Deborah J Vestal
- Associate Professor, Biological Sciences , College of Natural Sciences and Mathematics
Contact Info
Publications
selected publications
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Article (Faculty180)
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2021
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2016Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. Biochemical and Biophysical Research Communications. 478:1617.
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2016hGBP-1 Expression Predicts Shorter Progression-Free Survival in Ovarian Cancers, While Contributing to Paclitaxel Resistance. Journal of cancer therapy. 7:994.
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2011Role of GTP binding, isoprenylation, and the C-terminal alpha-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2. Journal of Interferon & Cytokine Research. 31:291.
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2011The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. Journal of Interferon & Cytokine Research. 31:89.
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2011The interferon-gamma-induced GTPase, mGBP-2, inhibits TNF-alpha-induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac.. Journal of Biological Chemistry. jbc.
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2006In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Journal of Interferon & Cytokine Research. 26:328.
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2006The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.. Cellular and Molecular Biology (Noisy-le-Grand, France). 52:43.
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2005
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2005The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. Journal of Interferon & Cytokine Research. 25:435.
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2002The interferon (IFN)-induced gtpase, mGBP-2 role in IFN-gamma-induced murine fibroblast proliferation. Journal of Biological Chemistry. 277:6080.
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2000Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?. Journal of Interferon & Cytokine Research. 20:991.
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1999DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. Journal of Biological Chemistry. 274:20432.
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1998Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages. Journal of Interferon & Cytokine Research. 18:977.
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1996Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate-binding protein, huGBP1. Journal of Leukocyte Biology. 60:423.
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1996Rat p67 GBP is induced by interferon-gamma and isoprenoid-modified in macrophages. Biochemical and Biophysical Research Communications. 224:528.
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1996Targeted disruption of the PU. 1 gene results in multiple hematopoietic abnormalities.. The EMBO journal. 15:5647.
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1995Induction of a prenylated 65-kd protein in macrophages by interferon or lipopolysaccharide. Journal of Leukocyte Biology. 58:607.
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1993T-Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T-cadherin and N-cadherin. Journal of Neuroscience Research. 34:664.
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1992Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.. The Journal of Cell Biology. 119:451.
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1990Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.. Journal of Biological Chemistry. 265:11008.
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1990cDNA sequence of the human integrin beta 5 subunit.. Journal of Biological Chemistry. 265:17126.
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Article (Web of Science)
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2016Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 478:1617-1623.Full Text via DOI: 10.1016/j.bbrc.2016.08.169
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2011The Interferon-gamma-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor alpha(TNF-alpha) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-kappa B and Rac Protein. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:20054-20064.Full Text via DOI: 10.1074/jbc.M111.249326
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2011Role of GTP Binding, Isoprenylation, and the C-Terminal alpha-Helices in the Inhibition of Cell Spreading by the Interferon-Induced GTPase, Mouse Guanylate-Binding Protein-2. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 31:291-298.Full Text via DOI: 10.1089/jir.2010.0056
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2011The Interferon-γ-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor α (TNF-α) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-κB and Rac Protein. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:20054-20064.Full Text via DOI: 10.1074/jbc.m111.249326
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2010The Interferon-gamma-induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase. MOLECULAR BIOLOGY OF THE CELL. 21:2514-2528.Full Text via DOI: 10.1091/mbc.E09-04-0344
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2010The Interferon-γ–induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase. MOLECULAR BIOLOGY OF THE CELL. 21:2514-2528.Full Text via DOI: 10.1091/mbc.e09-04-0344
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2006In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 26:328-352.
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2006The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation. CELLULAR AND MOLECULAR BIOLOGY. 52:43-49.Full Text via DOI: 10.1170/T696
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2006In SilicoGenomic Analysis of the Human and Murine Guanylate-Binding Protein (GBP) Gene Clusters. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 26:328-352.Full Text via DOI: 10.1089/jir.2006.26.328
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2005Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. ARCHIVES OF VIROLOGY. 150:1213-1220.Full Text via DOI: 10.1007/s00705-004-0489-2
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2002The Interferon (IFN)-induced GTPase, mGBP-2. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:6080-6087.Full Text via DOI: 10.1074/jbc.m110542200
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2000Different Subcellular Localizations for the Related Interferon-Induced GTPases, MuGBP-1 and MuGBP-2: Implications for Different Functions?. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 20:991-1000.Full Text via DOI: 10.1089/10799900050198435
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1999DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:20432-20437.Full Text via DOI: 10.1074/jbc.274.29.20432
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1998Murine GBP-2: A New IFN-γ-Induced Member of the GBP Family of GTPases Isolated from Macrophages. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 18:977-985.Full Text via DOI: 10.1089/jir.1998.18.977
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1996Prenylation of an interferon-γ-induced GTP-binding protein: the human guanylate binding protein, huGBP1. JOURNAL OF LEUKOCYTE BIOLOGY. 60:423-431.Full Text via DOI: 10.1002/jlb.60.3.423
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1996Rat p67 GBP Is Induced by Interferon-γ and Isoprenoid-Modified in Macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 224:528-534.Full Text via DOI: 10.1006/bbrc.1996.1060
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1996Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.. EMBO JOURNAL. 15:5647-5658.Full Text via DOI: 10.1002/j.1460-2075.1996.tb00949.x
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1995Induction of a prenylated 65-kd protein in macrophages by interferon or lipopolysaccharide. JOURNAL OF LEUKOCYTE BIOLOGY. 58:607-615.Full Text via DOI: 10.1002/jlb.58.5.607
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1993T-Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T-cadherin and N-cadherin. JOURNAL OF NEUROSCIENCE RESEARCH. 34:664-680.Full Text via DOI: 10.1002/jnr.490340610
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1992Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.. JOURNAL OF CELL BIOLOGY. 119:451-461.Full Text via DOI: 10.1083/jcb.119.2.451
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1990A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 276:278-284.Full Text via DOI: 10.1016/0003-9861(90)90039-2
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Conference Poster (Faculty180)
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Meeting Abstract (Web of Science)
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2015Guanylate-Binding Proteins (GBPs): Large cytokine-induced GTPases that regulate the cytoskeleton. CYTOKINE. 103-103.Full Text via DOI: 10.1016/j.cyto.2015.08.216
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2010The IFN-induced large GTPase, mGBP-2, inhibits Rac activation initiated by integrin engagement or treatment with either PDGF or TNF-alpha. CYTOKINE. 14-14.Full Text via DOI: 10.1016/j.cyto.2010.07.062
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2009The IFN-induced gtpase, MGBP-2, inhibits TNF-alpha induction of matrix metalloproteinase-9 (MMP-9) by inhibiting activation of NF-kappa B and RAC 1. CYTOKINE. 122-122.Full Text via DOI: 10.1016/j.cyto.2009.07.514
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2008MGBP-2 inhibits RAC activation by platelet-derived growth factor or integrin engagement: Possible role of phosphatidylinositol 3-kinase. CYTOKINE. 328-328.Full Text via DOI: 10.1016/j.cyto.2008.07.442
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2007The pro-inflammatory cytokine-induced GTPase, mGBP-2, inhibits RAC activation by both PDGF treatment and cell spreading. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 718-718.
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2006
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Proceedings (Faculty180)
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Review Article (Web of Science)
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2011The Guanylate-Binding Proteins: Emerging Insights into the Biochemical Properties and Functions of This Family of Large Interferon-Induced Guanosine Triphosphatase. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 89-97.Full Text via DOI: 10.1089/jir.2010.0102
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2005The guanylate-binding proteins (GBPs): Proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 435-443.
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2005Review:The Guanylate-Binding Proteins (GBPs): Proinflammatory Cytokine-Induced Members of the Dynamin Superfamily with Unique GTPase Activity. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 435-443.Full Text via DOI: 10.1089/jir.2005.25.435
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Contact
full name
- Deborah J Vestal
visualizations
Cumulative publications in Scholars@UToledo