Kam C Yeung
- Associate Professor, Biochemistry and Cancer Biology , College of Medicine and Life Sciences
Publications
selected publications
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Article (Web of Science)
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2021The RhoA dependent anti-metastatic function of RKIP in breast cancer. SCIENTIFIC REPORTS. 11.Full Text via DOI: 10.1038/s41598-021-96709-6 PMID: 34465801
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2019Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-52746-w PMID: 31705019
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2019Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGF beta. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-43239-x PMID: 31040372
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2019Critical role of miR-10b in B-Raf(V600E) dependent anchorage independent growth and invasion of melanoma cells. PLOS ONE. 14.Full Text via DOI: 10.1371/journal.pone.0204387 PMID: 30995246
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2015
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2015RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. PLOS ONE. 10.Full Text via DOI: 10.1371/journal.pone.0134494
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2015Raf Kinase Inhibitor Protein (RKIP) Deficiency Decreases Latency of Tumorigenesis and Increases Metastasis in a Murine Genetic Model of Prostate Cancer. PROSTATE. 75:292-302.Full Text via DOI: 10.1002/pros.22915
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2015RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration. ONCOTARGET. 6:39050-39061.Full Text via DOI: 10.18632/oncotarget.5176
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2014Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:E364-E373.Full Text via DOI: 10.1073/pnas.1304840111
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2013SWI/SNF Enzymes Promote SOX10-Mediated Activation of Myelin Gene Expression. PLOS ONE. 8.Full Text via DOI: 10.1371/journal.pone.0069037
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2013Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer. AMERICAN JOURNAL OF CANCER RESEARCH. 3:446-464.
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2012Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer. CANCER RESEARCH. 72:3091-3104.Full Text via DOI: 10.1158/0008-5472.CAN-11-3546
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2012A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance. PLOS ONE. 7.Full Text via DOI: 10.1371/journal.pone.0029532
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2012Transcriptional Regulation of RKIP Expression by Androgen in Prostate Cells. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 30:1340-1350.Full Text via DOI: 10.1159/000343323
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2012Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer. CANCER RESEARCH. 72:3091-3104.Full Text via DOI: 10.1158/0008-5472.can-11-3546
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2010Raf kinase inhibitor protein suppresses nuclear factor-kappa B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. CANCER LETTERS. 299:137-149.Full Text via DOI: 10.1016/j.canlet.2010.08.012
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2010RKIP inhibits NF-kappa B in cancer cells by regulating upstream signaling components of the I kappa B kinase complex. FEBS LETTERS. 584:662-668.Full Text via DOI: 10.1016/j.febslet.2009.12.051
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2009Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization. CANCER RESEARCH. 69:8376-8385.Full Text via DOI: 10.1158/0008-5472.CAN-09-1069
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2009Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization. CANCER RESEARCH. 69:8376-8385.Full Text via DOI: 10.1158/0008-5472.can-09-1069
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2008Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 72:153-160.Full Text via DOI: 10.1016/j.ijrobp.2008.04.072
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2008The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. CELLULAR SIGNALLING. 20:935-941.Full Text via DOI: 10.1016/j.cellsig.2008.01.012
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2008Snail is a repressor of RK1P transcription in metastatic prostate cancer cells. ONCOGENE. 27:2243-2248.Full Text via DOI: 10.1038/sj.onc.1210860
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2008Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion. JOURNAL OF CELLULAR BIOCHEMISTRY. 103:972-985.Full Text via DOI: 10.1002/jcb.21470
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2007Raf kinase inhibitory protein knockout mice: Expression in the brain and olfaction deficit. BRAIN RESEARCH BULLETIN. 71:559-567.Full Text via DOI: 10.1016/j.brainresbull.2006.11.010
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Correction (Web of Science)
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2016RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration (vol 6, pg 39050, 2015). ONCOTARGET. 26925-26925.Full Text via DOI: 10.18632/oncotarget.9139
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Meeting Abstract (Web of Science)
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2014Effect of RKIP on MMP expression and regulation of breast cancer metastasis. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2014-124
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2013BACH1 and RKIP participate in a bistable network that affects progression to metastasis in breast Cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.FBCR13-A39
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2012Molecular regulation of RKIP, a tumor metastasis suppressor in breast cancer. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2012-3433
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2011Inhibition of the metastasis suppressor RKIP by EZH2 and YY1. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2011-2162
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2010Dual role of NO donors in the reversal of tumor cell resistance and EMT: dysregulation of the NF-kappa B/YY1/Snail/RKIP circuitry. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. S18-S18.Full Text via DOI: 10.1016/j.niox.2010.05.047
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2009A molecular cross-talk cell signaling circuitry regulates tumor resistance and metastasis: identification of novel therapeutic small molecules that reverse these phenotypes. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. S57-S57.
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2007Induction of Raf-1 Kinase Inhibitory Protein (RKIP) by the Proteasome Inhibitor NPI-0052 and Reversal of B-NHL Resistance to Apoptosis.. BLOOD. 809-809.Full Text via DOI: 10.1182/blood.v110.11.809.809
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Review Article (Web of Science)
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2013RKIP: Much more than Raf Kinase inhibitory protein. JOURNAL OF CELLULAR PHYSIOLOGY. 1688-1702.Full Text via DOI: 10.1002/jcp.24335
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2012Raf kinase inhibitor protein (RKIP) in cancer. CANCER AND METASTASIS REVIEWS. 615-620.Full Text via DOI: 10.1007/s10555-012-9365-9
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2008Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 152-157.Full Text via DOI: 10.1016/j.niox.2008.04.018
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2007Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation. JOURNAL OF IMMUNOLOGY. 5441-5453.Full Text via DOI: 10.4049/jimmunol.179.8.5441
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Contact
full name
- Kam C Yeung
visualizations
Cumulative publications in Scholars@UToledo