Schiefer, Isaac T

Isaac T Schiefer
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Positions

Associate Professor
Director, Center for Drug Design and Development (CD3)
Associate Director, Shimadzu Laboratory for Pharmaceutical Research Excellence, Medicinal and Biological Chemistry , College of Pharmacy and Pharmaceutical Sciences

Contact Info

isaac.schiefer@UToledo.Edu

http://www.utoledo.edu/pharmacy/depts/mbc/faculty-ischiefer.html

selected publications

Article (Web of Science)
- 2021
  
  E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. CHEMICO-BIOLOGICAL INTERACTIONS. 333.
  Full Text via DOI: 10.1016/j.cbi.2020.109308 PMID: 33242460
- 2020
  
  Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. ACS CHEMICAL NEUROSCIENCE. 11:2761-2773.
  Full Text via DOI: 10.1021/acschemneuro.0c00416 PMID: 32786314
- 2019
  
  The Effect of Electronic-Cigarette Vaping on Cardiac Function and Angiogenesis in Mice. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-019-40847-5
- 2019
  
  Pharmacokinetics and pharmacodynamics of nitric oxide mimetic agents. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 84:69-78.
  Full Text via DOI: 10.1016/j.niox.2019.01.001
- 2018
  
  Quantification of phenolic acid metabolites in humans by LC-MS: a structural and targeted metabolomics approach. BIOANALYSIS. 10:1591-1608.
  Full Text via DOI: 10.4155/bio-2018-0140
- 2018
  
  Furoxans (Oxadiazole-4N-oxides) with Attenuated Reactivity are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. JOURNAL OF MEDICINAL CHEMISTRY. 61:4593-4607.
  Full Text via DOI: 10.1021/acs.jmedchem.8b00389
- 2018
  
  Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke. FREE RADICAL BIOLOGY AND MEDICINE. 115:395-404.
  Full Text via DOI: 10.1016/j.freeradbiomed.2017.12.027
- 2017
  
  Identification and characterization of 5 alpha-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 174:120-127.
  Full Text via DOI: 10.1016/j.jsbmb.2017.08.005
- 2017
  
  Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and alpha-7 nicotinic acetylcholine receptor in female CD-1 mice. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 77:1-8.
  Full Text via DOI: 10.1016/j.pnpbp.2017.03.017
- 2016
  
  Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 39:1432-1436.
- 2016
  
  Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 39:1432-1436.
  Full Text via DOI: 10.1248/bpb.b16-00015
- 2015
  
  Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease. JOURNAL OF ALZHEIMERS DISEASE. 49:707-721.
  Full Text via DOI: 10.3233/jad-150618
- 2014
  
  Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis. ACS CHEMICAL NEUROSCIENCE. 5:823-829.
  Full Text via DOI: 10.1021/cn500147v
- 2013
  
  Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY. 56:6054-6068.
  Full Text via DOI: 10.1021/jm4006719
- 2012
  
  Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents. JOURNAL OF MEDICINAL CHEMISTRY. 55:3076-3087.
  Full Text via DOI: 10.1021/jm201504s
- 2011
  
  Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism. ACS CHEMICAL NEUROSCIENCE. 2:256-268.
  Full Text via DOI: 10.1021/cn100106a
- 2011
  
  Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates. JOURNAL OF MEDICINAL CHEMISTRY. 54:2293-2306.
  Full Text via DOI: 10.1021/jm101450p
- 2011
  
  NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS. 2:656-661.
  Full Text via DOI: 10.1021/ml2000033
- 2010
  
  Proteomic and Mass Spectroscopic Quantitation of Protein S-Nitrosation Differentiates NO-Donors. ACS CHEMICAL BIOLOGY. 5:667-680.
  Full Text via DOI: 10.1021/cb100054m
Correction (Web of Science)
- 2018
  
  Correction to Furoxans (Oxadiazole-N-oxides) with Attenuated Reactivity Are Neuroprotective, Cross the Blood Brain Barrier, and Improve Passive Avoidance Memory. JOURNAL OF MEDICINAL CHEMISTRY. 5773-5773.
  Full Text via DOI: 10.1021/acs.jmedchem.8b00891
Meeting Abstract (Web of Science)
- 2021
  
  Abstract MP38: Identification Of A Gut Microbe That Attenuates The Blood Pressure Lowering Effect Of ACEi Quinapril. HYPERTENSION.
  Full Text via DOI: 10.1161/hyp.78.suppl_1.mp38
- 2021
  
  Depletion of Esterase‐Harboring Bacteria Increases Antihypertensive Efficacy of ACE Inhibitor Quinapril. FASEB JOURNAL. fasebj.2021.35.S1.02954.
  Full Text via DOI: 10.1096/fasebj.2021.35.s1.02954

full name

Isaac T Schiefer

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