Jasmine JingYuan Liu
Contact Info
Publications
selected publications
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Article (Faculty180)
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2023
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2023eIF3d: a driver of non-canonical cap-dependent translation of specific mRNAs and a trigger of biological/pathological processes. Journal of Biological Chemistry. 104658.
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2022A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. Bioorganic & medicinal chemistry. 65:116761.
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2022Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions. Frontiers in Cell and Developmental Biology. 10:826576.
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2022Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase. Journal of Medicinal Chemistry. 65:13681.
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2022Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation. Journal of Biological Chemistry. 298.
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2021Corrigendum: eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation. Frontiers in Cell and Developmental Biology. 8:629218.
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2021Inhibiting fatty acid synthase with omeprazole to improve efficacy of neoadjuvant chemotherapy in patients with operable TNBC. Clinical Cancer Research. 27:5810.
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2021eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis. Cancer Letters. 500:11.
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2020Synthesis and identification of a novel lead targeting survivin dimerization for proteasome-dependent degradation. Journal of medicinal chemistry. 63:7243.
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2020eIF3a regulation of NHEJ repair protein synthesis and cellular response to ionizing radiation. Frontiers in cell and developmental biology. 8:753.
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2018Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?. Pharmacology & therapeutics. 191:74.
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2017Targeting survivin for therapeutic discovery: past, present, and future promises. Drug discovery today. 22:1466.
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2016Effective targeting of the survivin dimerization interface with small-molecule inhibitors. Cancer research. 76:453.
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2016FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-$kappa$B and SP1. Proceedings of the National Academy of Sciences. 113:E6965.
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2015Integrate omics data and molecular dynamics simulations toward better understanding of human 14-3-3 interactomes and better drugs for cancer therapy. Journal of Genetics and Genomics. 42:531.
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2015Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase. Journal of Medicinal Chemistry. 58:778.
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2014A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion. ACS chemical biology. 9:1188.
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2014Insight into conformational change for 14-3-3$sigma$ protein by molecular dynamics simulation. International Journal of Molecular Sciences. 15:2794.
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2014Mechanism of orlistat hydrolysis by the thioesterase of human fatty acid synthase. ACS catalysis. 4:3444.
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2013Determinants of 14-3-3$sigma$ protein dimerization and function in drug and radiation resistance. Journal of Biological Chemistry. 288:31447.
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2012Biochemistry and pharmacology of human ABCC1/MRP1 and its role in detoxification and in multidrug resistance of cancer chemotherapy. Recent Advances in Cancer Research and Therapy; Elsevier: Amsterdam, The Netherlands. 371.
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2011A new crystal form of mouse thiamin pyrophosphokinase. International journal of biochemistry and molecular biology. 2:111.
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2011Characterization of ligand type of estrogen receptor by MD simulation and mm-PBSA free energy analysis. International journal of biochemistry and molecular biology. 2:190.
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2011Critical residue that promotes protein dimerization: A story of partially exposed Phe25 in 14-3-3$sigma$. Journal of chemical information and modeling. 51:2612.
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2010Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. International journal of biochemistry and molecular biology. 1:69.
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2010Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS chemical biology. 5:953.
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200914-3-3$sigma$, the double-edged sword of human cancers. American journal of translational research. 1:326.
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2006Pyrithiamine as a substrate for thiamine pyrophosphokinase. Journal of Biological Chemistry. 281:6601.
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2003Studies on the Structure and Function of Thiamine Pyrophosphokinase. Thiamine: Catalytic Mechanisms in Normal and Disease States. 29.
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2001Crystal structure of thiamin pyrophosphokinase. Journal of Molecular Biology. 310:195.
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Article (Web of Science)
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2022eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage. ONCOGENE.Full Text via DOI: 10.1038/s41388-022-02262-5 PMID: 35279705
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2021Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase. CANCER LETTERS. 509:1-12.Full Text via DOI: 10.1016/j.canlet.2021.03.026 PMID: 33813001
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2021eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis. CANCER LETTERS. 500:11-20.Full Text via DOI: 10.1016/j.canlet.2020.12.009 PMID: 33301799
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2021Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC. CLINICAL CANCER RESEARCH. 27:5810-5817.Full Text via DOI: 10.1158/1078-0432.ccr-21-0493
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2020eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 8.Full Text via DOI: 10.3389/fcell.2020.00753 PMID: 32974334
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2020Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. JOURNAL OF MEDICINAL CHEMISTRY. 63:7243-7251.Full Text via DOI: 10.1021/acs.jmedchem.0c00475 PMID: 32421328
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2018Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth. ONCOGENE. 37:2469-2480.Full Text via DOI: 10.1038/s41388-017-0076-0
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2016Drugging the “undruggable” DNA-binding domain of STAT3. ONCOTARGET. 7:66324-66325.Full Text via DOI: 10.18632/oncotarget.12181
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2016Effective Targeting of the Survivin Dimerization Interface with Small-Molecule Inhibitors. CANCER RESEARCH. 76:453-462.Full Text via DOI: 10.1158/0008-5472.can-15-1874
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2016FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113:E6965-E6973.Full Text via DOI: 10.1073/pnas.1609934113
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2015Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase. JOURNAL OF MEDICINAL CHEMISTRY. 58:778-784.Full Text via DOI: 10.1021/jm501543u
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2014A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion. ACS CHEMICAL BIOLOGY. 9:1188-1196.Full Text via DOI: 10.1021/cb500071v
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2014Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 15:2794-2810.Full Text via DOI: 10.3390/ijms15022794
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2014Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase. ACS CATALYSIS. 4:3444-3453.Full Text via DOI: 10.1021/cs500956m
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2013Determinants of 14-3-3σ Protein Dimerization and Function in Drug and Radiation Resistance. JOURNAL OF BIOLOGICAL CHEMISTRY. 288:31447-31457.Full Text via DOI: 10.1074/jbc.m113.467753
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2011Critical Residue That Promotes Protein Dimerization: A Story of Partially Exposed Phe25 in 14-3-3σ. Journal of Chemical Information and Modeling. 51:2612-2625.Full Text via DOI: 10.1021/ci200212y
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2010Identification of Novel Small Molecule Inhibitors of the XPA Protein Using in Silico Based Screening. ACS CHEMICAL BIOLOGY. 5:953-965.Full Text via DOI: 10.1021/cb1000444
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Correction (Web of Science)
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2021eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation (vol 8, 753, 2020). FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.Full Text via DOI: 10.3389/fcell.2020.629218 PMID: 33490090
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Dissertation (Faculty180)
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Meeting Abstract (Web of Science)
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Review Article (Web of Science)
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2018Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?. Pharmacology & Therapeutics. 74-91.Full Text via DOI: 10.1016/j.pharmthera.2018.06.006
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2017Targeting survivin for therapeutic discovery: past, present, and future promises. DRUG DISCOVERY TODAY. 1466-1477.Full Text via DOI: 10.1016/j.drudis.2017.05.009
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2015Integrate Omics Data and Molecular Dynamics Simulations toward Better Understanding of Human 14-3-3 Interactomes and Better Drugs for Cancer Therapy. Journal of Genetics and Genomics. 531-547.Full Text via DOI: 10.1016/j.jgg.2015.09.002
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Contact
full name
- Jasmine JingYuan Liu
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Cumulative publications in Scholars@UToledo
