Jian-Ting Zhang
Contact Info
Publications
selected publications
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Article (Web of Science)
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2021Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase. CANCER LETTERS. 509:1-12.Full Text via DOI: 10.1016/j.canlet.2021.03.026 PMID: 33813001
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2021eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis. CANCER LETTERS. 500:11-20.Full Text via DOI: 10.1016/j.canlet.2020.12.009 PMID: 33301799
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2020Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. CANCER LETTERS. 491:97-107.Full Text via DOI: 10.1016/j.canlet.2020.08.002 PMID: 32829010
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2020eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 8.Full Text via DOI: 10.3389/fcell.2020.00753 PMID: 32974334
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2020Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10. CANCER BIOLOGY & MEDICINE. 17:740-752.Full Text via DOI: 10.20892/j.issn.2095-3941.2020.0219
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2020Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. JOURNAL OF MEDICINAL CHEMISTRY. 63:7243-7251.Full Text via DOI: 10.1021/acs.jmedchem.0c00475 PMID: 32421328
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2020Translational regulation of Chk1 expression by eIF3a via interaction with the RNA-binding protein HuR. BIOCHEMICAL JOURNAL. 477:1939-1950.Full Text via DOI: 10.1042/bcj20200025
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2019CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 371:320-326.Full Text via DOI: 10.1124/jpet.119.258392 PMID: 31455631
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2019Single-nucleotide polymorphisms in a short basic motif in the ABC transporter ABCG2 disable its trafficking out of endoplasmic reticulum and reduce cell resistance to anticancer drugs. JOURNAL OF BIOLOGICAL CHEMISTRY. 294:20222-20232.Full Text via DOI: 10.1074/jbc.ra119.008347
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2018Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth. ONCOGENE. 37:2469-2480.Full Text via DOI: 10.1038/s41388-017-0076-0
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2018Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 157:887-897.Full Text via DOI: 10.1016/j.ejmech.2018.08.037
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201714-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2. MOLECULAR CANCER RESEARCH. 15:418-428.Full Text via DOI: 10.1158/1541-7786.mcr-16-0366
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2017APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation. ONCOTARGET. 8:102868-102879.Full Text via DOI: 10.18632/oncotarget.22263
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2017Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model. Journal of Controlled Release. 266:129-139.Full Text via DOI: 10.1016/j.jconrel.2017.09.024
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201614-3-3σ regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. ONCOTARGET. 7:17726-17736.Full Text via DOI: 10.18632/oncotarget.7394
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2016Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. CANCER RESEARCH. 76:453-462.Full Text via DOI: 10.1158/0008-5472.can-15-1874
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2016Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. ONCOGENE. 35:783-792.Full Text via DOI: 10.1038/onc.2015.215
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2015Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase. JOURNAL OF MEDICINAL CHEMISTRY. 58:778-784.Full Text via DOI: 10.1021/jm501543u
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2014A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion. ACS CHEMICAL BIOLOGY. 9:1188-1196.Full Text via DOI: 10.1021/cb500071v
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2014EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and β-catenin activation. ONCOGENE. 33:4156-4163.Full Text via DOI: 10.1038/onc.2013.397
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2014Reversible Epigenetic Regulation of 14-3-3σ Expression in Acquired Gemcitabine Resistance by Uhrf1 and DNA Methyltransferase 1. MOLECULAR PHARMACOLOGY. 86:561-569.Full Text via DOI: 10.1124/mol.114.092544
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2013Determinants of 14-3-3σ Protein Dimerization and Function in Drug and Radiation Resistance. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:31447-31457.Full Text via DOI: 10.1074/jbc.m113.467753
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2013Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production. JOURNAL OF LIPID RESEARCH. 54:776-785.Full Text via DOI: 10.1194/jlr.m033811
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2013Overexpression of Asparagine Synthetase and Matrix Metalloproteinase 19 Confers Cisplatin Sensitivity in Nasopharyngeal Carcinoma Cells. MOLECULAR CANCER THERAPEUTICS. 12:2157-2166.Full Text via DOI: 10.1158/1535-7163.mct-12-1190
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2013Spectrin Domain of Eukaryotic Initiation Factor 3a Is the Docking Site for Formation of the a:b:i:g Subcomplex. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:27951-27959.Full Text via DOI: 10.1074/jbc.m113.483164
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2013Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a. Carcinogenesis. 34:1224-1231.Full Text via DOI: 10.1093/carcin/bgt052
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2012Different Roles of TM5, TM6, and ECL3 in the Oligomerization and Function of Human ABCG2. BIOCHEMISTRY. 51:3634-3641.Full Text via DOI: 10.1021/bi300301a
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2011Critical Residue That Promotes Protein Dimerization: A Story of Partially Exposed Phe25 in 14-3-3σ. Journal of Chemical Information and Modeling. 51:2612-2625.Full Text via DOI: 10.1021/ci200212y
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2011Effect of eIF3a on Response of Lung Cancer Patients to Platinum-Based Chemotherapy by Regulating DNA Repair. CLINICAL CANCER RESEARCH. 17:4600-4609.Full Text via DOI: 10.1158/1078-0432.ccr-10-2591
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2011Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma. ONCOGENE. 30:4814-4823.Full Text via DOI: 10.1038/onc.2011.189
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2010Identification of Novel Small Molecule Inhibitors of the XPA Protein Using in Silico Based Screening. ACS CHEMICAL BIOLOGY. 5:953-965.Full Text via DOI: 10.1021/cb1000444
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2010Role of Transmembrane Segment 5 and Extracellular Loop 3 in the Homodimerization of Human ABCC1. BIOCHEMISTRY. 49:10854-10861.Full Text via DOI: 10.1021/bi101350x
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2009Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population. PHARMACOGENETICS AND GENOMICS. 19:206-216.Full Text via DOI: 10.1097/fpc.0b013e328323f680
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2009Role of eIF3a in regulating cell cycle progression. EXPERIMENTAL CELL RESEARCH. 315:1889-1894.Full Text via DOI: 10.1016/j.yexcr.2009.03.009
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2008A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction. MOLECULAR CANCER THERAPEUTICS. 7:263-270.Full Text via DOI: 10.1158/1535-7163.mct-07-0445
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2008Effect of Cysteine Mutagenesis on the Function and Disulfide Bond Formation of Human ABCG2. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 326:33-40.Full Text via DOI: 10.1124/jpet.108.138115
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2007Oligomerization Domain of the Multidrug Resistance–Associated Transporter ABCG2 and Its Dominant Inhibitory Activity. CANCER RESEARCH. 67:4373-4381.Full Text via DOI: 10.1158/0008-5472.can-06-3169
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2007Regulation of Function by Dimerization through the Amino-terminal Membrane-spanning Domain of Human ABCC1/MRP1. JOURNAL OF BIOLOGICAL CHEMISTRY. 282:8821-8830.Full Text via DOI: 10.1074/jbc.m700152200
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2007Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development. Differentiation. 75:652-661.Full Text via DOI: 10.1111/j.1432-0436.2007.00165.x
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2006The Amino Terminus of the Human Multidrug Resistance Transporter ABCC1 Has a U-shaped Folding with a Gating Function. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:31152-31163.Full Text via DOI: 10.1074/jbc.m603529200
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Correction (Web of Science)
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2021eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation (vol 8, 753, 2020). FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2020.629218 PMID: 33490090
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Meeting Abstract (Web of Science)
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Review Article (Web of Science)
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2018Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?. Pharmacology & Therapeutics. 74-91.Full Text via DOI: 10.1016/j.pharmthera.2018.06.006
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2018eIF3a: A new anticancer drug target in the eIF family. CANCER LETTERS. 81-87.Full Text via DOI: 10.1016/j.canlet.2017.09.055
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2017Targeting survivin for therapeutic discovery: past, present, and future promises. DRUG DISCOVERY TODAY. 1466-1477.Full Text via DOI: 10.1016/j.drudis.2017.05.009
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2011Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments. Bioscience Reports. 1-15.Full Text via DOI: 10.1042/bsr20100077
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2009Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 1049-1063.Full Text via DOI: 10.1517/17425250903124371
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2007Use of arrays to investigate the contribution of ATP-binding cassette transporters to drug resistance in cancer chemotherapy and prediction of chemosensitivity. Cell Research. 311-323.Full Text via DOI: 10.1038/cr.2007.15
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2007Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment. Cancer Treatment Reviews. 741-756.Full Text via DOI: 10.1016/j.ctrv.2007.07.018
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2006Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer. Critical Reviews in Oncology/Hematology. 169-180.Full Text via DOI: 10.1016/j.critrevonc.2006.03.005
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Contact
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- Jian-Ting Zhang
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Cumulative publications in Scholars@UToledo
