David J Kennedy
-
Associate Professor (Tenured)
Co-Director-Medical School Research Curriculum
Co-Director, Women & Philanthropy Instrumentation Center
Co-Director, Medical Student Mentored Research Program, Medicine , College of Medicine and Life Sciences
Overview
overview
-
David Kennedy received his Ph.D. in Biomedical Science from the Medical College of Ohio and completed the Morgenthaler Fellowship in Cell Biology at the Cleveland Clinic’s Lerner Research Institute. His lab studies how interrelated organ systems such as heart, kidney and liver regulate cellular damage and repair during the course of chronic ailments such as heart failure, hypertension, diabetes, obesity and chronic kidney disease. As a member of the University of Toledo Water Task Force his laboratory places a special emphasis on discovering new diagnostic, preventative and therapeutic strategies targeting cellular damage caused by environmental stressors that impair our land-water-food nexus.
Publications
selected publications
-
Article (Web of Science)
-
2021Regulation of Na/K-ATPase expression by cholesterol: isoform specificity and the molecular mechanism. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 319:C1107-C1119.Full Text via DOI: 10.1152/ajpcell.00083.2020 PMID: 32997514
-
2021Budget constrained machine learning for early prediction of adverse outcomes for COVID-19 patients. SCIENTIFIC REPORTS. 11.Full Text via DOI: 10.1038/s41598-021-98071-z PMID: 34599200
-
2021Toward Revealing Microcystin Distribution in Mouse Liver Tissue Using MALDI-MS Imaging. TOXINS. 13.Full Text via DOI: 10.3390/toxins13100709 PMID: 34679004
-
2021Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22.Full Text via DOI: 10.3390/ijms22189939 PMID: 34576099
-
2020A strategic expression method of miR-29b and its anti-fibrotic effect based on RNA-sequencing analysis. PLOS ONE. 15.Full Text via DOI: 10.1371/journal.pone.0244065 PMID: 33332475
-
2020Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes. JOURNAL OF PERSONALIZED MEDICINE. 10.Full Text via DOI: 10.3390/jpm10040146 PMID: 32992731
-
2020Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity. CHEMOSPHERE. 257.Full Text via DOI: 10.1016/j.chemosphere.2020.127111 PMID: 32485513
-
2020CD40 Receptor Knockout Protects against Microcystin-LR (MC-LR) Prolongation and Exacerbation of Dextran Sulfate Sodium (DSS)-Induced Colitis. BIOMEDICINES. 8.Full Text via DOI: 10.3390/biomedicines8060149 PMID: 32498446
-
2020Harmful Algal Bloom Toxicity inLithobates catesbeianaTadpoles. TOXINS. 12.Full Text via DOI: 10.3390/toxins12060378 PMID: 32521650
-
2020Development and Application of Extraction Methods for LC-MS Quantification of Microcystins in Liver Tissue. TOXINS. 12.Full Text via DOI: 10.3390/toxins12040263 PMID: 32325806
-
2020Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na + /K + ‐ATPase‐α‐1. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 9.Full Text via DOI: 10.1161/jaha.119.013933
-
2020Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 9.Full Text via DOI: 10.1161/jaha.119.014072
-
2019Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease. TOXINS. 11.Full Text via DOI: 10.3390/toxins11090486 PMID: 31450746
-
2019Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease. JOURNAL OF CLINICAL MEDICINE. 8.Full Text via DOI: 10.3390/jcm8071034 PMID: 31311140
-
2019Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis. TOXINS. 11.Full Text via DOI: 10.3390/toxins11060371 PMID: 31242640
-
2019The Effect of Electronic-Cigarette Vaping on Cardiac Function and Angiogenesis in Mice. SCIENTIFIC REPORTS. 9.Full Text via DOI: 10.1038/s41598-019-40847-5
-
2019CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 39:263-275.Full Text via DOI: 10.1161/atvbaha.118.312186
-
2019Proinflammatory Effects of Cardiotonic Steroids Mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src Complex in Renal Epithelial Cells and Immune Cells. HYPERTENSION. 74:73-82.Full Text via DOI: 10.1161/hypertensionaha.118.12605
-
2018Development and applications of solid-phase extraction and liquid chromatography-mass spectrometry methods for quantification of microcystins in urine, plasma, and serum. JOURNAL OF CHROMATOGRAPHY A. 1573:66-77.Full Text via DOI: 10.1016/j.chroma.2018.08.023
-
2018Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 19.Full Text via DOI: 10.3390/ijms19092566
-
2018Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma. NEPHROLOGY DIALYSIS TRANSPLANTATION. 33:1138-1149.Full Text via DOI: 10.1093/ndt/gfx334
-
2018Paraoxonase 2 prevents the development of heart failure. FREE RADICAL BIOLOGY AND MEDICINE. 121:117-126.Full Text via DOI: 10.1016/j.freeradbiomed.2018.04.583
-
2018Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease. PLOS ONE. 13.Full Text via DOI: 10.1371/journal.pone.0197688
-
2016Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy. SCIENTIFIC REPORTS. 6.Full Text via DOI: 10.1038/srep34592
-
2016Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/JAHA.116.004106
-
2016Regulation of Cardiac Remodeling by Cardiac Na+/K+-ATPase Isoforms. FRONTIERS IN PHYSIOLOGY. 7.Full Text via DOI: 10.3389/fphys.2016.00382
-
2016Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase alpha 1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/JAHA.116.003675
-
2016Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts. PHYSIOLOGICAL GENOMICS. 48:220-229.Full Text via DOI: 10.1152/physiolgenomics.00116.2015
-
2016Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. PHYSIOLOGICAL GENOMICS. 48:950-960.Full Text via DOI: 10.1152/physiolgenomics.00070.2016
-
2016Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/jaha.116.003675
-
2016Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro‐Fibrotic Signaling. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 5.Full Text via DOI: 10.1161/jaha.116.004106
-
2015Oxidized LDL-bound CD36 recruits an Na+/K+-ATPase-Lyn complex in macrophages that promotes atherosclerosis. SCIENCE SIGNALING. 8.Full Text via DOI: 10.1126/scisignal.aaa9623
-
2015CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model. PLOS ONE. 10:e0125126.Full Text via DOI: 10.1371/journal.pone.0125126
-
2015Elevated Plasma Marinobufagenin, An Endogenous Cardiotonic Steroid, Is Associated With Right Ventricular Dysfunction and Nitrative Stress in Heart Failure. CIRCULATION-HEART FAILURE. 8:1068-1076.Full Text via DOI: 10.1161/circheartfailure.114.001976
-
2015Gut Microbiota-Dependent Trimethylamine N -Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease. CIRCULATION RESEARCH. 116:448-455.Full Text via DOI: 10.1161/circresaha.116.305360
-
2014Plasma Ceruloplasmin, a Regulator of Nitric Oxide Activity, and Incident Cardiovascular Risk in Patients with CKD. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 9:462-467.Full Text via DOI: 10.2215/cjn.07720713
-
2013Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. BMC NEPHROLOGY. 14.Full Text via DOI: 10.1186/1471-2369-14-209
-
2013CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in Kidney. HYPERTENSION. 61:216-224.Full Text via DOI: 10.1161/hypertensionaha.112.198770
-
2013Diminished Antioxidant Activity of High-Density Lipoprotein-Associated Proteins in Chronic Kidney Disease. JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2:e000104-e000104.Full Text via DOI: 10.1161/jaha.112.000104
-
2013Increasing Serum Soluble Angiotensin-Converting Enzyme 2 Activity After Intensive Medical Therapy Is Associated With Better Prognosis in Acute Decompensated Heart Failure. JOURNAL OF CARDIAC FAILURE. 19:605-610.Full Text via DOI: 10.1016/j.cardfail.2013.06.296
-
2012Monoclonal Antibody Against Marinobufagenin Reverses Cardiac Fibrosis in Rats With Chronic Renal Failure. AMERICAN JOURNAL OF HYPERTENSION. 25:690-696.Full Text via DOI: 10.1038/ajh.2012.17
-
2012CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 303:F1006-F1014.Full Text via DOI: 10.1152/ajprenal.00021.2012
-
2011Endogenous cardiotonic steroids in chronic renal failure. NEPHROLOGY DIALYSIS TRANSPLANTATION. 26:2912-U1511.Full Text via DOI: 10.1093/ndt/gfq772
-
2011A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. CARDIOVASCULAR RESEARCH. 89:604-613.Full Text via DOI: 10.1093/cvr/cvq360
-
2011Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue. DIABETES. 60:1100-1110.Full Text via DOI: 10.2337/db10-1353
-
2011Platelet Activation in Patients with Atherosclerotic Renal Artery Stenosis Undergoing Stent Revascularization. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 6:2185-2191.Full Text via DOI: 10.2215/cjn.03140411
-
2009The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 296:F922-F934.Full Text via DOI: 10.1152/ajprenal.90605.2008
-
2009Dietary Cholesterol Plays a Role in CD36-Mediated Atherogenesis in LDLR-Knockout Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 29:1481-1487.Full Text via DOI: 10.1161/atvbaha.109.191940
-
2008Embolic protection and platelet inhibition during renal artery stenting. CIRCULATION. 117:2752-2760.Full Text via DOI: 10.1161/CIRCULATIONAHA.107.730259
-
2008Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 294:F450-F454.Full Text via DOI: 10.1152/ajprenal.00472.2007
-
2008Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II. CARDIOVASCULAR RESEARCH. 78:185-196.Full Text via DOI: 10.1093/cvr/cvm093
-
2008Embolic Protection and Platelet Inhibition During Renal Artery Stenting. CIRCULATION. 117:2752-2760.Full Text via DOI: 10.1161/circulationaha.107.730259
-
2007Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. HYPERTENSION. 49:215-224.Full Text via DOI: 10.1161/01.HYP.0000252409.36927.05
-
2007Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. 311:388-395.Full Text via DOI: 10.1016/j.jmmm.2006.10.1160
-
2007Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy. HYPERTENSION. 49:215-224.Full Text via DOI: 10.1161/01.hyp.0000252409.36927.05
-
2006Quality of life improves after renal artery stenting. BIOLOGICAL RESEARCH FOR NURSING. 8:129-137.Full Text via DOI: 10.1177/1099800406291459
-
2006HYPOKALEMIA POTENTIATES OUABAIN'S EFFECT ON CALCIUM CYCLING AND CARDIAC GROWTH. CELLULAR AND MOLECULAR BIOLOGY. 52:87-91.Full Text via DOI: 10.1170/T765
-
2006MOLECULAR INSIGHTS INTO UREMIC CARDIOMYOPATHY: CARDIOTONIC STEROIDS AND NA/K ATPASE SIGNALING. CELLULAR AND MOLECULAR BIOLOGY. 52:3-14.Full Text via DOI: 10.1170/T753
-
2005Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells. KIDNEY INTERNATIONAL. 67:1868-1877.Full Text via DOI: 10.1111/j.1523-1755.2005.00285.x
-
2004Plasma expansion by polyethylene-glycol-modified albumin. CLINICAL SCIENCE. 107:263-272.Full Text via DOI: 10.1042/cs20040001
-
2003Effect of Chronic Renal Failure on Cardiac Contractile Function, Calcium Cycling, and Gene Expression of Proteins Important for Calcium Homeostasis in the Rat. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 14:90-97.Full Text via DOI: 10.1097/01.asn.0000037403.95126.03
-
2003Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat. KIDNEY INTERNATIONAL. 63:1785-1790.Full Text via DOI: 10.1046/j.1523-1755.2003.00914.x
-
2003Renal insufficiency as a predictor of adverse events and mortality after renal artery stent placement. AMERICAN JOURNAL OF KIDNEY DISEASES. 42:926-935.Full Text via DOI: 10.1016/j.ajkd.2003.06.004
-
2000Renal artery angioplasty and stent placement: Predictors of a favorable outcome. AMERICAN HEART JOURNAL. 139:64-71.Full Text via DOI: 10.1016/s0002-8703(00)90310-7
-
-
Editorial Material (Web of Science)
-
2020Getting to the Heart and Soul of Chronic Kidney Disease. JOURNAL OF THE AMERICAN HEART ASSOCIATION.Full Text via DOI: 10.1161/jaha.120.017427
-
-
Meeting Abstract (Web of Science)
-
2020Paraoxonase-1 regulation of Na/K-ATPase alpha-1 Src signaling in Chronic Kidney Disease. FASEB JOURNAL.Full Text via DOI: 10.1096/fasebj.2020.34.s1.06643
-
2019ASSESSMENT OF LIVER ENZYMES FOR THE DIAGNOSIS OF MICROCYSTIN INDUCED HEPATOTOXICITY IN THE SETTING OF PRE-EXISTING LIVER DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 895-895.Full Text via DOI: 10.1136/jim-2019-midwestern2019.52
-
2019CARDIOPROTECTIVE EFFECTS OF PARAOXANASE 3 IN A DAHL SALT-SENSITIVE RAT MODEL OF CHRONIC KIDNEY DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 866-866.Full Text via DOI: 10.1136/jim-2019-midwestern2019.9
-
2019HEPATIC INJURY ASSOCIATED WITH REDUCED URINARY EXCRETION AND ALTERED HEPATIC SIGNALING PATHWAYS FOLLOWING CHRONIC LOW DOSE EXPOSURE TO MICROCYSTIN-LR IN A MURINE MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 938-939.Full Text via DOI: 10.1136/jim-2019-midwestern2019.120
-
2019PARAOXANASE 1 DELETION LEADS TO INCREASED CARDIAC REMODELING AND CARDIAC FIBROSIS IN A DAHL SALT-SENSITIVE RAT MODEL OF CHRONIC KIDNEY DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 866-866.Full Text via DOI: 10.1136/jim-2019-midwestern2019.8
-
2019TARGETED DISRUPTION OF NA/K-ATPASE- SRC SIGNALING CASCADE SIGNIFICANTLY REDUCES RENAL INFLAMMATION AND OXIDATIVE STRESS FOLLOWING 5/6TH PARTIAL NEPHRECTOMY. JOURNAL OF INVESTIGATIVE MEDICINE. 920-920.Full Text via DOI: 10.1136/jim-2019-midwestern2019.91
-
2018CARDIOTONIC STEROID SIGNALING THROUGH NA/ K-ATPASE-A-1 AND SRC KINASE ENHANCE FUNCTIONAL INTERACTIONS BETWEEN IMMUNE CELLS AND ENDO/EPITHELIAL CELLS. JOURNAL OF INVESTIGATIVE MEDICINE. 859-859.Full Text via DOI: 10.1136/jim-2018-000745.140
-
2018EVIDENCE OF HEPATOTOXICITY FOLLOWING CHRONIC LOW DOSE EXPOSURE TO MICROCYSTIN-LR IN A MURINE MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 824-824.Full Text via DOI: 10.1136/jim-2018-000745.75
-
2018PARAOXONASE REGULATION OF CARDIOTONIC STEROIDS IN CHRONIC KIDNEY DISEASE. JOURNAL OF INVESTIGATIVE MEDICINE. 865-865.Full Text via DOI: 10.1136/jim-2018-000745.149
-
2017CARDTIOTONIC STEROIDS MEDIATE INFLAMMATION IN RENAL EPITHELIUM VIA THE NA/K-ATPASE ALPHA-1-SRC KINASE SIGNALING PATHWAY. JOURNAL OF INVESTIGATIVE MEDICINE. 851-852.Full Text via DOI: 10.1136/jim-2017-000448.99
-
2016[OP.2B.01] CIGARETTE USE ALTERS ASSESSMENT OF GLOMERULAR FILTRATION RATE. JOURNAL OF HYPERTENSION. e19.Full Text via DOI: 10.1097/01.hjh.0000491375.39951.be
-
2016[PP.31.10] ENDOTHELIAL CELL GROWTH SUPPLEMENT IMPROVES CARDIAC FUNCTION FOLLOWING MOUSE MYOCARDIAL INFARCTION. JOURNAL OF HYPERTENSION. e316-e317.Full Text via DOI: 10.1097/01.hjh.0000492267.97823.ab
-
2015ELEVATED PLASMA MARINOBUFAGENIN, AN ENDOGENOUS CARDIOTONIC STEROID, IS ASSOCIATED WITH RIGHT VENTRICULAR DYSFUNCTION AND NITRATIVE STRESS IN HEART FAILURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. A776.Full Text via DOI: 10.1016/s0735-1097(15)60776-8
-
2012DIMINISHED SERUM ARYLESTERASE ACTIVITY LEVELS IN PULMONARY HYPERTENSION SECONDARY TO LEFT HEART DISEASE IS NOT RELATED TO DYSREGULATED ARGININE METHYLATION.. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. E1613.Full Text via DOI: 10.1016/s0735-1097(12)61614-3
-
2008Platelet activation during renal artery. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. B76-B76.
-
2004Association of renal insufficiency with eccentric left ventricular hypertrophy in patients with renal artery stenosis. JOURNAL OF CARDIAC FAILURE. S40.Full Text via DOI: 10.1016/j.cardfail.2004.06.079
-
-
Review Article (Web of Science)
-
2021Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall. BIOMEDICINES.Full Text via DOI: 10.3390/biomedicines9040404 PMID: 33917965
-
2018Cardiotonic Steroids and the Sodium Trade Balance: New Insights into Trade-Off Mechanisms Mediated by the Na+/K+-ATPase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms19092576
-
2011Pathogenic Role of Scavenger Receptor CD36 in the Metabolic Syndrome and Diabetes. Metabolic Syndrome and Related Disorders. 239-245.Full Text via DOI: 10.1089/met.2011.0003
-
Contact
full name
- David J Kennedy
visualizations
Cumulative publications in Scholars@UToledo