Erhardt, Paul W

Paul W Erhardt
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Positions

Distinguished University Professor Emeritus
Professor, University of Toledo

Contact Info

Paul.Erhardt@utoledo.edu

selected publications

Article (Faculty180)
- 2016
  
  Cytochrome P450 CYP93A1 as a defense marker in soybean. Biologia Plantarum. 60:724-730.
- 2001
  
  Mechanistic considerations pertaining to the solvolysis of paclitaxel analogs bearing ester groups at the C2' position. Tetrahedron letters. 42:7747-7750.
Article (Web of Science)
- 2021
  
  Synthesis and Evaluation of PPAR delta Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis. JOURNAL OF MEDICINAL CHEMISTRY. 64:6996-7032.
  Full Text via DOI: 10.1021/acs.jmedchem.1c00560 PMID: 33988379
- 2021
  
  Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report). PURE AND APPLIED CHEMISTRY. 93:273-403.
  Full Text via DOI: 10.1515/pac-2018-0208
- 2020
  
  Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. CANCER LETTERS. 491:97-107.
  Full Text via DOI: 10.1016/j.canlet.2020.08.002 PMID: 32829010
- 2020
  
  Investigating the Potential to Deliver and Maintain Plasma and Brain Levels of a Novel Practically Insoluble Methuosis Inducing Anticancer Agent 5-Methoxy MOMIPP Through an Injectable In Situ Forming Thermoresponsive Hydrogel Formulation. JOURNAL OF PHARMACEUTICAL SCIENCES. 109:2719-2728.
  Full Text via DOI: 10.1016/j.xphs.2020.05.014 PMID: 32473210
- 2020
  
  Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α. JOURNAL OF BIOLOGICAL CHEMISTRY. 295:9804-9822.
  Full Text via DOI: 10.1074/jbc.ra120.013700
- 2019
  
  6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability. CANCER CHEMOTHERAPY AND PHARMACOLOGY. 83:237-254.
  Full Text via DOI: 10.1007/s00280-018-3726-1
- 2019
  
  The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC CANCER. 19.
  Full Text via DOI: 10.1186/s12885-019-5288-y
- 2019
  
  BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. CANCER LETTERS. 457:10-19.
  Full Text via DOI: 10.1016/j.canlet.2019.04.036 PMID: 31059751
- 2018
  
  Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells. NUTRIENTS. 10.
  Full Text via DOI: 10.3390/nu10111644
- 2017
  
  Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIb alpha. NATURE COMMUNICATIONS. 8.
  Full Text via DOI: 10.1038/ncomms15559
- 2016
  
  Cytochrome P-450, CYP93A1, as defense marker in soybean. BIOLOGIA PLANTARUM. 60:724-730.
  Full Text via DOI: 10.1007/s10535-016-0629-z
- 2016
  
  Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: Effects on potency and mode of activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 122:79-91.
  Full Text via DOI: 10.1016/j.ejmech.2016.06.016
- 2015
  
  Total Synthesis of (+/-)-Glyceollin II and a Dihydro Derivative. JOURNAL OF NATURAL PRODUCTS. 78:2940-2947.
  Full Text via DOI: 10.1021/acs.jnatprod.5b00607
- 2015
  
  Synthesis and Biological Evaluation of Indolyl-Pyridinyl-Propenones Having Either Methuosis or Microtubule Disruption Activity. JOURNAL OF MEDICINAL CHEMISTRY. 58:2489-2512.
  Full Text via DOI: 10.1021/jm501997q
- 2014
  
  Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones. ACS MEDICINAL CHEMISTRY LETTERS. 5:73-77.
  Full Text via DOI: 10.1021/ml4003925
- 2013
  
  Synthesis of 6a-hydroxypterocarpans via intramolecular benzoin condensation. TETRAHEDRON LETTERS. 54:4121-4124.
  Full Text via DOI: 10.1016/j.tetlet.2013.05.121
- 2013
  
  Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 63:104-108.
  Full Text via DOI: 10.1016/j.ejmech.2013.02.012
- 2013
  
  Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013). PURE AND APPLIED CHEMISTRY. 85:1725-1758.
  Full Text via DOI: 10.1351/PAC-REC-12-11-23
- 2013
  
  Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013). PURE AND APPLIED CHEMISTRY. 85:1725-1758.
  Full Text via DOI: 10.1351/pac-rec-12-11-23
- 2012
  
  Glyceollins, Soy Isoflavone Phytoalexins, Improve Oral Glucose Disposal by Stimulating Glucose Uptake. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 60:6376-6382.
  Full Text via DOI: 10.1021/jf301057d
- 2012
  
  Early Stage Efficacy and Toxicology Screening for Antibiotics and Enzyme Inhibitors. JOURNAL OF BIOMOLECULAR SCREENING. 17:673-682.
  Full Text via DOI: 10.1177/1087057112438769
- 2012
  
  On the Interaction of Aliphatic Amines and Ammonium Ions with Carboxylic Acids in Solution and in Receptor Pockets. JOURNAL OF PHYSICAL CHEMISTRY B. 116:5425-5436.
  Full Text via DOI: 10.1021/jp300588q
- 2012
  
  Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase. BIOORGANIC & MEDICINAL CHEMISTRY. 20:2950-2956.
  Full Text via DOI: 10.1016/j.bmc.2012.03.013
- 2012
  
  Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death. JOURNAL OF MEDICINAL CHEMISTRY. 55:1940-1956.
  Full Text via DOI: 10.1021/jm201006x
- 2012
  
  Analogue-based drug discovery: Contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (Special Topic Article). PURE AND APPLIED CHEMISTRY. 84:1479-1542.
  Full Text via DOI: 10.1351/PAC-CON-12-02-13
- 2012
  
  HITTING A SOFT DRUG WITH A HARD NUCLEOPHILE: PREPARATION OF ESMOLOL'S METABOLITE BY TREATMENT WITH BIS(TRIBUTYLTIN) OXIDE. SYNTHETIC COMMUNICATIONS. 42:722-726.
  Full Text via DOI: 10.1080/00397911.2010.530375
- 2012
  
  Analogue-based drug discovery: Contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (Special Topic Article). PURE AND APPLIED CHEMISTRY. 84:1479-1542.
  Full Text via DOI: 10.1351/pac-con-12-02-13
- 2011
  
  Hypoxia Activated Prodrugs of a 9-Aza-anthrapyrazole Derivative That Has Promising Anticancer Activity. JOURNAL OF MEDICINAL CHEMISTRY. 54:8224-8227.
  Full Text via DOI: 10.1021/jm200984x
- 2011
  
  Syntheses of 2,3-Diarylated 2H-Benzo[e][1,2]Thiazine 1,1-Dioxides and their 3,4-Dihydro Derivatives, and Assessment of their Inhibitory Activity Against MCF-7 Breast Cancer Cells. MEDICINAL CHEMISTRY. 7:561-571.
- 2011
  
  Multigram Synthesis of Glyceollin I. ORGANIC PROCESS RESEARCH & DEVELOPMENT. 15:1149-1162.
  Full Text via DOI: 10.1021/op200112g
- 2011
  
  Total Syntheses of (+/-)-Vestitol and Bolusanthin III Using a Wittig Strategy. SYNLETT. 1605-1607.
  Full Text via DOI: 10.1055/s-0030-1260783
- 2011
  
  Biomimetic Syntheses and Antiproliferative Activities of Racemic, Natural (-), and Unnnatural (+) Glyceollin I. JOURNAL OF MEDICINAL CHEMISTRY. 54:3506-3523.
  Full Text via DOI: 10.1021/jm101619e
- 2011
  
  Syntheses of 2,3-Diarylated 2H-Benzo[e][1,2]Thiazine 1,1-Dioxides and their 3,4-Dihydro Derivatives, and Assessment of their Inhibitory Activity Against MCF-7 Breast Cancer Cells. MEDICINAL CHEMISTRY. 7:561-571.
  Full Text via DOI: 10.2174/157340611797928307
- 2010
  
  Theoretical Studies of Salt-Bridge Formation by Amino Acid Side Chains in Low and Medium Polarity Environments. JOURNAL OF PHYSICAL CHEMISTRY B. 114:16436-16442.
  Full Text via DOI: 10.1021/jp103313s
- 2010
  
  Glyceollin I enantiomers distinctly regulate ER-mediated gene expression. STEROIDS. 75:870-878.
  Full Text via DOI: 10.1016/j.steroids.2010.05.007
- 2010
  
  Determination of esmolol and metabolite enantiomers within human plasma using chiral column chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 878:2449-2452.
  Full Text via DOI: 10.1016/j.jchromb.2010.07.006
- 2009
  
  Total Syntheses of Racemic and Natural Glycinol. JOURNAL OF NATURAL PRODUCTS. 72:2072-2075.
  Full Text via DOI: 10.1021/np900509f
- 2009
  
  Monte Carlo structure simulations for tertiary-butyl alcohol solutions in water/acetonitrile solvents. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM. 895:116-126.
  Full Text via DOI: 10.1016/j.theochem.2008.10.026
- 2008
  
  Total Syntheses of Racemic, Natural (-) and Unnatural (+) Glyceollin I.. ORGANIC LETTERS. 10:5007-5010.
  Full Text via DOI: 10.1021/ol802112r
- 2008
  
  Catalytically active peptidylglycine alpha-amidating monooxygenase in the media of androgen-independent prostate cancer cell lines. JOURNAL OF BIOMOLECULAR SCREENING. 13:804-809.
  Full Text via DOI: 10.1177/1087057108321976
- 2008
  
  Rapid and sensitive HPLC assay for simultaneous determination of procaine and para-aminobenzoic acid from human and rat liver tissue extracts. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 867:247-252.
  Full Text via DOI: 10.1016/j.jchromb.2008.04.014
- 2008
  
  Ab initio study of hydrogen-bond formation between aliphatic and phenolic hydroxy groups and selected amino acid side chains. JOURNAL OF PHYSICAL CHEMISTRY A. 112:4342-4354.
  Full Text via DOI: 10.1021/jp7108847
- 2008
  
  Practical synthesis of lespedezol A(1). JOURNAL OF NATURAL PRODUCTS. 71:275-277.
  Full Text via DOI: 10.1021/np070493m
- 2007
  
  Total synthesis of xanthohumol. JOURNAL OF NATURAL PRODUCTS. 70:1507-1509.
  Full Text via DOI: 10.1021/np070158y
- 2007
  
  Simultaneous determination of procaine and para-aminobenzoic acid by LC-MS/MS method. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 847:224-230.
  Full Text via DOI: 10.1016/j.jchromb.2006.10.004
- 2007
  
  Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A. 1138:101-108.
  Full Text via DOI: 10.1016/j.chroma.2006.10.038
- 2006
  
  Ab initio study of hydrogen-bond formation between cyclic ethers and selected amino acid side chains. JOURNAL OF PHYSICAL CHEMISTRY A. 110:13923-13932.
  Full Text via DOI: 10.1021/jp061113t
- 2006
  
  Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis. CLINICAL CANCER RESEARCH. 12:7159-7164.
  Full Text via DOI: 10.1158/1078-0432.CCR-06-1426
- 2006
  
  Simultaneous determination of vinclozolin and detection of its degradation products in mouse plasma, serum and urine, and from rabbit bile, by high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A. 1115:8-18.
  Full Text via DOI: 10.1016/j.chroma.2006.02.062
- 2006
  
  Antiestrogenic Glyceollins Suppress Human Breast and Ovarian Carcinoma Tumorigenesis. CLINICAL CANCER RESEARCH. 12:7159-7164.
  Full Text via DOI: 10.1158/1078-0432.ccr-06-1426
- 2005
  
  Monte Carlo simulations of the solution structure of simple alcohols in water-acetonitrile mixtures. JOURNAL OF PHYSICAL CHEMISTRY B. 109:5855-5872.
- 2005
  
  Monte Carlo Simulations of the Solution Structure of Simple Alcohols in Water−Acetonitrile Mixtures. JOURNAL OF PHYSICAL CHEMISTRY B. 109:5855-5872.
  Full Text via DOI: 10.1021/jp045570q
- 2002
  
  Microplate Screening of the Differential Effects of Test Agents on Hoechst 33342, Rhodamine 123, and Rhodamine 6G Accumulation in Breast Cancer Cells that Overexpress P–Glycoprotein. JOURNAL OF BIOMOLECULAR SCREENING. 7:29-34.
  Full Text via DOI: 10.1089/108705702753520314
- 2002
  
  SELECTIVE CONVERSION OF 2′,7-BIS-MONOCHLOROACETYLPACLITAXEL ANALOGS TO 7-MONOCHLOROACETYL DERIVATIVES BY SOLVOLYSIS IN METHANOL. SYNTHETIC COMMUNICATIONS. 32:2711-2718.
  Full Text via DOI: 10.1081/scc-120006037
- 2001
  
  Mechanistic considerations pertaining to the solvolysis of paclitaxel analogs bearing ester groups at the C2′ position. TETRAHEDRON LETTERS. 42:7747-7750.
  Full Text via DOI: 10.1016/s0040-4039(01)01643-4
- 2000
  
  A Convenient Synthesis of 2-Phenylglycerol. SYNTHETIC COMMUNICATIONS. 30:4027-4038.
  Full Text via DOI: 10.1080/00397910008087018
- 1997
  
  Utilization of a Benzoyl Migration To Effect an Expeditious Synthesis of the Paclitaxel C-13 Side Chain. ORGANIC PROCESS RESEARCH & DEVELOPMENT. 1:387-390.
  Full Text via DOI: 10.1021/op970113b
- 1995
  
  Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle. JOURNAL OF MEDICINAL CHEMISTRY. 38:2119-2129.
  Full Text via DOI: 10.1021/jm00012a011
- 1993
  
  (Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase. JOURNAL OF MEDICINAL CHEMISTRY. 36:1041-1047.
  Full Text via DOI: 10.1021/jm00060a012
- 1992
  
  Cardiotonic agents. 7. Prodrug derivatives of 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2-one. JOURNAL OF MEDICINAL CHEMISTRY. 35:1267-1272.
  Full Text via DOI: 10.1021/jm00085a014
- 1991
  
  Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogs. JOURNAL OF MEDICINAL CHEMISTRY. 34:2671-2677.
  Full Text via DOI: 10.1021/jm00113a002
- 1991
  
  Synthesis and biological activity of angiotensin II analog containing a Val-His replacement, Val.psi.[CH(CONH2)HN]His. JOURNAL OF MEDICINAL CHEMISTRY. 34:2402-2410.
  Full Text via DOI: 10.1021/jm00112a014
- 1990
  
  Cardiotonic agents. 6. Histamine analogs as potential cardiovascular selective H2 agonists. JOURNAL OF MEDICINAL CHEMISTRY. 33:1688-1697.
  Full Text via DOI: 10.1021/jm00168a024
- 1989
  
  Cardiotonic agents. 5. Fragments from the heterocycle-phenyl-imidazole pharmacophore. JOURNAL OF MEDICINAL CHEMISTRY. 32:1173-1176.
  Full Text via DOI: 10.1021/jm00126a005
- 1989
  
  Heterocyclic analogs of benzamide antiarrhythmic agents. JOURNAL OF MEDICINAL CHEMISTRY. 32:688-693.
  Full Text via DOI: 10.1021/jm00123a033
- 1988
  
  Theoretical investigations of methanesulphonamide as a hydroxy group equivalent in drugs. Examples from possible β-adrenergic agents and analysis of computational methods. J. Chem. Soc., Perkin Trans. 2. 437-442.
  Full Text via DOI: 10.1039/p29880000437
- 1987
  
  Cardiotonic agents. 1. Novel 8-aryl substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo[1,5-a]pyridinones as potential positive inotropic agents. JOURNAL OF MEDICINAL CHEMISTRY. 30:1337-1342.
  Full Text via DOI: 10.1021/jm00391a012
- 1987
  
  Cardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents. JOURNAL OF MEDICINAL CHEMISTRY. 30:1342-1347.
  Full Text via DOI: 10.1021/jm00391a013
- 1987
  
  Facile Formation of Quaternary Azetidinium Compounds During Triflation of Dialkylaminopropanols. SYNTHETIC COMMUNICATIONS. 17:469-475.
  Full Text via DOI: 10.1080/00397918708063926
- 1987
  
  In search of the digitalis replacement. JOURNAL OF MEDICINAL CHEMISTRY. 30:231-237.
  Full Text via DOI: 10.1021/jm00385a001
- 1987
  
  β-Methylsulfonylamino phenethylamines and aryloxypropylamines as potential β-adrenergic agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 22:165-167.
  Full Text via DOI: 10.1016/0223-5234(87)90014-6
- 1983
  
  Benzylamine and Dibenzylamine Revisited. Syntheses of N-Substituted Aryloxypropanolamines Exemplifying a General Route to Secondary Aliphatic Amines. SYNTHETIC COMMUNICATIONS. 13:103-114.
  Full Text via DOI: 10.1080/00397918308061967
- 1983
  
  Ultra-short-acting .beta.-adrenergic receptor blocking agents. 3. Ethylenediamine derivatives of (aryloxy)propanolamines having esters on the aryl function. JOURNAL OF MEDICINAL CHEMISTRY. 26:1109-1112.
  Full Text via DOI: 10.1021/jm00362a004
- 1982
  
  Ultra-short acting beta-blockers: A proposal for the treatment of the critically ill patient. LIFE SCIENCES. 31:899-907.
  Full Text via DOI: 10.1016/0024-3205(82)90547-1
- 1982
  
  Ultra-short-acting .beta.-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent. JOURNAL OF MEDICINAL CHEMISTRY. 25:1402-1407.
  Full Text via DOI: 10.1021/jm00354a002
- 1982
  
  Ultra-short-acting .beta.-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function. JOURNAL OF MEDICINAL CHEMISTRY. 25:1408-1412.
  Full Text via DOI: 10.1021/jm00354a003
- 1980
  
  Topographical Model of the Renal Vascular Dopamine Receptor. JOURNAL OF PHARMACEUTICAL SCIENCES. 69:1059-1061.
  Full Text via DOI: 10.1002/jps.2600690919
Book Chapter (Web of Science)
- 2013
  
  Glossary of Terms Used in Medicinal Chemistry Part II (IUPAC Recommendations 2013). ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 48. 387-418.
  Full Text via DOI: 10.1016/B978-0-12-417150-3.00024-7
Chapter (Faculty180)
- 2010
  
  Prodrugs: Strategic Deployment, Metabolic Considerations and Chemical Design Principles. Burger’s Medicinal Chemistry and Drug Discovery (7th Ed.). Wiley-Interscience.
Correction (Web of Science)
- 2017
  
  Correction: Corrigendum: Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα. NATURE COMMUNICATIONS. 16124.
  Full Text via DOI: 10.1038/ncomms16124
- 2003
  
  Corrigendum to “Mechanistic considerations pertaining to the solvolysis of paclitaxel analogs bearing ester groups at the C2′ position”. TETRAHEDRON LETTERS. 1985.
  Full Text via DOI: 10.1016/s0040-4039(03)00106-0
- 1987
  
  Additions and Corrections - In Search of the Digitalis Replacement. JOURNAL OF MEDICINAL CHEMISTRY. 1938-1938.
  Full Text via DOI: 10.1021/jm00393a600
Editorial Material (Web of Science)
- 2000
  
  Medicinal chemistry in the development of societies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 1121-1125.
  Full Text via DOI: 10.1016/s0223-5234(00)01196-x
Meeting Abstract (Web of Science)
- 2019
  
  Abstract 2955: Development of non-apoptotic, caspase-independent cell death inducers against cancer cells
  Full Text via DOI: 10.1158/1538-7445.am2019-2955
- 2018
  
  Abstract LB-080: Discovery of an unconventional form of cell-death in colorectal cancer
  Full Text via DOI: 10.1158/1538-7445.am2018-lb-080
- 2016
  
  Translating molecular biology and clinical concepts into useful therapeutic agents within an academic-based drug discovery and development center: Importance of practical business considerations and extramural collaborations as well as meritorious technologies. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2016
  
  Abstract 1244: A novel microtubule-disrupting indole-based chalcone that induces caspase-independent cell death in glioblastoma and melanoma cells
  Full Text via DOI: 10.1158/1538-7445.am2016-1244
- 2013
  
  Design and development of glyceollin derived anti-cancer agents. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2013
  
  Indole-based chalcones as inducers of Methuosis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2013
  
  Synthesis of soy phytoalexins having anti-cancer properties. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2012
  
  Design, synthesis, and biological evaluation of new species-selective inhibitors of aspartate semialdehyde dehydrogenase. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2011
  
  Molecular docking and 3D-QSAR studies for design and development of selective aspartate semialdehyde dehydrogenase inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2011
  
  Synthesis and structure-activity relationships of compounds that induce methuosis, a novel type of non-apoptotic cell death. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2011-666
- 2011
  
  Abstract 666: Synthesis and structure-activity relationships of compounds that induce methuosis, a novel type of non-apoptotic cell death
  Full Text via DOI: 10.1158/1538-7445.am2011-666
- 2010
  
  Synthetic scale-up and process optimization of glyceollin I, a novel natural product that displays interesting anticancer activity. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2010
  
  Total synthesis of racemic and natural glyceollin II. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2009
  
  ORGN 266-Ultrasound imaging for breast cancer. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.
- 2005
  
  Glyceollins (I-III), novel anti-estrogenic phytochemicals isolated from soy. BREAST CANCER RESEARCH AND TREATMENT. S202-S202.
Note (Web of Science)
- 1988
  
  Cardiotonic agents 4. Dimaprit analogues as potential cardiovascular selective H2-agonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 295-300.
  Full Text via DOI: 10.1016/0223-5234(88)90013-x
- 1980
  
  Analysis of procainamide hydrochloride and acecainide hydrochloride in rat feed. JOURNAL OF PHARMACEUTICAL SCIENCES. 1439-1440.
  Full Text via DOI: 10.1002/jps.2600691224
Patent (Faculty180)
- 2013
  
  Methods for Synthesizing Glycinols, Glyceollins I and II, Compositions of Selected Intermediates, and Therapeutic Uses Thereof
- 2005
  
  Selective Removal of Acyl-Functionality
Review Article (Web of Science)
- 2013
  
  Glossary of Terms Used in Medicinal Chemistry Part II (IUPAC Recommendations 2013). Annual Reports in Medicinal Chemistry. 387-418.
  Full Text via DOI: 10.1016/b978-0-12-417150-3.00024-7
- 2003
  
  A Human Drug Metabolism Database: Potential Roles in the Quantitative Predictions of Drug Metabolism and Metabolism-Related Drug-Drug Interactions. CURRENT DRUG METABOLISM. 411-422.
  Full Text via DOI: 10.2174/1389200033489299
- 2002
  
  Medicinal chemistry in the new millennium. A glance into the future. PURE AND APPLIED CHEMISTRY. 703-785.
  Full Text via DOI: 10.1351/pac200274050703
- 1991
  
  A topographical model for the c-AMP phosphodiesterase III active site. LIFE SCIENCES. 553-568.
  Full Text via DOI: 10.1016/0024-3205(91)90254-9

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Paul W Erhardt

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