Jason F Huntley
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Associate Dean of Faculty Affairs and Development
Primary Director, BSL3/A-BSL3 Laboratory, Medical Microbiology and Immunology , College of Medicine and Life Sciences
Overview
overview
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The Huntley Laboratory at the University of Toledo College of Medicine and Life Sciences studies:
• Host-pathogen interactions, to develop new strategies to prevent bacterial infections, modulate host immune responses, and understand bacterial pathogenesis. The Huntley lab uses Francisella tularensis (tularemia) as a model intracellular pathogen;
• Vaccine development and testing, including live attenuated and recombinant protein vaccines;
• Bacterial surface protein function, focusing on molecules involved in host cell invasion, intracellular survival, and immune evasion;
• Tick-borne diseases, including understanding how bacterial pathogens infect, persist, and are transmitted by ticks to humans.
• Harmful algal bloom (HAB) mitigation strategies, including using beneficial bacterial to degrade HAB toxins (bioremediation).
• Mentoring and education of learners in microbiology and infectious disease research and clinical approaches.
Specialties: bacterial pathogenesis, host-pathogen interactions, microbiology, infectious disease, tick-borne disease, genetics, immunology, vaccine development, molecular biology, biochemistry, outer membrane protein, bacterial envelope
Publications
selected publications
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Article (Faculty180)
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2021A Francisella tularensis L,D-carboxypeptidase plays important roles in cell morphology, envelope integrity, and virulence. Molecular microbiology. 115:1357-1378.
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2021Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Nature communications. 12:3696.
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2020A Chitinase Contributes to Bacterial Persistence and Replication in Two Major U.S. Tick Vectors. Pathogens (Basel, Switzerland). 9.
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2020Mechanisms Affecting the Acquisition, Persistence and Transmission of in Ticks. Microorganisms. 8.
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2020Whole-Genome Sequencing of Bacterial Isolates That Degrade the Cyanobacterial Toxin Microcystin-LR. Microbiology resource announcements. 9.
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2019Isolation and Characterization of Lake Erie Bacteria that Degrade the Cyanobacterial Microcystin Toxin MC-LR. Journal of Great Lakes research. 45:138-149.
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2019Ticks and Tularemia: Do We Know What We Don't Know?. Frontiers in cellular and infection microbiology. 9:146.
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2017The orange spotted cockroach (Blaptica dubia, Serville 1839) is a permissive experimental host for Francisella tularensis. Proceedings of the West Virginia Academy of Science. 89:34-47.
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2016
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2015From the Outside-In: The Francisella tularensis Envelope and Virulence. Frontiers in cellular and infection microbiology. 5:94.
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2015
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2015Revisiting the Gram-negative lipoprotein paradigm. Journal of bacteriology. 197:1705-15.
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2014Identification of disulfide bond isomerase substrates reveals bacterial virulence factors. Molecular microbiology. 94:926-44.
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2014
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2012Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune response. The Journal of biological chemistry. 287:25216-29.
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2010
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2008Characterization of fig operon mutants of Francisella novicida U112. FEMS Microbiol Lett. 285:270-7.
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2008
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2008Targeting QseC signaling and virulence for antibiotic development. Science. 321:1078-80.
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2007Characterization of Francisella tularensis outer membrane proteins. J Bacteriol. 189:561-74.
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2005
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2005
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2003
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Article (Web of Science)
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2021Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. NATURE COMMUNICATIONS. 12.Full Text via DOI: 10.1038/s41467-021-23900-8 PMID: 34140472
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2021A Francisella tularensis L,D-carboxypeptidase plays important roles in cell morphology, envelope integrity, and virulence. MOLECULAR MICROBIOLOGY.Full Text via DOI: 10.1111/mmi.14685 PMID: 33469978
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2020A Francisella tularensis Chitinase Contributes to Bacterial Persistence and Replication in Two Major U.S. Tick Vectors. PATHOGENS. 9.Full Text via DOI: 10.3390/pathogens9121037 PMID: 33321814
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2020Whole-Genome Sequencing of Bacterial Isolates That Degrade the Cyanobacterial Toxin Microcystin-LR. MICROBIOLOGY RESOURCE ANNOUNCEMENTS. 9.Full Text via DOI: 10.1128/mra.00959-20
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2019Isolation and characterization of Lake Erie bacteria that degrade the cyanobacterial microcystin toxin MC-LR. JOURNAL OF GREAT LAKES RESEARCH. 45:138-149.Full Text via DOI: 10.1016/j.jglr.2018.10.013
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2016FmvB: A Francisella tularensis Magnesium-Responsive Outer Membrane Protein that Plays a Role in Virulence. PLOS ONE. 11.Full Text via DOI: 10.1371/journal.pone.0160977
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2015Revisiting the Gram-Negative Lipoprotein Paradigm. JOURNAL OF BACTERIOLOGY. 197:1705-1715.Full Text via DOI: 10.1128/JB.02414-14
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2015Revisiting the Gram-Negative Lipoprotein Paradigm. JOURNAL OF BACTERIOLOGY. 197:1705-1715.Full Text via DOI: 10.1128/jb.02414-14
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2014Identification of disulfide bond isomerase substrates reveals bacterial virulence factors. MOLECULAR MICROBIOLOGY. 94:926-944.Full Text via DOI: 10.1111/mmi.12808
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2014QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens. MBIO. 5.Full Text via DOI: 10.1128/mBio.02165-14
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2014QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens. MBIO. 5.Full Text via DOI: 10.1128/mbio.02165-14
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2012Identification of a Novel Francisella tularensis Factor Required for Intramacrophage Survival and Subversion of Innate Immune Response. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:25216-25229.Full Text via DOI: 10.1074/jbc.M112.367672
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2012Identification of a Novel Francisella tularensis Factor Required for Intramacrophage Survival and Subversion of Innate Immune Response. JOURNAL OF BIOLOGICAL CHEMISTRY. 287:25216-25229.Full Text via DOI: 10.1074/jbc.m112.367672
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2008Characterization offigoperon mutants ofFrancisella novicidaU112. FEMS Microbiology Letters. 285:270-277.Full Text via DOI: 10.1111/j.1574-6968.2008.01237.x
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2008Native Outer Membrane Proteins Protect Mice against Pulmonary Challenge with Virulent Type A Francisella tularensis. INFECTION AND IMMUNITY. 76:3664-3671.Full Text via DOI: 10.1128/iai.00374-08
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2008Targeting QseC Signaling and Virulence for Antibiotic Development. SCIENCE. 321:1078-1080.Full Text via DOI: 10.1126/science.1160354
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2007Characterization of Francisella tularensis Outer Membrane Proteins. JOURNAL OF BACTERIOLOGY. 189:561-574.Full Text via DOI: 10.1128/jb.01505-06
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2005Comparison of Diagnostic Detection Methods for Mycobacterium avium subsp. paratuberculosis in North American Bison. Veterinary Pathology. 42:42-51.Full Text via DOI: 10.1354/vp.42-1-42
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2005Expression Library Immunization Confers Protection against Mycobacterium avium subsp. paratuberculosis Infection. INFECTION AND IMMUNITY. 73:6877-6884.Full Text via DOI: 10.1128/iai.73.10.6877-6884.2005
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2003The Mycobacterium avium subsp. paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells. MICROBIOLOGY-SGM. 149:2061-2069.Full Text via DOI: 10.1099/mic.0.26323-0
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Conference Poster (Faculty180)
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Lecture or Panel Discussion (Faculty180)
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2020Using Good Bacteria To Protect Us From Bad Cyanobacteria. Biosciences and Biotechnology Division, Lawrence Livermore National Laboratory (LLNL), Department of Energy (DOE); Livermore, California.
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2020Using Good Bacteria to Protect Us From Bad Cyanobacteria. Department of Bioengineering, College of Engineering, University of Toledo; Toledo, Ohio.
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2019Pushing the Envelope: Discovering Virulence Functions for Hypothetical Proteins in Francisella tularensis. Department of Cell Biology and Molecular Genetics, University of Maryland – College Park; College Park, Maryland.
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2019Using Good Bacteria To Protect Us From Bad Cyanobacteria. Stone Lab Summer Lecture Series, Ohio State University Stone Laboratory; Put In Bay, Ohio.
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2018Just Scratching the Surface: The Role of Francisella tularensis Envelope Proteins in Virulence. Department of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences; Little Rock, Arkansas.
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2017Just Scratching the Surface: Changes in the Francisella tularensis Surface Promote Virulence. Department of Microbial Pathogenesis, School of Medicine, University of Maryland – Baltimore; Baltimore, Maryland.
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2017Using Naturally-Occurring Lake Erie Bacteria to Degrade the Microcystin Toxin MC-LR. Harmful Algal Blooms in Lake Erie: 2017 Forecast; Organized by the National Oceanic and Atmospheric Administration (NOAA) and Ohio Sea Grant.
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2016Isolation and Characterization of Lake Erie Bacteria that Degrade the Microcystin Toxin MC-LR. Harmful Algal Blooms (HABs) State of Science Webinar Series (3) – HABs & Safe Drinking Water; Organized by the Great Lakes HABs Collaboratory – Great Lakes Commission.
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2016Just Scratching the Surface: Changes in the Francisella tularensis Surface Promote Virulence. Department of Microbiology, Immunology, and Biochemistry, Regional Biocontainment Laboratory, University of Tennessee Health Science Center; Memphis, Tennessee.
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2016MC-LR Biodegradation Research at the University of Toledo. Microcystin Biodegradation Research Update Webinar; Organized by the United States Geological Survey (USGS).
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2015Hide and Seek: Francisella tularensis Changes Its Surface In Vivo to Promote Virulence. Department of Microbiology and Immunology, Indiana University School of Medicine; Indianapolis, Indiana.
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2014Hide and Seek: In vivo Changes on the Francisella tularensis Surface Promote Virulence. College of Pharmacy and Pharmaceutical Sciences, Seminar Series for Medicinal & Biological Chemistry, University of Toledo; Toledo, Ohio.
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2014Hide and Seek: In vivo Changes on the Francisella tularensis Surface Promote Virulence. Department of Veterinary and Biomedical Science, Pennsylvania State University; University Park, Pennsylvania.
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2013Hide and Seek: In vivo Changes on the Francisella tularensis Surface Promote Virulence. Department of Microbiology and Molecular Genetics, Michigan State University; East Lansing, Michigan.
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2013Hide and Seek: In vivo Changes on the Francisella tularensis Surface Promote Virulence. National Animal Disease Center, Agricultural Research Service (ARS), United States Department of Agriculture (USDA).
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2012Hide and Seek: Changes in Francisella Surface Proteins During Infection Reveal Ideal Vaccine Targets. Department of Microbiology, Miami University; Oxford, Ohio.
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2012Hide and Seek: Changes in Francisella tularensis Surface Proteins During Infection Reveal Ideal Vaccine Targets. Department of Microbiology and Immunology, University of Louisville; Louisville, Kentucky.
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2012Hide and Seek: In vivo Changes in the Francisella tularensis Outer Membrane Promote Virulence. Department of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston; Houston, Texas.
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2012The Great Houdini: How Francisella tularensis Escapes Immune Clearance. Center for Microbial Interface Biology, The Ohio State University; Columbus, Ohio.
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2012The Great Houdini: How Francisella tularensis Escapes Immune Clearance. Department of Immunology and Microbiology, Wayne State University School of Medicine; Detroit, Michigan.
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2012Trick or Treat: Rapid Changes in the Francisella tularensis Outer Membrane Promote Virulence. Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine; Chicago, Illinois.
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2011Francisella tularensis Outer Membranes: Translating Basic Biology into Protective Vaccines. Department of Microbiology and Immunology, University of Illinois at Chicago; Chicago, Illinois.
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2010Francisella tularensis: Translating Basic Research into Vaccines. Department of Biological Sciences, University of Toledo Main Campus.
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Patent (Faculty180)
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Presentation (Faculty180)
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Review Article (Web of Science)
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2020Mechanisms Affecting the Acquisition, Persistence and Transmission of Francisella tularensis in Ticks. MICROORGANISMS.Full Text via DOI: 10.3390/microorganisms8111639 PMID: 33114018
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2019Ticks and Tularemia: Do We Know What We Don't Know?. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.Full Text via DOI: 10.3389/fcimb.2019.00146 PMID: 31139576
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2015From the Outside-In: The Francisella tularensis Envelope and Virulence. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.Full Text via DOI: 10.3389/fcimb.2015.00094
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Contact
full name
- Jason F Huntley