -7/7q- abnormalities in patients with myeloid malignancies]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 20:471-6.
- 2002
  
  Interphase fluorescence in situ hybridization (FISH) for assessing response to therapy in chronic myeloid leukemia patients after IFN treatment. chine Journal of Practical Internal Medicine. 22:150-152.
- 2002
  
  [Comparison of detection of trisomy 8 with fluorescence in situ hybridization and conventional karyotype analysis in myelodysplastic syndrome]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 10:115-8.
- 2001
  
  A new complex variant t(4;15;17) in acute promyelocytic leukemia: fluorescence in situ hybridization confirmation and literature review. Cancer Genetics and Cytogenetics. 130:33-37.
- 2001
  
  Biological characteristics and projnostic significance of trisomy 21 in patients with myeloid malignant disease. Chin J Med Genet. 18:322-323.
- 2001
  
  [Clinical and cytogenetic analysis of patients with lymphoid malignancies carrying 14q32 abnormality]. Zhonghua Xue Ye Xue Za Zhi. 22:569-72.
- 2001
  
  [Dynamic monitoring of Ph positive cells during early post-transplant period in chronic granulocytic leukemia by interphase FISH]. Zhonghua Xue Ye Xue Za Zhi. 22:68-71.
- 2000
  
  Change of chromosomal karyotype in acute myelogenous leukemia during whole course of disease. Chin J Hematol. 21:387-388.
- 2000
  
  [Establishment and biological characteristics of a novel erythroleukemia cell line (HIE1)]. Zhonghua Xue Ye Xue Za Zhi. 21:6-9.
- 1997
  
  [Study on T lymphocyte recognition of tumor antigens on autologous CML cells]. Zhonghua Xue Ye Xue Za Zhi. 18:638-41.
- PDX-1 Acts as a Potential Molecular Target for Treatment of Human Pancreatic Cancer. Pancreas. 37:210-220.
Article (Web of Science)
- 2020
  
  Transcriptome sequencing analysis reveals unique and shared antitumor effects of three statins in pancreatic cancer. ONCOLOGY REPORTS. 44:2569-2580.
  Full Text via DOI: 10.3892/or.2020.7810 PMID: 33125137
- 2020
  
  Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21.
  Full Text via DOI: 10.3390/ijms21228679 PMID: 33213062
- 2020
  
  Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. CANCER LETTERS. 491:97-107.
  Full Text via DOI: 10.1016/j.canlet.2020.08.002 PMID: 32829010
- 2019
  
  BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. CANCER LETTERS. 457:10-19.
  Full Text via DOI: 10.1016/j.canlet.2019.04.036 PMID: 31059751
- 2018
  
  Analysis of the role of GSK3 in the mitotic checkpoint. SCIENTIFIC REPORTS. 8.
  Full Text via DOI: 10.1038/s41598-018-32435-w
- 2018
  
  A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer. CANCER LETTERS. 418:75-83.
  Full Text via DOI: 10.1016/j.canlet.2018.01.007
- 2013
  
  Notch1 Activation Up-Regulates Pancreatic and Duodenal Homeobox-1. GENES. 4:358-374.
  Full Text via DOI: 10.3390/genes4030358
- 2012
  
  Negative Regulation of Pancreatic and Duodenal Homeobox-1 by Somatostatin Receptor Subtype 5. MOLECULAR ENDOCRINOLOGY. 26:1225-1234.
  Full Text via DOI: 10.1210/me.2012-1095
- 2012
  
  PDX-1 Is a Therapeutic Target for Pancreatic Cancer, Insulinoma and Islet Neoplasia Using a Novel RNA Interference Platform. PLOS ONE. 7:e40452.
  Full Text via DOI: 10.1371/journal.pone.0040452
- 2011
  
  Defining the Cancer Master Switch. WORLD JOURNAL OF SURGERY. 35:1738-1745.
  Full Text via DOI: 10.1007/s00268-010-0941-2
- 2011
  
  Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice. SURGERY. 149:484-495.
  Full Text via DOI: 10.1016/j.surg.2010.11.014
- 2011
  
  PDX-1. Cancer. 117:723-733.
  Full Text via DOI: 10.1002/cncr.25629
- 2011
  
  Personalized Cancer Approach: Using RNA Interference Technology. WORLD JOURNAL OF SURGERY. 35:1700-1714.
  Full Text via DOI: 10.1007/s00268-011-1100-0
- 2011
  
  SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes. SURGERY. 150:1136-1142.
  Full Text via DOI: 10.1016/j.surg.2011.09.044
- 2011
  
  Serum response factor expression is enriched in pancreatic β cells and regulates insulin gene expression. FASEB JOURNAL. 25:2592-2603.
  Full Text via DOI: 10.1096/fj.10-173757
- 2011
  
  Somatostatin Receptor 1 and 5 Double Knockout Mice Mimic Neurochemical Changes of Huntington's Disease Transgenic Mice. PLOS ONE. 6:e24467.
  Full Text via DOI: 10.1371/journal.pone.0024467
- 2011
  
  The Hypofunctional Effect of P335L Single Nucleotide Polymorphism on SSTR5 Function. WORLD JOURNAL OF SURGERY. 35:1715-1724.
  Full Text via DOI: 10.1007/s00268-010-0939-9
- 2009
  
  Microarray Analysis of Somatostatin Receptor 5-Regulated Gene Expression Profiles in Murine Pancreas. WORLD JOURNAL OF SURGERY. 33:630-637.
  Full Text via DOI: 10.1007/s00268-008-9893-1
- 2008
  
  PDX-1 Acts as a Potential Molecular Target for Treatment of Human Pancreatic Cancer. PANCREAS. 37:210-220.
  Full Text via DOI: 10.1097/mpa.0b013e31816a4a33
- 2008
  
  PDX-1 Expression Is Associated with Islet Proliferation In Vitro and In Vivo. JOURNAL OF SURGICAL RESEARCH. 144:8-16.
  Full Text via DOI: 10.1016/j.jss.2007.04.018
- 2008
  
  Transcription factor PDX-1 in human colorectal adenocarcinoma: A potential tumor marker?. WORLD JOURNAL OF GASTROENTEROLOGY. 14:5823.
  Full Text via DOI: 10.3748/wjg.14.5823
- 2007
  
  Effective Ablation of Pancreatic Cancer Cells in SCID Mice Using Systemic Adenoviral RIP-TK/GCV Gene Therapy. JOURNAL OF SURGICAL RESEARCH. 141:45-52.
  Full Text via DOI: 10.1016/j.jss.2007.02.041
- 2007
  
  Enhanced Cytotoxicity of RIPTK Gene Therapy of Pancreatic Cancer via PDX-1 Co-Delivery. JOURNAL OF SURGICAL RESEARCH. 137:1-9.
  Full Text via DOI: 10.1016/j.jss.2006.04.039
- 2006
  
  Cytotoxic Gene Therapy for Human Breast Cancer In Vitro. JOURNAL OF SURGICAL RESEARCH. 136:154-160.
  Full Text via DOI: 10.1016/j.jss.2006.05.021
- 2006
  
  Specific Targeting of Pancreatic Islet Cells In Vivo by Insulin-Promoter-Driven Adenoviral Conjugated Reporter Genes. WORLD JOURNAL OF SURGERY. 30:1543-1552.
  Full Text via DOI: 10.1007/s00268-005-0688-3
Presentation (Faculty180)
Review Article (Web of Science)
- 2020
  
  Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
  Full Text via DOI: 10.3390/ijms21228823 PMID: 33233470
- 2007
  
  Proliferation, Hyperplasia, Neogenesis, and Neoplasia in the Islets of Langerhans. PANCREAS. 199-206.
  Full Text via DOI: 10.1097/mpa.0b013e318074c6ed

full name

Shi-He Liu

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