Williams, Frederick E

Frederick E Williams
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Positions

Professor
Chair, Pharmacology , College of Pharmacy and Pharmaceutical Sciences

Contact Info

FREDERICK.WILLIAMS2@utoledo.edu

selected publications

Article (Faculty180)
- 2020
  
  Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. ACS Chemical Neuroscience. 11:2761-2773.
- 2019
  
  Developmental effects of trichloroacetate in Zebrafish embryos: Association with the production of superoxide anion. J Biochem Mol Toxicol. 33.
- 2019
  
  Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase. J Steroid Biochem Mol Biol. 185:110-117.
- 2019
  
  Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells. Cancers . 23.
- 2019
  
  The GSK3β inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer's disease. Neurochem Int. 122:31-37.
- 2018
  
  Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish. Front Pharmacol. 9:340.
- 2018
  
  Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease. Neurochem Int. 115:61-68.
- 2018
  
  Utilizing zebrafish and okadaic acid to study Alzheimer's disease.. Neural Regen Res. 13:1538-1541.
- 2017
  
  HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies. Frontiers in Pharmacology. 8:498.
- 2017
  
  Identification and characterization of 5Î±-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). Journal of Steroid Biochemistry and Molecular Biology. august:005.
- 2016
  
  Development of a Novel and Robust Pharmacological Model of Okadaic Acid-induced Alzheimer's Disease in Zebrafish. Cns & Neurological Disorders-Drug Targets. 15:86-94.
- 2015
  
  Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. Journal of Applied Toxicology. 36:1090-1094.
- 2014
  
  Primary Cilium Regulates CaV1.2 Expression Through Wnt Signaling. Journal of Cellular Physiology. 229:1926-1934.
- 2013
  
  Development and Characterization of Nanostructured Mists with Potential for Actively Targeting Poorly Water-Soluble Compounds into the Lungs. Pharmaceutical Research. 30:2625-2639.
- 2013
  
  Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications. Drug Development and Industrial Pharmacy. 39:240-251.
- 2012
  
  Ethanol Sulfation by the Human Cytosolic Sulfotransferases: A Systematic Analysis. Biological & Pharmaceutical Bulletin. 35:2180-2185.
- 2012
  
  Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5. Aquatic Toxicology. 112:11-18.
- 2011
  
  A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs). Journal of Steroid Biochemistry and Molecular Biology. 127:307-314.
- 2011
  
  Developmental toxicity of dextromethorphan in zebrafish embryos/larvae. Journal of Applied Toxicology. 31:157-163.
- 2011
  
  Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish. Aquatic Toxicology. 102:18-23.
- 2011
  
  Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. Neuropharmacology. 61:12-24.
- 2010
  
  A comparative study of embedded and anesthetized zebrafish in vivo on myocardiac calcium oscillation and heart muscle contraction. Frontiers in Pharmacology. 1:139.
- 2010
  
  Developmental selenomethionine and methylmercury exposures affect zebrafish learning. Neurotoxicology and Teratology. 32:246-255.
- 2010
  
  Sulfation of drug compounds by the zebrafish cytosolic sulfotransferases (SULTS). Drug Metabolism Letters. 4:62-68.
- 2010
  
  Zebrafish as a Model for the Study of the Phase II Cytosolic Sulfotransferases. Current Drug Metabolism. 11:538-546.
- 2009
  
  A novel hydroxysteroid-sulfating cytosolic sulfotransferase, SULT3 ST3, from zebrafish: Identification, characterization, and ontogenic study. Drug Metabolism Letters. 3:217-227.
- 2009
  
  A target-specific approach for the identification of tyrosine-sulfated hemostatic proteins. Analytical Biochemistry. 390:88-90.
- 2009
  
  Zebrafish as a model to study cardiovascular functions. Faseb Journal. 23:939.
- 2008
  
  Characterization and ontogenic study of novel steroid-sulfating SULT3 sulfotransferases from zebrafish. Molecular and Cellular Endocrinology. 294:29-36.
- 2008
  
  Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish. Aquatic Toxicology. 89:94-102.
- 2006
  
  Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio). Journal of Biochemical and Molecular Toxicology. 20:183-190.
- 2005
  
  Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos. Journal of Biochemical and Molecular Toxicology. 19:52-58.
- 2004
  
  Ethanol effects on the developing zebrafish: Neurobehavior and skeletal morphogenesis. Neurotoxicology and Teratology. 26:757-768.
- 2004
  
  Muscarinic acetylcholine receptors in the brain of the zebrafish (Danio rerio) measured by radioligand binding techniques. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 137:349-53.
- 2002
  
  A simple spatial alternation task for assessing memory function in zebrafish. Behavioural Processes. 58:125-132.
- 2000
  
  Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: Characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors. Pharmaceutica Acta Helvetiae. 74:135-140.
- 1999
  
  Differential modulation of agonist potency and receptor coupling by mutations of Ser388Tyr and Thr389Pro at the junction of transmembrane domain VI and the third extracellular loop of human M1 muscarinic acetylcholine receptors. Molecular Pharmacology. 56:775-783.
- 1999
  
  Mutant M 1 muscarinic receptors with enhanced agonist activity. Life Sciences. 64:563.
- 1999
  
  Mutant M-1 muscarinic receptors with increased agonist affinity and G protein coupling. Life Sciences. 64:563-563.
- 1999
  
  Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M1 muscarinic receptors. British Journal of Pharmacology. 126:735-745.
- 1998
  
  Pharmacological characterization of human m1 muscarinic acetylcholine receptors with double mutations at the junction of TM VI and the third extracellular domain. Journal of Pharmacology and Experimental Therapeutics. 286:1129-1139.
- 1997
  
  Insulin and the gastrointestinal tract. Journal of Controlled Release. 46:89-98.
- 1996
  
  Insulin in the drinking water of rats. Drug Delivery. 3:81-85.
- 1993
  
  Transformation of an L-cell line with the DNA coding for the reduced- folate/methotrexate transporter protein from a CCRF-CEM human leukemia cell line. Advances in Experimental Medicine and Biology. 338:779-782.
- 1992
  
  Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines. Advances in enzyme regulation. 32:17-31.
- 1991
  
  The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Molecular and Cellular Biology. 11:3307-3316.
- 1990
  
  Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae. Molecular and Cellular Biology. 10:6500-6511.
- 1986
  
  A new approach to the oral administration of insulin and other peptide drugs. Science. 233:1081-1085.
Article (Web of Science)
- 2020
  
  Combining Neurobehavioral Analysis and In Vivo Photoaffinity Labeling to Understand Protein Targets of Methamphetamine in Casper Zebrafish. ACS CHEMICAL NEUROSCIENCE. 11:2761-2773.
  Full Text via DOI: 10.1021/acschemneuro.0c00416 PMID: 32786314
- 2019
  
  Novel Thienopyrimidine Derivative, RP-010, Induces beta-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells. CANCERS. 11.
  Full Text via DOI: 10.3390/cancers11050711 PMID: 31126091
- 2019
  
  Developmental effects of trichloroacetate in Zebrafish embryos: Association with the production of superoxide anion. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 33.
  Full Text via DOI: 10.1002/jbt.22259
- 2019
  
  Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 185:110-117.
  Full Text via DOI: 10.1016/j.jsbmb.2018.08.004
- 2019
  
  The GSK3 beta inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer's disease. NEUROCHEMISTRY INTERNATIONAL. 122:31-37.
  Full Text via DOI: 10.1016/j.neuint.2018.10.022
- 2018
  
  Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease. NEUROCHEMISTRY INTERNATIONAL. 115:61-68.
  Full Text via DOI: 10.1016/j.neuint.2018.02.002
- 2018
  
  Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish. FRONTIERS IN PHARMACOLOGY. 9.
  Full Text via DOI: 10.3389/fphar.2018.00340
- 2017
  
  Identification and characterization of 5 alpha-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 174:120-127.
  Full Text via DOI: 10.1016/j.jsbmb.2017.08.005
- 2017
  
  HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies. FRONTIERS IN PHARMACOLOGY. 8.
  Full Text via DOI: 10.3389/fphar.2017.00498
- 2016
  
  Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. JOURNAL OF APPLIED TOXICOLOGY. 36:1090-1094.
  Full Text via DOI: 10.1002/jat.3268
- 2016
  
  Development of a Novel and Robust Pharmacological Model of Okadaic Acid-induced Alzheimer's Disease in Zebrafish. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. 15:86-94.
  Full Text via DOI: 10.2174/1871527314666150821105602
- 2014
  
  Primary Cilium Regulates CaV1.2 Expression Through Wnt Signaling. JOURNAL OF CELLULAR PHYSIOLOGY. 229:1926-1934.
  Full Text via DOI: 10.1002/jcp.24642
- 2013
  
  Development and Characterization of Nanostructured Mists with Potential for Actively Targeting Poorly Water-Soluble Compounds into the Lungs. PHARMACEUTICAL RESEARCH. 30:2625-2639.
  Full Text via DOI: 10.1007/s11095-013-1088-2
- 2013
  
  Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 39:240-251.
  Full Text via DOI: 10.3109/03639045.2012.671830
- 2012
  
  Ethanol Sulfation by the Human Cytosolic Sulfotransferases: A Systematic Analysis. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 35:2180-2185.
- 2012
  
  Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5. AQUATIC TOXICOLOGY. 112:11-18.
  Full Text via DOI: 10.1016/j.aquatox.2012.01.015
- 2012
  
  Ethanol Sulfation by the Human Cytosolic Sulfotransferases: A Systematic Analysis. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 35:2180-2185.
  Full Text via DOI: 10.1248/bpb.b12-00547
- 2011
  
  A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 127:307-314.
  Full Text via DOI: 10.1016/j.jsbmb.2011.07.011
- 2011
  
  Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. NEUROPHARMACOLOGY. 61:12-24.
  Full Text via DOI: 10.1016/j.neuropharm.2011.02.010
- 2011
  
  Developmental toxicity of dextromethorphan in zebrafish embryos/larvae. JOURNAL OF APPLIED TOXICOLOGY. 31:157-163.
  Full Text via DOI: 10.1002/jat.1576
- 2011
  
  Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish. AQUATIC TOXICOLOGY. 102:18-23.
  Full Text via DOI: 10.1016/j.aquatox.2010.12.016
- 2010
  
  Developmental selenomethionine and methylmercury exposures affect zebrafish learning. NEUROTOXICOLOGY AND TERATOLOGY. 32:246-255.
  Full Text via DOI: 10.1016/j.ntt.2009.09.004
- 2010
  
  A comparative study of embedded and anesthetized zebrafish in vivo on myocardiac calcium oscillation and heart muscle contraction. FRONTIERS IN PHARMACOLOGY. 1.
  Full Text via DOI: 10.3389/fphar.2010.00139
- 2010
  
  Zebrafish as a Model for the Study of the Phase II Cytosolic Sulfotransferases. CURRENT DRUG METABOLISM. 11:538-546.
  Full Text via DOI: 10.2174/138920010791636158
- 2008
  
  Characterization and ontogenic study of novel steroid-sulfating SULT3 sulfotransferases from zebrafish. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 294:29-36.
  Full Text via DOI: 10.1016/j.mce.2008.06.014
- 2008
  
  Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish. AQUATIC TOXICOLOGY. 89:94-102.
  Full Text via DOI: 10.1016/j.aquatox.2008.06.005
- 2006
  
  Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio). JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 20:183-190.
  Full Text via DOI: 10.1002/jbt.20135
- 2005
  
  Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 19:52-58.
  Full Text via DOI: 10.1002/jbt.20051
Conference Poster (Faculty180)
Editorial Material (Web of Science)
- 2009
  
  A target-specific approach for the identification of tyrosine-sulfated hemostatic proteins. ANALYTICAL BIOCHEMISTRY. 88-90.
  Full Text via DOI: 10.1016/j.ab.2009.04.002
Meeting Abstract (Web of Science)
- 2009
  
  Zebrafish as a model to study cardiovascular functions. FASEB JOURNAL.
Presentation (Faculty180)
- 2023
  
  The lethal toxicity of 3,4-methylenedioxymethamphetamine (MDMA) and methylone in combination with alcohol or nicotine
Review Article (Web of Science)
- 2018
  
  Utilizing zebrafish and okadaic acid to study Alzheimer's disease. NEURAL REGENERATION RESEARCH. 1538-1541.
  Full Text via DOI: 10.4103/1673-5374.237111
- 2010
  
  Zebrafish as a Model for the Study of the Phase II Cytosolic Sulfotransferases. CURRENT DRUG METABOLISM. 538-546.

full name

Frederick E Williams

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