Overview
overview
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Peer-reviewed Articles:
- Ren, G., Zheng, X., Bommarito, M., Sharma, V, Letson, J., Walia, Y., Furuta, S. Organotypic three-dimensional co-culture of mammary epithelia and fibroblasts in discontinuous extracellular matrix shows in vivo-like fibrotic response to depletion of basal nitric oxide. Journal of Tissue Engineering. 2020 (in revision).
- Zheng, X., Fernando, V., Walia, Y., Sharma, V., Letson, J. and Furuta, S. Correction of Arginine Metabolism with Sepiapterin Induces Immunostimulatory-Shift of Breast Cancer. Biochem Pharmacol 2020; 113887 [Epub ahead of print].
- Ren, G., Sharma, V., Letson, J., Walia, Y., Furuta, S. Reconstituting breast tissue with organotypic three-dimensional co-culture of epithelial and stromal cells in discontinuous extracellular matrices. Bio-protocol 2019; 9(19):e3392.
- Fernando, V., Zheng, X., Walia, Y., Sherma, V., Letson, J., Furuta, S. S-nitrosylation: An emerging paradigm of redox signaling. Antioxidants 2019;8(9):pii: E404 PMID: 31533268
- Ren, G., Zheng, X., Bommarito, M., Metzger, S., Letson, J., Walia, Y., Furuta, S. Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ. Sci. Rep. 2019; 9(1):6688 PMID:31040372.
- Furuta S. (SF also serves as a co-corresponding author with MJB), Ren, G., Mao, J.H., Bissell, M.J. Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs. eLife. 2018; 7: e26148. PMCID: PMC5862529.
- Ricca, B.L., Venugopalan, G., Furuta, S., Tanner, K., Orellana, W.A., Reber, C.D., Brownfield, D.G., Bissell, M.J., Fletcher, D.A. Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. eLife. 2018; 7: e26161. PMCID: PMC5862525.
- Furuta, S. Basal S-nitrosylation is the guardian of tissue homeostasis. Trends in Cancer 2017; 3:744-748. PMID: 29120749.
- Furuta S. Role of Nitric Oxide (NO) in the Homeostasis of the Normal Breast and Relevance of its Loss to Stiffening of the Extracellular Matrix and Breast Tumor Initiation. J Cancer Oncol. 2017 1(1): 000101.
- Furuta S. Normal Epithelial Cells have Defense Mechanisms against Cancer. Austin Biochem. 2016 1(1): 1005.
- Furuta S, Bissell MJ. Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets. Cold Spring Harb Symp Quant Biol. 2016; 81:207-217. PMID: 28416576.
- Becker-Weimann, S., Xiong, G., Furuta, S., Han, J., Kuhn, I., Akavia, U.D., Pe’er, D., Bissell, M.J., Xu, R. NF-kappaB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget 2013; 4(11):2010-2020. PMCID: PMC3875766.
- Lee, S-Y.*, Meier, R.*, Furuta, S.* (*first three contributed equally; SF serves as a co-corresponding author with MJB), Lenburg, M.E., Kenny, P.A., Xu, R., Bissell, M.J. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J. Clin. Invest. 2012; 122(9):3211-3220. PMCID: PMC3428077.
- Ordinario, E., Han, H.J., Furuta, S., Heiser, L., Jakkula, L., Rodier, F., Spellman, P., Campisi, J., Gray, J., Bissell, M.J., Kohwi, Y., Kohwi-Shigematsu, T. ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PLOS One 2012;7(12):e51786. PMCID: PMC3519734.
- Furuta, S., Jeng, Y.M., Zhou, L., Huang, L., Kuhn, I., Bissell, M.J., Lee, W.H. IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med. 2011; 3(78):78ra31.
- Furuta, S., Ghajar, C.M., Bissell, M.J. Caveolin-1: Would-be Achilles’ heel of tumor microenvironment? Cell Cycle 2011; 10:1794-1809.
- Jeng, Y.M., Cai, S., Li, A., Furuta, S., Chen, P.L., Lee, E.Y.H.P., Lee, W.H. Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. Oncogene 2007; 24(42):6160-6.
- Furuta, S., Wang, J., Shuanzeng, W., Jeng, Y.M., Jiang, X., Gu, B., Chen, P.L., Lee, E.Y.H.P., Lee, W.H. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated breast tumor growth contributed by prominent vasculature. Cancer Cell 2006; 10(11):13-24.
- Furuta, S., Jiang, X., Gu, B, Cheng, E., Chen, P.L., Lee, W.H. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A. 2005; 102(26):9176-81.
- Utomo, A.*, Jiang, X.*, Furuta, S.*, (*first three contributed equally) Yun, J., Levin, D.S., Wang,Y.C., Desai, K.V., Green, J.E., Chen, P.L., Lee, W.H. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. J Biol Chem. 2004; 279(42):43522-9.
- Furuta, S., Ortiz, F., Zhu, Sun X., Wu, HH., Mason, A., Momand, J. Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. Biochem. J. 2002; 365(Pt 3):639-48.
- Makmura, L., Hamann, M., Areopagita, A., Furuta, S., Munoz, A., Momand, J. Development of sensitive assay to detect reversibly oxidized protein cysteine sulfhydryl groups. Antioxid. Redox Signal 2001; 3(6):1105-18.
Book Chapters:
- Momand, J., Aspuria, P.J., Furuta, S. “MDM2 and MDMX-regulators of p53 activity”, a chapter in Protein Reviews Vol 2: The p53 Tumor Suppressor Pathway and Cancer 2005; pp155-186. Kluwer Academic/Plenum Publishers (New York, NY).
Publications
selected publications
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Article (Faculty180)
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2020
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2019Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ. Scientific reports. 9:6688.
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2019Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ. Scientific Reports PMID: 31040372. 9:6688.
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2019S-Nitrosylation: An Emerging Paradigm of Redox Signaling. Antioxidants (Basel, Switzerland). 8.
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2017Basal S-Nitrosylation Is the Guardian of Tissue Homeostasis. Trends in cancer. 3:744-748.
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2016Normal Epithelial Cells have Defense Mechanisms against Cance. Austin Biochem. 1:1005.
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2016Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets. Cold Spring Harbor symposia on quantitative biology. 81:207-217.
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2013NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget. 4:2010-20.
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2012ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PloS one. 7:e51786.
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2012FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. The Journal of clinical investigation. 122:3211-20.
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2011Caveolin-1: would-be Achilles' heel of tumor microenvironment?. Cell cycle (Georgetown, Tex.). 10:3431.
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2011IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Science translational medicine. 3:78ra31.
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2005Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 102:9176-81.
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2002Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. The Biochemical journal. 365:639-48.
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2001Development of a sensitive assay to detect reversibly oxidized protein cysteine sulfhydryl groups. Antioxidants & redox signaling. 3:1105-18.
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Article (Web of Science)
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2021Protein Ligands in the Secretome of CD36(+) Fibroblasts Induce Growth Suppression in a Subset of Breast Cancer Cell Lines. CANCERS. 13.Full Text via DOI: 10.3390/cancers13184521 PMID: 34572749
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2020Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. BIOCHEMICAL PHARMACOLOGY. 176.Full Text via DOI: 10.1016/j.bcp.2020.113887 PMID: 32112882
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2019Large expert-curated database for benchmarking document similarity detection in biomedical literature search. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.Full Text via DOI: 10.1093/database/baz085
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2019Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGF beta. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-43239-x PMID: 31040372
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2019Reconstituting Breast Tissue with Organotypic Three-dimensional Co-culture of Epithelial and Stromal Cells in Discontinuous Extracellular Matrices. BIO-PROTOCOL. 9.Full Text via DOI: 10.21769/bioprotoc.3392
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2018Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. ELIFE. 7.Full Text via DOI: 10.7554/elife.26161
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2013NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. ONCOTARGET. 4:2010-2020.Full Text via DOI: 10.18632/oncotarget.1451
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2012ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells. PLOS ONE. 7:e51786.Full Text via DOI: 10.1371/journal.pone.0051786
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2012FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. JOURNAL OF CLINICAL INVESTIGATION. 122:3211-3220.Full Text via DOI: 10.1172/jci60498
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2011IL-25 Causes Apoptosis of IL-25R-Expressing Breast Cancer Cells Without Toxicity to Nonmalignant Cells. SCIENCE TRANSLATIONAL MEDICINE. 3:78ra31-78ra31.Full Text via DOI: 10.1126/scitranslmed.3001374
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2007Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. ONCOGENE. 26:6160-6166.Full Text via DOI: 10.1038/sj.onc.1210451
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2006Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell. 10:13-24.Full Text via DOI: 10.1016/j.ccr.2006.05.022
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2005Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 102:9176-9181.Full Text via DOI: 10.1073/pnas.0503793102
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2004Identification of a Novel Putative Non-selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase (NPGPx) Essential for Alleviating Oxidative Stress Generated from Polyunsaturated Fatty Acids in Breast Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:43522-43529.Full Text via DOI: 10.1074/jbc.m407141200
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2002Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells. BIOCHEMICAL JOURNAL. 365:639-648.Full Text via DOI: 10.1042/bj20011251
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2001Development of a Sensitive Assay to Detect Reversibly Oxidized Protein Cysteine Sulfhydryl Groups. Antioxidants & Redox Signaling. 3:1105-1118.Full Text via DOI: 10.1089/152308601317203611
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Book (Faculty180)
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2005MDM2 and MDMX-regulators of p53 activity, a chapter in Protein Reviews Vol 2: The p53 Tumor Suppressor Pathway and Cancer . Kluwer Academic/Plenum Publishers .
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Editorial Material (Web of Science)
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2017Basal S-Nitrosylation Is the Guardian of Tissue Homeostasis. TRENDS IN CANCER. 744-748.Full Text via DOI: 10.1016/j.trecan.2017.09.003
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2011Caveolin-1: Would-be Achilles’ heel of tumor microenvironment?. CELL CYCLE. 3431-3431.Full Text via DOI: 10.4161/cc.10.20.17648
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Proceedings Paper (Web of Science)
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2016Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets. Cold Spring Harbor Symposia on Quantitative Biology. 207-217.Full Text via DOI: 10.1101/sqb.2016.81.030825
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Review Article (Web of Science)
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2021S-Nitrosylation in Tumor Microenvironment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms22094600 PMID: 33925645
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2019S-Nitrosylation: An Emerging Paradigm of Redox Signaling. ANTIOXIDANTS.Full Text via DOI: 10.3390/antiox8090404 PMID: 31533268
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Contact
full name
- Saori Furuta
visualizations
Cumulative publications in Scholars@UToledo