Dong, Fan

Fan Dong
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Positions

Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

fan.dong@utoledo.edu

selected publications

Article (Faculty180)
- 2020
  
  Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation. Scientific reports. 10:17115.
- 2019
  
  Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis. Scientific Reports. 9:737.
- 2017
  
  A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA. J Biol Chem. 292:3496.
- 2015
  
  Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.. J Biol Chem. 290:24561.
- 2013
  
  GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis. PLoS One. 8:e73542.
- 2012
  
  Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation. Int J Hematol. 95:640.
- 2010
  
  A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A.. Oncogene. 29:2843.
- 2009
  
  Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. Proc Natl Acad Sci U S A. 106:1433.
- 2006
  
  Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. J Biol Chem. 281:10745.
- 2006
  
  Involvement of protein kinase Cepsilon in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor. J Immuno. 176:2407.
- 2005
  
  The G-CSF receptor carboxyl terminus, truncated in AML/SCN, is required for induction of a Stat5 protease activity. Leuk Res. 29:1153.
- 2005
  
  Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1. J Leukoc Biol. 78:1008.
Article (Web of Science)
- 2020
  
  Gfi1 upregulates c-Myc expression and promotes c-Myc-driven cell proliferation. SCIENTIFIC REPORTS. 10.
  Full Text via DOI: 10.1038/s41598-020-74278-4 PMID: 33051558
- 2019
  
  Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis. SCIENTIFIC REPORTS. 9.
  Full Text via DOI: 10.1038/s41598-018-37402-z
- 2019
  
  Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation. BLOOD. 134:3769-3769.
  Full Text via DOI: 10.1182/blood-2019-124833
- 2017
  
  A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA. JOURNAL OF BIOLOGICAL CHEMISTRY. 292:3496-3505.
  Full Text via DOI: 10.1074/jbc.M116.755157
- 2017
  
  A Truncated Granulocyte Colony-stimulating Factor Receptor (G-CSFR) Inhibits Apoptosis Induced by Neutrophil Elastase G185R Mutant: IMPLICATION FOR UNDERSTANDING CSF3R GENE MUTATIONS IN SEVERE CONGENITAL NEUTROPENIA. JOURNAL OF BIOLOGICAL CHEMISTRY. 292:3496-3505.
  Full Text via DOI: 10.1074/jbc.m116.755157
- 2015
  
  Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Mon ocyte Development in Response to G-CSF and M-CSF. JOURNAL OF BIOLOGICAL CHEMISTRY. 290:24561-24573.
  Full Text via DOI: 10.1074/jbc.M115.668871
- 2015
  
  Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Monocyte Development in Response to G-CSF and M-CSF. JOURNAL OF BIOLOGICAL CHEMISTRY. 290:24561-24573.
  Full Text via DOI: 10.1074/jbc.m115.668871
- 2013
  
  GFI1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis. PLOS ONE. 8.
  Full Text via DOI: 10.1371/journal.pone.0073542
- 2012
  
  Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation. INTERNATIONAL JOURNAL OF HEMATOLOGY. 95:640-647.
  Full Text via DOI: 10.1007/s12185-012-1078-x
- 2012
  
  Gfi1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis. BLOOD. 120:1228-1228.
  Full Text via DOI: 10.1182/blood.v120.21.1228.1228
- 2010
  
  A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A. ONCOGENE. 29:2843-2852.
  Full Text via DOI: 10.1038/onc.2010.48
- 2009
  
  Gfi-1 represses CDKN2B encoding p15(INK4B) through interaction with Miz-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106:1433-1438.
  Full Text via DOI: 10.1073/pnas.0804863106
- 2006
  
  Increased CCAAT Enhancer-binding Protein ϵ (C/EBPϵ) Expression and Premature Apoptosis in Myeloid Cells Expressing Gfi-1 N382S Mutant Associated with Severe Congenital Neutropenia. JOURNAL OF BIOLOGICAL CHEMISTRY. 281:10745-10751.
  Full Text via DOI: 10.1074/jbc.m510924200
- 2006
  
  Involvement of Protein Kinase Cε in the Negative Regulation of Akt Activation Stimulated by Granulocyte Colony-Stimulating Factor. JOURNAL OF IMMUNOLOGY. 176:2407-2413.
  Full Text via DOI: 10.4049/jimmunol.176.4.2407
- 2005
  
  The G-CSF receptor carboxyl terminus, truncated in AML/SCN, is required for induction of a Stat5 protease activity. Leukemia Research. 29:1153-1162.
  Full Text via DOI: 10.1016/j.leukres.2005.03.005
- 2005
  
  Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1. JOURNAL OF LEUKOCYTE BIOLOGY. 78:1008-1015.
  Full Text via DOI: 10.1189/jlb.0105032
Conference Poster (Faculty180)
- 2019
  
  Gfi1 Upregulates c-Myc Expression and Promotes c-Myc-Driven Cell Proliferation
- 2017
  
  Gfi1-Mediated Repression of c-Fos, Egr1 and Egr2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis
Lecture or Panel Discussion (Faculty180)
- 2018
  
  Erk1/2 Signaling in Regulation of Neutrophil vs Monocyte Development: Implication for Understanding How G-CSF and Gfi1 Promote Granulopoiesis. Invited talk, Department of Hematology, Nantong University, China.
Meeting Abstract (Web of Science)
- 2014
  
  The Duration of Erk1/2 Signaling Determines Neutrophil Versus Monocyte Cell Fates in Response to G-CSF and M-CSF. BLOOD.
- 2012
  
  Gfi1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis. BLOOD.
- 2008
  
  Gfi-1 Represses CDKJV2B Encoding p15(INK4B) through Interaction with MiZ-1. BLOOD. 1224-1224.
- 2006
  
  Functional Gfi-1 is important for BCR/ABL-mediated proliferation and survival of myeloid cells.. BLOOD. 286B-286B.
- 2006
  
  The C-terminal region of the G-CSF receptor is required for induction of neutrophil elastase expression in myeloid cells: Implication for understanding CSF3R mutations in acute myeloid leukemia evolving from severe congenital neutropenia.. BLOOD. 342A-342A.
- 2005
  
  Expression of C/EBP epsilon restores G-CSF-Induced granulocytic differentiation of myeloid cells expressing the carboxy truncated G-CSF receptor associated with AML/SCN.. BLOOD. 881A-881A.
- 2005
  
  Gfi-1 represses C/EBPe and is required for the survival and proliferation of myeloid cells stimulated by G-CSF.. BLOOD. 881A-881A.
- 2004
  
  A Serine Protease Activity Is Induced by G-CSF and Degrades Stat5 Proteins in Myeloid Cells.. BLOOD. 2180-2180.
  Full Text via DOI: 10.1182/blood.v104.11.2180.2180
- 2004
  
  Involvement of PKCe in the Negative Regulation of Akt Activation Stimulated by G-CSF.. BLOOD. 2187-2187.
  Full Text via DOI: 10.1182/blood.v104.11.2187.2187
Presentation (Faculty180)
- 2024
  
  Miz-1 Interaction and Upregulation of c-Myc as Potential Mechanisms of Functional Collaboration between Gfi1 and Myc in Lymphomagenesis

full name

Fan Dong

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