Shemshedini, Lirim

Lirim Shemshedini
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Positions

Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

lirim.shemshedini@utoledo.edu

selected publications

Article (Faculty180)
- 2024
  
  MDM2 regulates the stability of AR, AR-V7, and TM4SF3 proteins in prostate cancer. Endocrine oncology (Bristol, England). 4:e230017.
- 2023
  
  Identifying dual acting small molecule inhibitors for potential treatment of castration-resistant prostate cancer. Results in Chemistry. 6:101058.
- 2023
  
  Peptides disrupting TM4SF3 interaction with AR or AR-V7 block prostate cancer cell proliferation. Endocrine oncology (Bristol, England). 3:e230010.
- 2023
  
  The Transmembrane Protein TM4SF3 Interacts With AR and AR-V7 and is Recruited to AR Target Genes. Endocrinology. 164.
- 2022
  
  Dual-Acting Peptides Target EZH2 and AR: A New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer. Endocrinology. 164.
- 2020
  
  Androgen up-regulation of Twist1 gene expression is mediated by ETV1. PeerJ. 8:e8921.
- 2017
  
  Peptide B targets soluble guanylyl cyclase α1 and kills prostate cancer cells. PloS one. 12:e0184088.
- 2017
  
  RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells. International journal of molecular sciences. 18.
- 2016
  
  TM4SF3 and AR: A Nuclear Complex that Stabilizes Both Proteins. Molecular endocrinology (Baltimore, Md.). 30:13-25.
- 2014
  
  COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells. Molecular endocrinology (Baltimore, Md.). 28:834-45.
- 2013
  
  A peptide against soluble guanylyl cyclase α1: a new approach to treating prostate cancer. PloS one. 8:e64189.
- 2013
  
  Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells. PloS one. 8:e78766.
- 2012
  
  Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer. Molecular endocrinology (Baltimore, Md.). 26:292-307.
- 2010
  
  FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene. 29:1691-701.
- 2009
  
  Use of reporter genes to study promoters of the androgen receptor. Methods in molecular biology (Clifton, N.J.). 590:195-207.
- 2008
  
  Expression of a hyperactive androgen receptor leads to androgen-independent growth of prostate cancer cells. Journal of molecular endocrinology. 41:13-23.
- 2007
  
  Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells. Prostate cancer and prostatic diseases. 10:39-45.
- 2007
  
  Androgen regulation of soluble guanylyl cyclasealpha1 mediates prostate cancer cell proliferation. Oncogene. 26:1606-15.
- 2007
  
  ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Molecular endocrinology (Baltimore, Md.). 21:1835-46.
- 2007
  
  c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. Molecular cancer research : MCR. 5:725-35.
- 2006
  
  Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription. Endocrine. 29:363-73.
- 2006
  
  SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. The Journal of biological chemistry. 281:4002-12.
- 2006
  
  c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation. Oncogene. 25:7212-23.
- 2004
  
  Glycogen synthase kinase-3 beta is involved in the phosphorylation and suppression of androgen receptor activity. The Journal of biological chemistry. 279:19191-200.
- 2001
  
  c-Jun potentiates the functional interaction between the amino and carboxyl termini of the androgen receptor. The Journal of biological chemistry. 276:44704-11.
- 2001
  
  p53 represses androgen-induced transactivation of prostate-specific antigen by disrupting hAR amino- to carboxyl-terminal interaction. The Journal of biological chemistry. 276:38472-9.
- 2000
  
  c-Jun targets amino terminus of androgen receptor in regulating androgen-responsive transcription. Endocrine. 13:55-62.
- 1999
  
  Ligand-activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/c-Fos dimerization. Molecular endocrinology (Baltimore, Md.). 13:276-85.
- 1999
  
  Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription. Endocrine. 10:281-9.
- 1998
  
  Identification of domains of c-Jun mediating androgen receptor transactivation. Oncogene. 16:2001-9.
- 1998
  
  c-Fos dimerization with c-Jun represses c-Jun enhancement of androgen receptor transactivation. Endocrine. 9:193-200.
- 1996
  
  c-Jun can mediate androgen receptor-induced transactivation. The Journal of biological chemistry. 271:24583-9.
- 1996
  
  pLEF, a novel vector for expression of glutathione S-transferase fusion proteins in mammalian cells. Gene. 169:281-2.
- 1994
  
  Pure and functionally homogeneous recombinant retinoid X receptor. The Journal of biological chemistry. 269:25770-6.
- 1992
  
  In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors. The Journal of biological chemistry. 267:1834-9.
- 1991
  
  Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors. The EMBO journal. 10:3839-49.
- 1990
  
  Evidence for a juvenile hormone receptor involved in protein synthesis in Drosophila melanogaster. The Journal of biological chemistry. 265:1913-8.
- 1990
  
  Resistance to juvenile hormone and an insect growth regulator in Drosophila is associated with an altered cytosolic juvenile hormone-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 87:2072-6.
Article (Web of Science)
- 2020
  
  Androgen up-regulation of Twist1 gene expression is mediated by ETV1. PEERJ. 8.
  Full Text via DOI: 10.7717/peerj.8921 PMID: 32296610
- 2017
  
  Peptide B targets soluble guanylyl cyclase alpha 1 and kills prostate cancer cells. PLOS ONE. 12.
  Full Text via DOI: 10.1371/journal.pone.0184088
- 2017
  
  RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 18.
  Full Text via DOI: 10.3390/ijms18030529
- 2016
  
  TM4SF3 and AR: A Nuclear Complex that Stabilizes Both Proteins. MOLECULAR ENDOCRINOLOGY. 30:13-25.
  Full Text via DOI: 10.1210/me.2015-1075
- 2014
  
  COP9 Subunits 4 and 5 Target Soluble Guanylyl Cyclase alpha 1 and p53 in Prostate Cancer Cells. MOLECULAR ENDOCRINOLOGY. 28:834-845.
  Full Text via DOI: 10.1210/me.2014-1017
- 2013
  
  Zinc Finger 280B Regulates sGC alpha 1 and p53 in Prostate Cancer Cells. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0078766
- 2013
  
  A Peptide against Soluble Guanylyl Cyclase alpha 1: A New Approach to Treating Prostate Cancer. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0064189
- 2012
  
  Soluble Guanylyl Cyclase alpha 1 and p53 Cytoplasmic Sequestration and Down-Regulation in Prostate Cancer. MOLECULAR ENDOCRINOLOGY. 26:292-307.
  Full Text via DOI: 10.1210/me.2010-0394
- 2010
  
  FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. ONCOGENE. 29:1691-1701.
  Full Text via DOI: 10.1038/onc.2009.458
- 2010
  
  C/EBPα redirects androgen receptor signaling through a unique bimodal interaction. ONCOGENE. 29:723-738.
  Full Text via DOI: 10.1038/onc.2009.373
- 2008
  
  Expression of a hyperactive androgen receptor leads to androgen-independent growth of prostate cancer cells. JOURNAL OF MOLECULAR ENDOCRINOLOGY. 41:13-23.
  Full Text via DOI: 10.1677/JME-07-0158
- 2008
  
  Expression of a hyperactive androgen receptor leads to androgen-independent growth of prostate cancer cells. JOURNAL OF MOLECULAR ENDOCRINOLOGY. 41:13-23.
  Full Text via DOI: 10.1677/jme-07-0158
- 2007
  
  ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. MOLECULAR ENDOCRINOLOGY. 21:1835-1846.
  Full Text via DOI: 10.1210/me.2006-0480
- 2007
  
  c-jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. MOLECULAR CANCER RESEARCH. 5:725-735.
  Full Text via DOI: 10.1158/1541-7786.MCR-06-0430
- 2007
  
  Androgen regulation of soluble guanylyl cyclase alpha 1 mediates prostate cancer cell proliferation. ONCOGENE. 26:1606-1615.
  Full Text via DOI: 10.1038/sj.onc.1209956
- 2007
  
  Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells. PROSTATE CANCER AND PROSTATIC DISEASES. 10:39-45.
  Full Text via DOI: 10.1038/sj.pcan.4500912
- 2007
  
  c-Jun Has Multiple Enhancing Activities in the Novel Cross Talk between the Androgen Receptor and Ets Variant Gene 1 in Prostate Cancer. MOLECULAR CANCER RESEARCH. 5:725-735.
  Full Text via DOI: 10.1158/1541-7786.mcr-06-0430
- 2006
  
  c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation. ONCOGENE. 25:7212-7223.
  Full Text via DOI: 10.1038/sj.onc.1209705
- 2006
  
  Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription. ENDOCRINE. 29:363-373.
- 2006
  
  SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:4002-4012.
  Full Text via DOI: 10.1074/jbc.M509260200
- 2006
  
  Makorin RING Finger Protein 1 (MKRN1) Has Negative and Positive Effects on RNA Polymerase II-Dependent Transcription. Endocrine. 29:363-374.
  Full Text via DOI: 10.1385/endo:29:2:363
- 2006
  
  SUMO-3 Enhances Androgen Receptor Transcriptional Activity through a Sumoylation-independent Mechanism in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:4002-4012.
  Full Text via DOI: 10.1074/jbc.m509260200
- 2004
  
  Glycogen Synthase Kinase-3β Is Involved in the Phosphorylation and Suppression of Androgen Receptor Activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 279:19191-19200.
  Full Text via DOI: 10.1074/jbc.m309560200
- 2001
  
  c-Jun Potentiates the Functional Interaction between the Amino and Carboxyl Termini of the Androgen Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY. 276:44704-44711.
  Full Text via DOI: 10.1074/jbc.m107346200
- 2001
  
  p53 Represses Androgen-induced Transactivation of Prostate-specific Antigen by Disrupting hAR Amino- to Carboxyl-terminal Interaction. JOURNAL OF BIOLOGICAL CHEMISTRY. 276:38472-38479.
  Full Text via DOI: 10.1074/jbc.m103652200
- 2000
  
  c-Jun Targets Amino Terminus of Androgen Receptor in Regulating Androgen-Responsive Transcription. Endocrine. 13:55-62.
  Full Text via DOI: 10.1385/endo:13:1:55
- 1999
  
  Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription. Endocrine. 10:281-289.
  Full Text via DOI: 10.1007/bf02738627
- 1998
  
  Identification of domains of c-Jun mediating androgen receptor transactivation. ONCOGENE. 16:2001-2009.
  Full Text via DOI: 10.1038/sj.onc.1201697
- 1998
  
  c-Fos Dimerization with c-Jun Represses c-Jun Enhancement of Androgen Receptor Transactivation. Endocrine. 9:193-200.
  Full Text via DOI: 10.1385/endo:9:2:193
- 1996
  
  c-Jun Can Mediate Androgen Receptor-induced Transactivation. JOURNAL OF BIOLOGICAL CHEMISTRY. 271:24583-24589.
  Full Text via DOI: 10.1074/jbc.271.40.24583
- 1996
  
  pLEF, a novel vector for expression of glutathione S-transferase fusion proteins in mammalian cells. GENE. 169:281-282.
  Full Text via DOI: 10.1016/0378-1119(95)00820-9
- 1993
  
  Juvenile hormone binding proteins in larval fat body nuclei of Drosophila melanogaster. Journal of Insect Physiology. 39:563-569.
  Full Text via DOI: 10.1016/0022-1910(93)90038-s
- 1991
  
  Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.. EMBO JOURNAL. 10:3839-3849.
  Full Text via DOI: 10.1002/j.1460-2075.1991.tb04953.x
- 1990
  
  Resistance to juvenile hormone and an insect growth regulator in Drosophila is associated with an altered cytosolic juvenile hormone-binding protein.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 87:2072-2076.
  Full Text via DOI: 10.1073/pnas.87.6.2072
- 1988
  
  A high affinity, high molecular weight juvenile hormone binding protein in the hemolymph of Drosophila melanogaster. Insect Biochemistry. 18:681-689.
  Full Text via DOI: 10.1016/0020-1790(88)90077-7
Book Chapter (Web of Science)
- 2009
  
  Use of Reporter Genes to Study Promoters of the Androgen Receptor. Methods in Molecular Biology. 195-207.
  Full Text via DOI: 10.1007/978-1-60327-378-7_12
Meeting Abstract (Web of Science)
- 2020
  
  Abstract 2072: TM4SF3 interaction with AR or AR-V7 is important for the survival of prostate cancer cells
  Full Text via DOI: 10.1158/1538-7445.am2020-2072
- 2011
  
  Soluble guanylyl cyclase alpha 1 and p53 cytoplasmic sequestration: A novel mechanism for p53 down-regulation in prostate cancer. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2011-215
- 2011
  
  Abstract 215: Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration: A novel mechanism for p53 down-regulation in prostate cancer
  Full Text via DOI: 10.1158/1538-7445.am2011-215

full name

Lirim Shemshedini

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Cumulative publications in Scholars@UToledo

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