Isaac T Schiefer
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Professor
Director, Center for Drug Design and Development (CD3)
Associate Director, Shimadzu Laboratory for Pharmaceutical Research Excellence, Medicinal and Biological Chemistry , College of Pharmacy and Pharmaceutical Sciences
Publications
selected publications
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Article (Faculty180)
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2023Identifying dual acting small molecule inhibitors for potential treatment of castration-resistant prostate cancer. Results in Chemistry. 6:101058.
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2023Skin penetration of caffeine from commercial eye creams and eye creams designed and optimized based on Hansen solubility parameters. International journal of pharmaceutics. 639:122973.
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2022
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2022Methamphetamine-induced lethal toxicity in zebrafish larvae. Psychopharmacology. 239:3833.
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2021
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2020Combining Neurobehavioral Analysis and Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. ACS chemical neuroscience. 11:2761-2773.
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2020Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. ACS Chemical Neuroscience. 11:2761-2773.
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2019Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents. Nitric oxide : biology and chemistry. 84:69-78.
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2019The Effect of Electronic-Cigarette Vaping on Cardiac Function and Angiogenesis in Mice. Scientific reports. 9:4085.
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2018Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke. Free Radical Biology and Medicine. 115:395.
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2018Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke. Free Radical Biology and Medicine. 115:395.
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2018Furoxans (Oxadiazole-4 N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. Journal of Medicinal Chemistry. 61:4593.
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2018Quantification of phenolic acid metabolites in humans by LC-MS: a structural and targeted metabolomics approach. Bioanalysis. 10:1591-1608.
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2017Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and alpha-7 nicotinic acetylcholine receptor in female CD-1 mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 77:1.
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2017Identification and characterization of 5-alpha-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). The Journal of steroid biochemistry and molecular biology. 174:120.
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2016Human cytosolic sulfotransferase SULT1A3 mediates the sulfation of dextrorphan. Biological & Pharmaceutical Bulletin. 39:1432.
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2016Novel selective calpain 1 inhibitors as potential therapeutics in Alzheimer’s disease. Journal of Alzheimer's Disease. 49:707.
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2014Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. ACS Chemical Neuroscience. 5:823.
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2013Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of medicinal chemistry. 56:6054.
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2012Furoxans (1, 2, 5-Oxadiazole-N-Oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of medicinal chemistry. 55:3076.
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2011Benzothiophene selective estrogen receptor modulators provide neuroprotection by a novel GPR30-dependent mechanism. ACS chemical neuroscience. 2:256.
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2011Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of medicinal chemistry. 54:2293.
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2011NO-SSRIs: nitric oxide chimera drugs incorporating a selective serotonin reuptake inhibitor. ACS Medicinal Chemistry Letters. 2:656.
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2010Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. ACS chemical biology. 5:667.
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Article (Web of Science)
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2021E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. CHEMICO-BIOLOGICAL INTERACTIONS. 333.Full Text via DOI: 10.1016/j.cbi.2020.109308 PMID: 33242460
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2020Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. ACS CHEMICAL NEUROSCIENCE. 11:2761-2773.Full Text via DOI: 10.1021/acschemneuro.0c00416 PMID: 32786314
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2019The Effect of Electronic-Cigarette Vaping on Cardiac Function and Angiogenesis in Mice. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-40847-5
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2019Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 84:69-78.Full Text via DOI: 10.1016/j.niox.2019.01.001
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2018Quantification of phenolic acid metabolites in humans by LC-MS: a structural and targeted metabolomics approach. BIOANALYSIS. 10:1591-1608.Full Text via DOI: 10.4155/bio-2018-0140
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2018Furoxans (Oxadiazole-4N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. JOURNAL OF MEDICINAL CHEMISTRY. 61:4593-4607.Full Text via DOI: 10.1021/acs.jmedchem.8b00389
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2018Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke. FREE RADICAL BIOLOGY AND MEDICINE. 115:395-404.Full Text via DOI: 10.1016/j.freeradbiomed.2017.12.027
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2017Identification and characterization of 5 alpha-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 174:120-127.Full Text via DOI: 10.1016/j.jsbmb.2017.08.005
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2017Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and alpha-7 nicotinic acetylcholine receptor in female CD-1 mice. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 77:1-8.Full Text via DOI: 10.1016/j.pnpbp.2017.03.017
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2016Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 39:1432-1436.
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2016Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 39:1432-1436.Full Text via DOI: 10.1248/bpb.b16-00015
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2015Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease. JOURNAL OF ALZHEIMERS DISEASE. 49:707-721.Full Text via DOI: 10.3233/jad-150618
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2014Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis. ACS CHEMICAL NEUROSCIENCE. 5:823-829.Full Text via DOI: 10.1021/cn500147v
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2013Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY. 56:6054-6068.Full Text via DOI: 10.1021/jm4006719
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2012Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents. JOURNAL OF MEDICINAL CHEMISTRY. 55:3076-3087.Full Text via DOI: 10.1021/jm201504s
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2011Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism. ACS CHEMICAL NEUROSCIENCE. 2:256-268.Full Text via DOI: 10.1021/cn100106a
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2011Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates. JOURNAL OF MEDICINAL CHEMISTRY. 54:2293-2306.Full Text via DOI: 10.1021/jm101450p
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2011NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS. 2:656-661.Full Text via DOI: 10.1021/ml2000033
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2010Proteomic and Mass Spectroscopic Quantitation of Protein S-Nitrosation Differentiates NO-Donors. ACS CHEMICAL BIOLOGY. 5:667-680.Full Text via DOI: 10.1021/cb100054m
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Conference Poster (Faculty180)
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Correction (Web of Science)
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2018Correction to Furoxans (Oxadiazole-N-oxides) with Attenuated Reactivity Are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. JOURNAL OF MEDICINAL CHEMISTRY. 5773-5773.Full Text via DOI: 10.1021/acs.jmedchem.8b00891
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Dissertation (Faculty180)
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Meeting Abstract (Web of Science)
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2021Abstract MP38: Identification Of A Gut Microbe That Attenuates The Blood Pressure Lowering Effect Of ACEi Quinapril. HYPERTENSION.Full Text via DOI: 10.1161/hyp.78.suppl_1.mp38
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2021Depletion of Esterase‐Harboring Bacteria Increases Antihypertensive Efficacy of ACE Inhibitor Quinapril. FASEB JOURNAL. fasebj.2021.35.S1.02954.Full Text via DOI: 10.1096/fasebj.2021.35.s1.02954
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Patent (Faculty180)
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Presentation (Faculty180)
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Proceedings (Faculty180)
Contact
full name
- Isaac T Schiefer
visualizations
Cumulative publications in Scholars@UToledo
