Vestal, Deborah J

Deborah J Vestal
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Positions

Associate Professor, Biological Sciences , College of Natural Sciences and Mathematics

Contact Info

Deborah.Vestal@utoledo.edu

selected publications

Article (Faculty180)
- 2016
  
  Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. Biochemical and Biophysical Research Communications. 478:1617.
- 2016
  
  hGBP-1 Expression Predicts Shorter Progression-Free Survival in Ovarian Cancers, While Contributing to Paclitaxel Resistance. Journal of cancer therapy. 7:994.
- 2011
  
  Role of GTP binding, isoprenylation, and the C-terminal alpha-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2. Journal of Interferon & Cytokine Research. 31:291.
- 2011
  
  The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. Journal of Interferon & Cytokine Research. 31:89.
- 2011
  
  The interferon-gamma-induced GTPase, mGBP-2, inhibits TNF-alpha-induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac.. Journal of Biological Chemistry. jbc.
- 2010
  
  A Highlights from MBoC Selection: The Interferon-gamma--induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase. Molecular Biology of the Cell. 21:2514.
- 2010
  
  The Interferon-gamma--induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase. Molecular Biology of the Cell. 21:2514.
- 2006
  
  In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Journal of Interferon & Cytokine Research. 26:328.
- 2006
  
  The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.. Cellular and Molecular Biology (Noisy-le-Grand, France). 52:43.
- 2005
  
  Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. Archives of Virology. 150:1213.
- 2005
  
  The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. Journal of Interferon & Cytokine Research. 25:435.
- 2002
  
  The interferon (IFN)-induced gtpase, mGBP-2 role in IFN-gamma-induced murine fibroblast proliferation. Journal of Biological Chemistry. 277:6080.
- 2000
  
  Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?. Journal of Interferon & Cytokine Research. 20:991.
- 1999
  
  DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. Journal of Biological Chemistry. 274:20432.
- 1998
  
  Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages. Journal of Interferon & Cytokine Research. 18:977.
- 1996
  
  Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate-binding protein, huGBP1. Journal of Leukocyte Biology. 60:423.
- 1996
  
  Rat p67 GBP is induced by interferon-gamma and isoprenoid-modified in macrophages. Biochemical and Biophysical Research Communications. 224:528.
- 1996
  
  Targeted disruption of the PU. 1 gene results in multiple hematopoietic abnormalities.. The EMBO journal. 15:5647.
- 1995
  
  Induction of a prenylated 65-kd protein in macrophages by interferon or lipopolysaccharide. Journal of Leukocyte Biology. 58:607.
- 1993
  
  T-Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T-cadherin and N-cadherin. Journal of Neuroscience Research. 34:664.
- 1992
  
  Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.. The Journal of Cell Biology. 119:451.
- 1990
  
  A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 Cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis. Arch Biochem Biophys. 278:278-284.
- 1990
  
  Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.. Journal of Biological Chemistry. 265:11008.
- 1990
  
  cDNA sequence of the human integrin beta 5 subunit.. Journal of Biological Chemistry. 265:17126.
Article (Web of Science)
- 2016
  
  Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 478:1617-1623.
  Full Text via DOI: 10.1016/j.bbrc.2016.08.169
- 2011
  
  The Interferon-gamma-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor alpha(TNF-alpha) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-kappa B and Rac Protein. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:20054-20064.
  Full Text via DOI: 10.1074/jbc.M111.249326
- 2011
  
  Role of GTP Binding, Isoprenylation, and the C-Terminal alpha-Helices in the Inhibition of Cell Spreading by the Interferon-Induced GTPase, Mouse Guanylate-Binding Protein-2. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 31:291-298.
  Full Text via DOI: 10.1089/jir.2010.0056
- 2011
  
  The Interferon-γ-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor α (TNF-α) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-κB and Rac Protein. JOURNAL OF BIOLOGICAL CHEMISTRY. 286:20054-20064.
  Full Text via DOI: 10.1074/jbc.m111.249326
- 2010
  
  The Interferon-gamma-induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase. MOLECULAR BIOLOGY OF THE CELL. 21:2514-2528.
  Full Text via DOI: 10.1091/mbc.E09-04-0344
- 2010
  
  The Interferon-γ–induced Murine Guanylate-Binding Protein-2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3-Kinase. MOLECULAR BIOLOGY OF THE CELL. 21:2514-2528.
  Full Text via DOI: 10.1091/mbc.e09-04-0344
- 2006
  
  In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 26:328-352.
- 2006
  
  The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation. CELLULAR AND MOLECULAR BIOLOGY. 52:43-49.
  Full Text via DOI: 10.1170/T696
- 2006
  
  In SilicoGenomic Analysis of the Human and Murine Guanylate-Binding Protein (GBP) Gene Clusters. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 26:328-352.
  Full Text via DOI: 10.1089/jir.2006.26.328
- 2005
  
  Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. ARCHIVES OF VIROLOGY. 150:1213-1220.
  Full Text via DOI: 10.1007/s00705-004-0489-2
- 2002
  
  The Interferon (IFN)-induced GTPase, mGBP-2. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:6080-6087.
  Full Text via DOI: 10.1074/jbc.m110542200
- 2000
  
  Different Subcellular Localizations for the Related Interferon-Induced GTPases, MuGBP-1 and MuGBP-2: Implications for Different Functions?. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 20:991-1000.
  Full Text via DOI: 10.1089/10799900050198435
- 1999
  
  DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:20432-20437.
  Full Text via DOI: 10.1074/jbc.274.29.20432
- 1998
  
  Murine GBP-2: A New IFN-γ-Induced Member of the GBP Family of GTPases Isolated from Macrophages. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 18:977-985.
  Full Text via DOI: 10.1089/jir.1998.18.977
- 1996
  
  Prenylation of an interferon-γ-induced GTP-binding protein: the human guanylate binding protein, huGBP1. JOURNAL OF LEUKOCYTE BIOLOGY. 60:423-431.
  Full Text via DOI: 10.1002/jlb.60.3.423
- 1996
  
  Rat p67 GBP Is Induced by Interferon-γ and Isoprenoid-Modified in Macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 224:528-534.
  Full Text via DOI: 10.1006/bbrc.1996.1060
- 1996
  
  Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.. EMBO JOURNAL. 15:5647-5658.
  Full Text via DOI: 10.1002/j.1460-2075.1996.tb00949.x
- 1995
  
  Induction of a prenylated 65-kd protein in macrophages by interferon or lipopolysaccharide. JOURNAL OF LEUKOCYTE BIOLOGY. 58:607-615.
  Full Text via DOI: 10.1002/jlb.58.5.607
- 1993
  
  T-Cadherin 2: Molecular characterization, function in cell adhesion, and coexpression with T-cadherin and N-cadherin. JOURNAL OF NEUROSCIENCE RESEARCH. 34:664-680.
  Full Text via DOI: 10.1002/jnr.490340610
- 1992
  
  Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.. JOURNAL OF CELL BIOLOGY. 119:451-461.
  Full Text via DOI: 10.1083/jcb.119.2.451
- 1990
  
  A rapid redistribution of the transferrin receptor to the cell surface of HL-60 cells and K562 cells upon treatment with dimethyl sulfoxide due to slowing of endocytosis. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 276:278-284.
  Full Text via DOI: 10.1016/0003-9861(90)90039-2
Conference Poster (Faculty180)
Meeting Abstract (Web of Science)
- 2015
  
  Guanylate-Binding Proteins (GBPs): Large cytokine-induced GTPases that regulate the cytoskeleton. CYTOKINE. 103-103.
  Full Text via DOI: 10.1016/j.cyto.2015.08.216
- 2011
  
  mGBP-2, an IFN-gamma-induced 67-kDa GTPase, inhibits TNF-alpha induction of Matrix Metalloproteinase-9 (MMP-9) transcription by inhibiting the activation of Rac and NF-kappa B. CYTOKINE. 23-23.
  Full Text via DOI: 10.1016/j.cyto.2011.07.046
- 2010
  
  The IFN-induced large GTPase, mGBP-2, inhibits Rac activation initiated by integrin engagement or treatment with either PDGF or TNF-alpha. CYTOKINE. 14-14.
  Full Text via DOI: 10.1016/j.cyto.2010.07.062
- 2009
  
  The IFN-induced gtpase, MGBP-2, inhibits TNF-alpha induction of matrix metalloproteinase-9 (MMP-9) by inhibiting activation of NF-kappa B and RAC 1. CYTOKINE. 122-122.
  Full Text via DOI: 10.1016/j.cyto.2009.07.514
- 2009
  
  Inhibition of cell spreading by the interferon-\#947;-induced large GTPase, mGBP-2, requires prenylation.. CANCER RESEARCH.
- 2008
  
  MGBP-2 inhibits RAC activation by platelet-derived growth factor or integrin engagement: Possible role of phosphatidylinositol 3-kinase. CYTOKINE. 328-328.
  Full Text via DOI: 10.1016/j.cyto.2008.07.442
- 2007
  
  The pro-inflammatory cytokine-induced GTPase, mGBP-2, inhibits RAC activation by both PDGF treatment and cell spreading. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 718-718.
- 2006
  
  Genetic analysis of the human and murine Guanylate Binding Protein (GBP) gene clusters.. CANCER RESEARCH.
Proceedings (Faculty180)
- 1995
  
  The disruption of the gene for the transcription factor PU. 1 leads to multiple hematopoietic defects
Review Article (Web of Science)
- 2011
  
  The Guanylate-Binding Proteins: Emerging Insights into the Biochemical Properties and Functions of This Family of Large Interferon-Induced Guanosine Triphosphatase. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 89-97.
  Full Text via DOI: 10.1089/jir.2010.0102
- 2005
  
  The guanylate-binding proteins (GBPs): Proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 435-443.
- 2005
  
  Review:The Guanylate-Binding Proteins (GBPs): Proinflammatory Cytokine-Induced Members of the Dynamin Superfamily with Unique GTPase Activity. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 435-443.
  Full Text via DOI: 10.1089/jir.2005.25.435

full name

Deborah J Vestal

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