Yeung, Kam C

Kam C Yeung
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Positions

Associate Professor, Biochemistry and Cancer Biology , College of Medicine and Life Sciences

Contact Info

Kam.Yeung@utoledo.edu

http://www.utoledo.edu/med/depts/cancer-biology/faculty/yeung.html

selected publications

Article (Faculty180)
- 2023
  
  Changes in Expression of Tumor Suppressor Gene RKIP Impact How Cancers Interact with Their Complex Environment. Cancers. 15.
- 2023
  
  RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression. The Journal of biological chemistry. 299:103023.
- 2019
  
  Reduced Basal Nitric oxide production Induces precancerous Mammary Lesions via ERBB2 and tGF$beta$. Scientific reports. 9:6688.
- 2016
  
  RAF KINASE INHIBITOR PROTEIN (RKIP) EXPRESSION IN MELANOCYTIC LESIONS MAY INHIBIT MELANOMA PROGRESSION: STUDY IN A GENETICALLY ENGINEERED MELANOMA PRONE MOUSE MODEL. Journal of Cutaneous Pathology. 43.
- 2015
  
  Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer. The Prostate. 75:292.
- 2014
  
  Genetic and epigenetic control of RKIP transcription. Critical Reviews™ in Oncogenesis. 19.
- 2014
  
  Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. Proceedings of the National Academy of Sciences. 111:E364.
- 2014
  
  Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. PLoS One. 9:e92478.
- 2013
  
  Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer. American journal of cancer research. 3:446.
- 2013
  
  RKIP: much more than Raf kinase inhibitory protein. Journal of cellular physiology. 228:1688.
- 2012
  
  A Micro-RNA Connection in 𝐁 𝐑 𝐚 𝐟 𝐕 𝟔 𝟎 𝟎 𝐄-Mediated Premature Senescence of Human Melanocytes. International Journal of Cell Biology. 2012.
- 2012
  
  A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. PLoS One. 7:e29532.
- 2012
  
  Raf kinase inhibitor protein (RKIP) in cancer. Cancer and Metastasis Reviews. 31:615.
- 2012
  
  Transcriptional regulation of RKIP expression by androgen in prostate cells. Cellular Physiology and Biochemistry. 30:1340.
- 2010
  
  MAP3K7 (mitogen-activated protein kinase kinase kinase 7). Atlas of Genetics and Cytogenetics in Oncology and Haematology.
- 2010
  
  RKIP inhibits NF-$kappa$B in cancer cells by regulating upstream signaling components of the I$kappa$B kinase complex. FEBS letters. 584:662.
- 2010
  
  Raf kinase inhibitor protein suppresses nuclear factor-$kappa$B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer letters. 299:137.
- 2009
  
  Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene. 28:3573.
- 2009
  
  Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization. Cancer research. 69:8376.
- 2008
  
  Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. International Journal of Radiation Oncology* Biology* Physics. 72:153.
- 2008
  
  Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo-and immunosensitization to apoptosis and inhibition of metastases. Nitric oxide. 19:152.
- 2008
  
  PEBP1 (phosphatidylethanolamine binding protein 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology.
- 2008
  
  Raf kinase inhibitor protein positively regulates cell--substratum adhesion while negatively regulating cell--cell adhesion. Journal of cellular biochemistry. 103:972.
- 2008
  
  Snail is a repressor of RKIP transcription in metastatic prostate cancer cells. Oncogene. 27:2243.
- 2008
  
  The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. Cellular signalling. 20:935.
- 2007
  
  B1. Nitric oxide induces RKIP expression and sensitizes tumor cells to TRAIL-mediated apoptosis via inhibition of both NF-$kappa$B and YY1 and upregulation of DR5. Nitric Oxide. 16.
- 2007
  
  B1. Nitric oxide induces RKIP expression and sensitizes tumor cells to TRAIL-mediated apoptosis via inhibition of both NF-kB and YY1 and upregulation of DR5. NITRIC OXIDE-ORLANDO-ACADEMIC PRESS-. 17:16.
- 2007
  
  C15. Therapeutic preclinical application of NO donor (eg DETANONOate) and CDDP in prostate tumor xenograft regression: molecular mechanism of synergy achieved in apoptosis. Nitric Oxide. 23.
- 2007
  
  C35. Nitric oxide mimics rituximab (chimeric anti-CD20 mAb)-induced chemo/immuno-sensitization of resistant B-non Hodgkin's lymphoma. NITRIC OXIDE-ORLANDO-ACADEMIC PRESS-. 17:28.
- 2007
  
  C35. Nitric oxide mimics rituximab (chimeric anti-CD20 mAb)-induced chemo/immuno-sensitization of resistant B-non Hodgkin’s lymphoma. Nitric Oxide. 28.
- 2007
  
  Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit. Brain research bulletin. 71:559.
- 2007
  
  Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation. The Journal of Immunology. 179:5441.
- 2006
  
  Regulation of RKIP binding to the N-region of the Raf-1 kinase. FEBS letters. 580:6405.
- 2005
  
  RKIP downregulates B-Raf kinase activity in melanoma cancer cells. Oncogene. 24:3535.
- 2005
  
  Sensitization of prostate cancer cells to TRAIL-induced apoptosis by CDDP: Involvement of NF-$kappa$B, YY1 and RKIP in upregulation of DR5 expression. Journal of Clinical Oncology. 23:3189.
- 2004
  
  Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N 6 position. FEBS letters. 556:26.
- 2004
  
  RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. Journal of Biological Chemistry. 279:17515.
- 2004
  
  Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene. Cancer letters. 207:131.
- 2001
  
  Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIPshort. Cancer research. 61:7148.
- 2001
  
  Raf kinase inhibitor protein interacts with NF-$kappa$B-inducing kinase and TAK1 and inhibits NF-$kappa$B activation. Molecular and cellular biology. 21:7207.
- 2000
  
  Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Molecular and cellular biology. 20:3079.
- 1999
  
  Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 401:173.
- 1997
  
  Functional dissection of a human Dr1-DRAP1 repressor complex.. Molecular and cellular biology. 17:36.
- 1996
  
  Requirement of a corepressor for Dr1-mediated repression of transcription.. Genes & development. 10:1033.
- 1994
  
  Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A. Proceedings of the National Academy of Sciences. 91:6279.
- 1994
  
  Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription.. Genes & development. 8:2336.
- 1994
  
  Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription.. Genes & Development. 8:2097.
- 1993
  
  Mutations of the human cytomegalovirus immediate-early 2 protein defines regions and amino acid motifs important in transactivation of transcription from the HIV-1 LTR promoter. Virology. 195:786.
- 1991
  
  Differences in the capacity of two herpes simplex virus isolates to spread from eye to brain map to 1610 base pairs of DNA found in the gene for DNA polymerase. Current eye research. 10:31.
- 1991
  
  Genetic mapping and nucleotide sequence analysis of herpes simplex virus (HSV) gene responsible for neuroinvasiveness in mice.
- 1990
  
  Nucleotide sequences responsible for the inability of a herpes simplex virus type 2 strain to grow in human lymphocytes are identical to those responsible for its inability to grow in mouse tissues following ocular infection. Virology. 176:319.
- 1988
  
  Genomic location of bovid herpesvirus type 2 nucleotide sequences homologous to five herpes simplex virus type 1 genes. Virus research. 10:369.
- Mechanism of Suppression of the
- Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the
- Raf kinase inhibitor protein suppresses nuclear factor-jB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression
- Structure-function analysis of the TBP-binding protein Dr1 reveals
Article (Web of Science)
- 2021
  
  The RhoA dependent anti-metastatic function of RKIP in breast cancer. SCIENTIFIC REPORTS. 11.
  Full Text via DOI: 10.1038/s41598-021-96709-6 PMID: 34465801
- 2019
  
  Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-52746-w PMID: 31705019
- 2019
  
  Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGF beta. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-43239-x PMID: 31040372
- 2019
  
  Critical role of miR-10b in B-Raf(V600E) dependent anchorage independent growth and invasion of melanoma cells. PLOS ONE. 14.
  Full Text via DOI: 10.1371/journal.pone.0204387 PMID: 30995246
- 2015
  
  RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration. ONCOTARGET. 6:39050-39061.
- 2015
  
  RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. PLOS ONE. 10.
  Full Text via DOI: 10.1371/journal.pone.0134494
- 2015
  
  Raf Kinase Inhibitor Protein (RKIP) Deficiency Decreases Latency of Tumorigenesis and Increases Metastasis in a Murine Genetic Model of Prostate Cancer. PROSTATE. 75:292-302.
  Full Text via DOI: 10.1002/pros.22915
- 2015
  
  RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration. ONCOTARGET. 6:39050-39061.
  Full Text via DOI: 10.18632/oncotarget.5176
- 2014
  
  Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer. PLOS ONE. 9.
  Full Text via DOI: 10.1371/journal.pone.0092478
- 2014
  
  Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:E364-E373.
  Full Text via DOI: 10.1073/pnas.1304840111
- 2013
  
  SWI/SNF Enzymes Promote SOX10-Mediated Activation of Myelin Gene Expression. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0069037
- 2013
  
  Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer. AMERICAN JOURNAL OF CANCER RESEARCH. 3:446-464.
- 2012
  
  Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer. CANCER RESEARCH. 72:3091-3104.
  Full Text via DOI: 10.1158/0008-5472.CAN-11-3546
- 2012
  
  A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance. PLOS ONE. 7.
  Full Text via DOI: 10.1371/journal.pone.0029532
- 2012
  
  Transcriptional Regulation of RKIP Expression by Androgen in Prostate Cells. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 30:1340-1350.
  Full Text via DOI: 10.1159/000343323
- 2012
  
  Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer. CANCER RESEARCH. 72:3091-3104.
  Full Text via DOI: 10.1158/0008-5472.can-11-3546
- 2010
  
  Raf kinase inhibitor protein suppresses nuclear factor-kappa B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. CANCER LETTERS. 299:137-149.
  Full Text via DOI: 10.1016/j.canlet.2010.08.012
- 2010
  
  RKIP inhibits NF-kappa B in cancer cells by regulating upstream signaling components of the I kappa B kinase complex. FEBS LETTERS. 584:662-668.
  Full Text via DOI: 10.1016/j.febslet.2009.12.051
- 2009
  
  Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization. CANCER RESEARCH. 69:8376-8385.
  Full Text via DOI: 10.1158/0008-5472.CAN-09-1069
- 2009
  
  Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. ONCOGENE. 28:3573-3585.
  Full Text via DOI: 10.1038/onc.2009.214
- 2009
  
  Pivotal Roles of Snail Inhibition and RKIP Induction by the Proteasome Inhibitor NPI-0052 in Tumor Cell Chemoimmunosensitization. CANCER RESEARCH. 69:8376-8385.
  Full Text via DOI: 10.1158/0008-5472.can-09-1069
- 2008
  
  Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 72:153-160.
  Full Text via DOI: 10.1016/j.ijrobp.2008.04.072
- 2008
  
  The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK. CELLULAR SIGNALLING. 20:935-941.
  Full Text via DOI: 10.1016/j.cellsig.2008.01.012
- 2008
  
  Snail is a repressor of RK1P transcription in metastatic prostate cancer cells. ONCOGENE. 27:2243-2248.
  Full Text via DOI: 10.1038/sj.onc.1210860
- 2008
  
  Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion. JOURNAL OF CELLULAR BIOCHEMISTRY. 103:972-985.
  Full Text via DOI: 10.1002/jcb.21470
- 2007
  
  Raf kinase inhibitory protein knockout mice: Expression in the brain and olfaction deficit. BRAIN RESEARCH BULLETIN. 71:559-567.
  Full Text via DOI: 10.1016/j.brainresbull.2006.11.010
Chapter (Faculty180)
- 2020
  
  RKIP Regulation and Crosstalks Regulation of RKIP Expression in Breast Cancer Cells by miRNA. Prognostic and Therapeutic Applications of RKIP in Cancer. Academic Press. 139-146.
- 2008
  
  The RKIP and STAT3 Axis in Cancer Chemotherapy: Opposites Attract. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy. Springer. 159.
Correction (Web of Science)
- 2016
  
  RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration (vol 6, pg 39050, 2015). ONCOTARGET. 26925-26925.
  Full Text via DOI: 10.18632/oncotarget.9139
Meeting Abstract (Web of Science)
- 2018
  
  Abstract 5153: RKIP-RhoA axis inhibits breast cancer invasion and metastasis by increasing E-cadherin expression
  Full Text via DOI: 10.1158/1538-7445.am2018-5153
- 2014
  
  Effect of RKIP on MMP expression and regulation of breast cancer metastasis. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2014-124
- 2014
  
  Abstract 124: Effect of RKIP on MMP expression and regulation of breast cancer metastasis
  Full Text via DOI: 10.1158/1538-7445.am2014-124
- 2013
  
  BACH1 and RKIP participate in a bistable network that affects progression to metastasis in breast Cancer. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.FBCR13-A39
- 2013
  
  Abstract A39: BACH1 and RKIP participate in a bistable network that affects progression to metastasis in breast Cancer
  Full Text via DOI: 10.1158/1538-7445.fbcr13-a39
- 2012
  
  Molecular regulation of RKIP, a tumor metastasis suppressor in breast cancer. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2012-3433
- 2012
  
  Abstract 3433: Molecular regulation of RKIP, a tumor metastasis suppressor in breast cancer
  Full Text via DOI: 10.1158/1538-7445.am2012-3433
- 2011
  
  Inhibition of the metastasis suppressor RKIP by EZH2 and YY1. CANCER RESEARCH.
  Full Text via DOI: 10.1158/1538-7445.AM2011-2162
- 2011
  
  Abstract 2162: Inhibition of the metastasis suppressor RKIP by EZH2 and YY1
  Full Text via DOI: 10.1158/1538-7445.am2011-2162
- 2010
  
  Dual role of NO donors in the reversal of tumor cell resistance and EMT: dysregulation of the NF-kappa B/YY1/Snail/RKIP circuitry. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. S18-S18.
  Full Text via DOI: 10.1016/j.niox.2010.05.047
- 2009
  
  A molecular cross-talk cell signaling circuitry regulates tumor resistance and metastasis: identification of novel therapeutic small molecules that reverse these phenotypes. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. S57-S57.
- 2007
  
  Induction of Raf-1 Kinase Inhibitory Protein (RKIP) by the Proteasome Inhibitor NPI-0052 and Reversal of B-NHL Resistance to Apoptosis.. BLOOD. 809-809.
  Full Text via DOI: 10.1182/blood.v110.11.809.809
- 2007
  
  Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM) Compared to Other Tumor Types: Overexpression of RKIP and a Phosphorylated RKIP Is Common in MM Tumor Cells.. BLOOD. 4852-4852.
  Full Text via DOI: 10.1182/blood.v110.11.4852.4852
Other Scholarly Work (Faculty180)
Proceedings (Faculty180)
Review Article (Web of Science)
- 2013
  
  RKIP: Much more than Raf Kinase inhibitory protein. JOURNAL OF CELLULAR PHYSIOLOGY. 1688-1702.
  Full Text via DOI: 10.1002/jcp.24335
- 2012
  
  Raf kinase inhibitor protein (RKIP) in cancer. CANCER AND METASTASIS REVIEWS. 615-620.
  Full Text via DOI: 10.1007/s10555-012-9365-9
- 2008
  
  Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 152-157.
  Full Text via DOI: 10.1016/j.niox.2008.04.018
- 2007
  
  Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation. JOURNAL OF IMMUNOLOGY. 5441-5453.
  Full Text via DOI: 10.4049/jimmunol.179.8.5441

full name

Kam C Yeung

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