Wooten, Ronald M

Ronald M Wooten
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Positions

C0-Director, BSL3 Laboratory
Co-Director, Thread 1 Medical Curriculum
Chairman, Institutional Biosafety Committee, Medical Microbiology and Immunology , College of Medicine and Life Sciences

Contact Info

R.Mark.Wooten@utoledo.edu

selected publications

Article (Web of Science)
- 2021
  
  Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.
  Full Text via DOI: 10.3390/ijms22189939 PMID: 34576099
- 2017
  
  Borrelia burgdorferi CheY2 Is Dispensable for Chemotaxis or Motility but Crucial for the Infectious Life Cycle of the Spirochete. INFECTION AND IMMUNITY. 85.
  Full Text via DOI: 10.1128/IAI.00264-16
- 2017
  
  Borrelia burgdorferi CheY2 Is Dispensable for Chemotaxis or Motility but Crucial for the Infectious Life Cycle of the Spirochete. INFECTION AND IMMUNITY. 85.
  Full Text via DOI: 10.1128/iai.00264-16
- 2016
  
  The Borrelia burgdorferi CheY3 response regulator is essential for chemotaxis and completion of its natural infection cycle. CELLULAR MICROBIOLOGY. 18:1782-1799.
  Full Text via DOI: 10.1111/cmi.12617
- 2015
  
  Motor Rotation Is Essential for the Formation of the Periplasmic Flagellar Ribbon, Cellular Morphology, and Borrelia burgdorferi Persistence within Ixodes scapularis Tick and Murine Hosts. INFECTION AND IMMUNITY. 83:1765-1777.
  Full Text via DOI: 10.1128/IAI.03097-14
- 2015
  
  Motor Rotation Is Essential for the Formation of the Periplasmic Flagellar Ribbon, Cellular Morphology, and Borrelia burgdorferi Persistence within Ixodes scapularis Tick and Murine Hosts. INFECTION AND IMMUNITY. 83:1765-1777.
  Full Text via DOI: 10.1128/iai.03097-14
- 2014
  
  Delineating the Importance of Serum Opsonins and the Bacterial Capsule in Affecting the Uptake and Killing of Burkholderia pseudomallei by Murine Neutrophils and Macrophages. PLOS NEGLECTED TROPICAL DISEASES. 8.
  Full Text via DOI: 10.1371/journal.pntd.0002988
- 2013
  
  Borrelia burgdorferi Elicited-IL-10 Suppresses the Production of Inflammatory Mediators, Phagocytosis, and Expression of Co-Stimulatory Receptors by Murine Macrophages and/or Dendritic Cells. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0084980
- 2013
  
  Secretion of growth factors from macrophages when cultured with microparticles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 101:3170-3180.
  Full Text via DOI: 10.1002/jbm.a.34604
- 2012
  
  Capsule Influences the Deposition of Critical Complement C3 Levels Required for the Killing of Burkholderia pseudomallei via NADPH-Oxidase Induction by Human Neutrophils. PLOS ONE. 7.
  Full Text via DOI: 10.1371/journal.pone.0052276
- 2012
  
  Human platelets efficiently kill IgG-opsonized E. coli. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 65:78-83.
  Full Text via DOI: 10.1111/j.1574-695X.2012.00945.x
- 2012
  
  ELISA-Based Measurement of Antibody Responses and PCR-Based Detection Profiles Can Distinguish between Active Infection and Early Clearance of Borrelia burgdorferi. CLINICAL & DEVELOPMENTAL IMMUNOLOGY.
  Full Text via DOI: 10.1155/2012/138069
- 2012
  
  Human platelets efficiently kill IgG-opsonizedE. coli. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 65:78-83.
  Full Text via DOI: 10.1111/j.1574-695x.2012.00945.x
- 2010
  
  Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells. BMC MICROBIOLOGY. 10.
  Full Text via DOI: 10.1186/1471-2180-10-250
- 2009
  
  Roles for phagocytic cells and complement in controlling relapsing fever infection. JOURNAL OF LEUKOCYTE BIOLOGY. 86:727-736.
  Full Text via DOI: 10.1189/jlb.0309169
- 2008
  
  Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages. INFECTION AND IMMUNITY. 76:1153-1162.
  Full Text via DOI: 10.1128/IAI.01404-07
- 2008
  
  Viable Borrelia burgdorferi Enhances Interleukin-10 Production and Suppresses Activation of Murine Macrophages. INFECTION AND IMMUNITY. 76:1153-1162.
  Full Text via DOI: 10.1128/iai.01404-07
- 2007
  
  Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection. INFECTION AND IMMUNITY. 75:3131-3139.
  Full Text via DOI: 10.1128/IAI.01923-06
- 2007
  
  The Moraxella catarrhalis autotransporter McaP is a conserved surface protein that mediates adherence to human epithelial cells through its N-terminal passenger domain. INFECTION AND IMMUNITY. 75:314-324.
  Full Text via DOI: 10.1128/IAI.01330-06
- 2007
  
  Borrelia burgdorferi Binding of Host Complement Regulator Factor H Is Not Required for Efficient Mammalian Infection. INFECTION AND IMMUNITY. 75:3131-3139.
  Full Text via DOI: 10.1128/iai.01923-06
- 2007
  
  The Moraxella catarrhalis Autotransporter McaP Is a Conserved Surface Protein That Mediates Adherence to Human Epithelial Cells through Its N-Terminal Passenger Domain. INFECTION AND IMMUNITY. 75:314-324.
  Full Text via DOI: 10.1128/iai.01330-06
- 2006
  
  Gene Expression Profiling Reveals Unique Pathways Associated with Differential Severity of Lyme Arthritis. JOURNAL OF IMMUNOLOGY. 177:7930-7942.
  Full Text via DOI: 10.4049/jimmunol.177.11.7930
- 2006
  
  IL-10 Deficiency Promotes IncreasedBorrelia burgdorferiClearance Predominantly through Enhanced Innate Immune Responses. JOURNAL OF IMMUNOLOGY. 177:7076-7085.
  Full Text via DOI: 10.4049/jimmunol.177.10.7076
- 2006
  
  Identification of aFrancisella tularensisLVS outer membrane protein that confers adherence to A549 human lung cells. FEMS Microbiology Letters. 263:102-108.
  Full Text via DOI: 10.1111/j.1574-6968.2006.00413.x
- 2004
  
  Effects of vlsE Complementation on the Infectivity of Borrelia burgdorferi Lacking the Linear Plasmid lp28-1. INFECTION AND IMMUNITY. 72:6577-6585.
  Full Text via DOI: 10.1128/iai.72.11.6577-6585.2004
- 2003
  
  Effect of Complement Component C3 Deficiency on Experimental Lyme Borreliosis in Mice. INFECTION AND IMMUNITY. 71:4432-4440.
  Full Text via DOI: 10.1128/iai.71.8.4432-4440.2003
- 2003
  
  Tripalmitoyl- S -Glyceryl-Cysteine-Dependent OspA Vaccination of Toll-Like Receptor 2-Deficient Mice Results in Effective Protection from Borrelia burgdorferi Challenge. INFECTION AND IMMUNITY. 71:3894-3900.
  Full Text via DOI: 10.1128/iai.71.7.3894-3900.2003
- 2002
  
  Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense toBorrelia burgdorferi. JOURNAL OF IMMUNOLOGY. 168:348-355.
  Full Text via DOI: 10.4049/jimmunol.168.1.348
- 2001
  
  Resistance to Lyme disease in decorin-deficient mice. JOURNAL OF CLINICAL INVESTIGATION. 107:845-852.
  Full Text via DOI: 10.1172/jci11692
- 1999
  
  Dual Role of Interleukin-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host Defense. INFECTION AND IMMUNITY. 67:5142-5150.
  Full Text via DOI: 10.1128/iai.67.10.5142-5150.1999
- 1997
  
  Effects of oleic acid on murine CD4+ T cell death and anti-CD3 or superantigen induced proliferation at low temperature. Developmental & Comparative Immunology. 21:375-384.
  Full Text via DOI: 10.1016/s0145-305x(97)00015-3
- 1996
  
  Anergy or cell death induced by low physiological temperature in mitogen-stimulated human T lymphocytes. JOURNAL OF THERMAL BIOLOGY. 21:381-388.
  Full Text via DOI: 10.1016/s0306-4565(96)00026-5
- 1994
  
  A serum-free medium for human primary T lymphocyte culture. Journal of Immunological Methods. 175:115-121.
  Full Text via DOI: 10.1016/0022-1759(94)90337-9
- 1993
  
  The Effects of Temperature and Oleic Acid on Murine Memory and Virgin T Cell Activation: Interleukin-2 Secretion and Interleukin-2 Receptor Expression. CELLULAR IMMUNOLOGY. 152:35-48.
  Full Text via DOI: 10.1006/cimm.1993.1265
Conference Poster (Faculty180)
Meeting Abstract (Web of Science)
- 2015
  
  Loss of chemotaxis gene Delta cheY3 in Borrelia burgdorferi leads to early immune clearance but does elicits a strong antibody response. JOURNAL OF IMMUNOLOGY.
- 2010
  
  Borrelia burgdorferi elicits dysregulated IL-10 production by macrophages via a TLR2-dependent, yet distinct, signaling pathway than those involved in pro-inflammatory responses. JOURNAL OF IMMUNOLOGY.
- 2010
  
  Intravital imaging of Borrelia burgdorferi and murine innate immune cells during early cutaneous infection. JOURNAL OF IMMUNOLOGY.
Presentation (Faculty180)
- 2013
  
  Real-time 3-D Microscopy of Borrelia burgdorferi Pathogenesis within Living Host Skin: Characterization of Spirochetal Dissemination Kinetics and Persistence
Review Article (Web of Science)
- 2021
  
  Interactions Between Pathogenic Burkholderia and the Complement System: A Review of Potential Immune Evasion Mechanisms. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.
  Full Text via DOI: 10.3389/fcimb.2021.701362 PMID: 34660335
- 2021
  
  Immune Response to Borrelia: Lessons from Lyme Disease Spirochetes. CURRENT ISSUES IN MOLECULAR BIOLOGY. 145-190.
  Full Text via DOI: 10.21775/cimb.042.145 PMID: 33289684
- 2015
  
  Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease. CURRENT OPINION IN MICROBIOLOGY. 106-113.
  Full Text via DOI: 10.1016/j.mib.2015.09.006
- 2001
  
  Host–pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes. CURRENT OPINION IN MICROBIOLOGY. 274-279.
  Full Text via DOI: 10.1016/s1369-5274(00)00202-2

full name

Ronald M Wooten

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