Sai Hanuman Sagar Boddu
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Assistant Professor
Associate Professor
Director of Industrial Pharmacy Graduate Program, University of Toledo
Overview
overview
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Dr. Boddu is an Associate Professor and the director of the Industrial Pharmacy Graduate Program at the University of Toledo, College of Pharmacy and Pharmaceutical Sciences. Dr. Boddu earned a Bachelor of Pharmacy (B. Pharm) from Bapatla College of Pharmacy and Master of Pharmacy (M. Pharm) in Pharmaceutics from the NDMVP Samaj’s College of Pharmacy, University of Pune, India. Later he joined as a research associate at Wockhardt Ltd., a leading generic pharmaceutical and biotechnology company. While employed there, he invented an aqueous solution dosage form for oral administration of risperidone. This dosage form is approved for treating schizophrenia in adults. His work and ideas in this area have been patented (WIPO Patent Application WO/2007/138462). Dr. Boddu received his Ph.D. in Pharmaceutical Sciences from the University of Missouri-Kansas City (UMKC) in December 2010. Dr. Boddu has designed and characterized various novel drug delivery systems for the treatment of posterior segment ocular diseases such as diabetic macular edema and retinoblastoma. He has published more than 50 research and review articles in various peer-reviewed journals. Dr. Boddu is a co-Editor of the book entitled "Excipient Applications in Formulation Design and Drug Delivery". He secured over $100,000 in research funding from various foundations and pharmaceutical companies. He received the prestigious UMKC Chancellor’s Doctoral Fellowship Award for the years 2008-2010. He was the recipient of UMKC Vice Chancellor for Student Affairs and Enrollment Management Honor in the fall of 2010. Dr. Boddu serves as a Steering Committee member of the AAPS Microdialysis Focus Group. Dr. Boddu’s current research interests are developing novel drug delivery systems for the treatment of anterior and posterior segment ocular diseases and various types of cancers. In addition, he works closely with clinicians to design novel drug delivery systems and technologies for translational research on treatment of chronic sinusitis and scleroderma.
Publications
selected publications
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Article (Faculty180)
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2017Physical compatibility of valproate sodium injection with dobutamine and dopamine. Am J Health Syst Pharm. 74:280-281.
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2016Dry Eye Disease: Present Challenges in the Management and Future Trends. Curr Pharm Des. 22:4470-90.
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2016Evaluation of the percutaneous absorption of chlorpromazine from PLO gels across porcine ear and human abdominal skin. Drug Dev Ind Pharm. 42:1258-66.
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2016Formulation and In Vitro Evaluation of Cyclosporine-A Inserts Prepared Using Hydroxypropyl Methylcellulose for Treating Dry Eye Disease. J Ocul Pharmacol Ther. 32:451-62.
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2016Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels. J Pharm Pharm Sci. 19:252-73.
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2015Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery. Int J Pharm. 479:207-11.
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2015Development and characterization of a ricinoleic acid poloxamer gel system for transdermal eyelid delivery. Drug Dev Ind Pharm. 41:605-12.
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2015Development and characterization of erythrosine nanoparticles with potential for treating sinusitis using photodynamic therapy. Photodiagnosis Photodyn Ther. 12:9-18.
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2015Development and evaluation of dexamethasone nanomicelles with potential for treating posterior uveitis after topical application. J Ocul Pharmacol Ther. 31:215-27.
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2015Masking the bitter taste of injectable lidocaine HCl formulation for dental procedures. AAPS PharmSciTech. 16:455-65.
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2014
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2014Compatibility of argatroban injection with select antiarrhythmic drugs. Am J Health Syst Pharm. 71:1831-2.
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2014Compatibility of conivaptan injection with select cardiovascular medications. Am J Health Syst Pharm. 71:1534-5.
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2014Drug delivery to the back of the eye following topical administration: an update on research and patenting activity. Recent Pat Drug Deliv Formul. 8:27-36.
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2014Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. Front Behav Neurosci. 8:366.
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2014Preclinical evaluation of a ricinoleic acid poloxamer gel system for transdermal eyelid delivery. Int J Pharm. 470:158-61.
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2014Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery. Int J Pharm Compd. 18:256-61.
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2014Recent patents on ophthalmic nanoformulations and therapeutic implications. Recent Pat Drug Deliv Formul. 8:193-201.
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2013Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm. 447:75-93.
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2013Physical compatibility of sodium citrate with alcohol and cefepime. Am J Health Syst Pharm. 70:932, 937.
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2012Recent overview of ocular patents. Recent Pat Drug Deliv Formul. 6:95-106.
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2011
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2011Ocular sustained release nanoparticles containing stereoisomeric dipeptide prodrugs of acyclovir. J Ocul Pharmacol Ther. 27:163-72.
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2010Development and validation of a sensitive bioanalytical method for the quantitative estimation of pantoprazole in human plasma samples by LC-MS/MS: application to bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 878:1499-505.
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2010In vitro evaluation of a targeted and sustained release system for retinoblastoma cells using Doxorubicin as a model drug. J Ocul Pharmacol Ther. 26:459-68.
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2010Novel nanoparticulate gel formulations of steroids for the treatment of macular edema. J Ocul Pharmacol Ther. 26:37-48.
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2010
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2010Vitreal pharmacokinetics of peptide-transporter-targeted prodrugs of ganciclovir in conscious animals. J Ocul Pharmacol Ther. 26:265-71.
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2009
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2009Recent perspectives in ocular drug delivery. Pharm Res. 26:1197-216.
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2009Vitreal pharmacokinetics of biotinylated ganciclovir: role of sodium-dependent multivitamin transporter expressed on retina. J Ocul Pharmacol Ther. 25:39-49.
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2008Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm. 359:7-14.
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2007Novel approaches to retinal drug delivery. Expert Opin Drug Deliv. 4:371-88.
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Article (Web of Science)
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2018FSE-Ag complex NS: preparation and evaluation of antibacterial activity. IET NANOBIOTECHNOLOGY. 12:836-840.Full Text via DOI: 10.1049/iet-nbt.2017.0284
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2018Elucidation of the orientation of selected drugs with 2-hydroxylpropyl-beta-cyclodextrin using 2D-NMR spectroscopy and molecular modeling. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 545:357-365.Full Text via DOI: 10.1016/j.ijpharm.2018.05.016
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2018Development and Evaluation of a Novel Microemulsion of Dexamethasone and Tobramycin for Topical Ocular Administration. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. 34:312-324.Full Text via DOI: 10.1089/jop.2017.0082
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2018CYTOTOXICITY OF INHALABLE DRY POWDERS IN A549 HUMAN LUNG CANCER CELL LINE. FARMACIA. 66:172-175.
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2017Comparison of electrospun and solvent cast polylactic acid (PLA)/polyvinyl alcohol) (PVA) inserts as potential ocular drug delivery vehicles. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS. 77:895-903.Full Text via DOI: 10.1016/j.msec.2017.03305
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2017Folate Decorated Nanomicelles Loaded with a Potent Curcumin Analogue for Targeting Retinoblastoma. PHARMACEUTICS. 9.Full Text via DOI: 10.3390/pharmaceutics9020015
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2017Tanshinone IIA Inhibits VEGF Secretion and HIF-1 alpha Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia. CURRENT EYE RESEARCH. 42:1667-1673.Full Text via DOI: 10.1080/02713683.2017.1355467
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2016Evaluation of the percutaneous absorption of chlorpromazine from PLO gels across porcine ear and human abdominal skin. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 42:1258-1266.Full Text via DOI: 10.3109/03639045.2015.1122610
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2016Formulation and In Vitro Evaluation of Cyclosporine-A Inserts Prepared Using Hydroxypropyl Methylcellulose for Treating Dry Eye Disease. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. 32:451-462.Full Text via DOI: 10.1089/jop.2016.0013
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2016Organogels in Drug Delivery: A Special Emphasis on Organogels. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 19:252-273.
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2015Development and Evaluation of Dexamethasone Nanomicelles with Potential for Treating Posterior Uveitis After Topical Application. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. 31:215-227.Full Text via DOI: 10.1089/jop.2014.0152
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2015Development and characterization of a ricinoleic acid poloxamer gel system for transdermal eyelid delivery. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 41:605-612.Full Text via DOI: 10.3109/03639045.2014.886696
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2015Masking the Bitter Taste of Injectable Lidocaine HCl Formulation for Dental Procedures. AAPS PHARMSCITECH. 16:455-465.Full Text via DOI: 10.1208/s12249-014-0239-z
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2015Development and characterization of erythrosine nanoparticles with potential for treating sinusitis using photodynamic therapy. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY. 12:9-18.Full Text via DOI: 10.1016/j.pdpdt.2015.01.005
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2015Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 479:207-211.Full Text via DOI: 10.1016/j.ijpharm.2014.12.051
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2014Characterization and Evaluation of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles Prepared via a Temperature-Modulated Solidification Technique. AAPS PHARMSCITECH. 15:1498-1508.Full Text via DOI: 10.1208/s12249-014-0168-x
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2014Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 8.Full Text via DOI: 10.3389/fnbeh.2014.00366
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2014Preclinical evaluation of a ricinoleic acid poloxamer gel system for transdermal eyelid delivery. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 470:158-161.Full Text via DOI: 10.1016/j.ijpharm.2014.04.057
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2013Development and Characterization of Nanostructured Mists with Potential for Actively Targeting Poorly Water-Soluble Compounds into the Lungs. PHARMACEUTICAL RESEARCH. 30:2625-2639.Full Text via DOI: 10.1007/s11095-013-1088-2
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2012Differential Expression of Folate Receptor-Alpha, Sodium-Dependent Multivitamin Transporter, and Amino Acid Transporter (B ((0, +))) in Human Retinoblastoma (Y-79) and Retinal Pigment Epithelial (ARPE-19) Cell Lines. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. 28:237-244.Full Text via DOI: 10.1089/jop.2011.0155
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2011Functional Characterization of Folate Transport Proteins in Staten's Seruminstitut Rabbit Corneal Epithelial Cell Line. CURRENT EYE RESEARCH. 36:404-416.Full Text via DOI: 10.3109/02713683.2011.566411
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2011Ocular Sustained Release Nanoparticles Containing Stereoisomeric Dipeptide Prodrugs of Acyclovir. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. 27:163-172.Full Text via DOI: 10.1089/jop.2010.0188
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Correction (Web of Science)
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2015Preclinical evaluation of a ricinoleic acid poloxamer gel system for transdermal eyelid delivery (vol 470, pg 158, 2014). INTERNATIONAL JOURNAL OF PHARMACEUTICS. 383-383.Full Text via DOI: 10.1016/j.ijpharm.2015.03.066
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Letter (Web of Science)
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2018Physical compatibility of milrinone with levofloxacin and ceftriaxone injection. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY. 1010-1012.Full Text via DOI: 10.2146/ajhp180195
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2018Physical compatibility of levetiracetam injection with heparin, dobutamine, and dopamine. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY. 510-512.Full Text via DOI: 10.2146/ajhp180069
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2017Physical compatibility of valproate sodium injection with dobutamine and dopamine. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY. 280-281.Full Text via DOI: 10.2146/ajhp160924
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2014Compatibility of argatroban injection with select antiarrhythmic drugs. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY. 1831-1832.Full Text via DOI: 10.2146/ajhp140258
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2013Physical compatibility of sodium citrate with alcohol and cefepime. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY. 932-+.Full Text via DOI: 10.2146/ajhp120499
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Meeting Abstract (Web of Science)
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2018Expression of Folate Receptor (FR-alpha) and Proton Coupled Folate Transporter (PCFT) on RPCEC and HCEC Cell Line. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.
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Review Article (Web of Science)
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2018Ocular Drug Delivery Barriers-Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases. PHARMACEUTICS.Full Text via DOI: 10.3390/pharmaceutics10010028
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2016Dry Eye Disease: Present Challenges in the Management and Future Trends. CURRENT PHARMACEUTICAL DESIGN. 4470-4490.Full Text via DOI: 10.2174/1381612822666160614012634
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2013Approaches for enhancing oral bioavailability of peptides and proteins. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 75-93.Full Text via DOI: 10.1016/j.ijpharm.2013.02.030
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Contact
full name
- Sai Hanuman Sagar Boddu