Bashar Kahaleh
- Chief, Division Rheumatology & Immunology, Medicine , College of Medicine and Life Sciences
Contact Info
Publications
selected publications
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Article (Faculty180)
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1992Enhances expresson of high affinity IL-2 receptors (HIL-2-R) in scleroderma: Possible role for IL-6. Clinical Immunology Immunopathology . 62:97-102.
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1992The role of vascular endothelium in fibroblast activation and tissue fibrosis, particularly in scleroderma (sytemic sclerosis) and pachydermoperiostosis (primary hypertropic osteoarthropathy). Clinical Experimental Rheumatology . 10:51-56.
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1991Soluble Immunologic products in scleroderma sera.. Clinical Immunology Immunopathy . 58:139-144.
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1990The Role of Vascular Endothelium in the Pathogenesis of Connective Tissue Diseases: endothelial injury. activation, participation and response . Clinical Experimental Rheumatology . 8:595-601.
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1989A strategy for Scleroderma (systemic sclerosis): is transforming growth factor beta the answer? . Arthritis and Rheumatism . 32:817-825.
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1989Interkeukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration . Annals of Internal Medicine. 110:446-450.
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1989The Vascular dsiease in scleroderma in endothelial cell T-lymphocyte-fibroblast interactions . Rheumatology Disease Clinics of North America . 16:53-73.
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1989Transititons in generalized scleroderma: delayed diffue cutaneous syatemic sclerosis in three patients. . Journal of Rheumatology. 16:554-556.
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1988Effect of lymphotoxin and tumor necrosis factor on endothelial and connective tissue cell growth and function . Clinical Immunology Immunopathology . 49:261-272.
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1986Scharstein KK. Clinical Immunology Immunopatholgy . 39:242-249.
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1986The acute phase response in scleroderma. Differing response to intravenous PGE1. Clinical and Experimental Rheumatology . 4:341-345.
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1985Enhanced platelet adhesion to collagen in scleroderma. . Journal of of Rheumatology . 12:468-471.
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1983Acute Rheumatic Fever After Thyroid Abscess in an Adult. South Medical Journal . 76:810-812.
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1983Endothelial injury in scleroderma. A protease mechanism.. Journal of Clinical Medicine . 101:553-560.
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1982Elevated levels in circulating platelet aggregates and Beta-thrombuliln in scleroderma. Annual of Internal Medicine . 610-613.
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1982Pulse corticosteroid therapy for refractory thrombocytopenia in systemic lupus erythematous . Journal of Rheumatology . 9:311-314.
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1981Plasmapheresis and immune-suppressive drug therapy in scleroderma. . Arthritis and Rheumatism . 24:1128-1136.
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1981Three siblings with scleroderma (systemic sclerosis) and two with Raynaud's Phenomenon from a single kindered . Arthrtis and Rheuamtism . 24:482-484.
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1980Increased factor VII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and Raynaud's phenomenon. Annuals of Internal Medicine . 23:341-343.
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1980Undifferentiated connective syndromes. Arthritis and Rheumatism . 23:341-343.
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1979DNA binding activity of serum from patients with sytemic lupus erythematosus . Clinical and Experimental Immunology . 35:356-363.
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1979Endothelial injury in scleroderma . Journal of Experimental Medicine . 149:1326-1335.
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1979Nephelometric detection of soluble immune complexes: Methodology and clinical applications . International Archives of Allergy Immunology. 58:401-410.
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1979Progressive Systemic Sclerosis: Kidney Involvement . Clinical Rheumatology Disorders . 5:167-184.
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Article (Web of Science)
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2021Genome-wide DNA methylation pattern in systemic sclerosis microvascular endothelial cells: Identification of epigenetically affected key genes and pathways. JOURNAL OF SCLERODERMA AND RELATED DISORDERS.Full Text via DOI: 10.1177/23971983211033772
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2021Epigenetic down-regulation of microRNA-126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.Full Text via DOI: 10.1111/jcmm.16727 PMID: 34137496
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2020Ultrasound-mediated topical delivery of econazole nitrate with potential for treating Raynaud's phenomenon. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 580.Full Text via DOI: 10.1016/j.ijpharm.2020.119229 PMID: 32184178
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2019Evaluation of topical econazole nitrate formulations with potential for treating Raynaud's phenomenon. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. 24:689-699.Full Text via DOI: 10.1080/10837450.2019.1578371 PMID: 30712434
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2018Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin. FRONTIERS IN IMMUNOLOGY. 9.Full Text via DOI: 10.3389/fimmu.2018.02191
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2018There is a need for new systemic sclerosis subset criteria. A content analytic approach. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 47:62-70.Full Text via DOI: 10.1080/03009742.2017.1299793
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2017Digital Ulcers in Ssc Treated with Oral Treprostinil: A Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Follow-up. JOURNAL OF SCLERODERMA AND RELATED DISORDERS. 2:42-49.Full Text via DOI: 10.5301/jsrd.5000232
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2017Tendonitis and Tendon Rupture After Treatment With Rituximab: A Case Series. AMERICAN JOURNAL OF THERAPEUTICS. 24:e592-e595.Full Text via DOI: 10.1097/mjt.0000000000000591
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2016Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. ARTHRITIS RESEARCH & THERAPY. 18.Full Text via DOI: 10.1186/s13075-016-1122-y
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2016Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines. RHEUMATOLOGY. 55:745-754.Full Text via DOI: 10.1093/rheumatology/kev399
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2015Epigenetics, the holy grail in the pathogenesis of systemic sclerosis. RHEUMATOLOGY. 54:1759-1770.Full Text via DOI: 10.1093/rheumatology/keu155
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2014International consensus criteria for the diagnosis of Raynaud's phenomenon. JOURNAL OF AUTOIMMUNITY. 48-49:60-65.Full Text via DOI: 10.1016/j.jaut.2014.01.020
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20132013 Classification Criteria for Systemic Sclerosis An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative. ARTHRITIS AND RHEUMATISM. 65:2737-2747.Full Text via DOI: 10.1002/art.38098
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20132013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. ANNALS OF THE RHEUMATIC DISEASES. 72:1747-1755.Full Text via DOI: 10.1136/annrheumdis-2013-204424
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2013Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 17:1291-1299.Full Text via DOI: 10.1111/jcmm.12105
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2013Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition. ARTHRITIS AND RHEUMATISM. 65:258-269.Full Text via DOI: 10.1002/art.37705
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2012Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise. ARTHRITIS CARE & RESEARCH. 64:351-357.Full Text via DOI: 10.1002/acr.20679
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2011Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. ARTHRITIS RESEARCH & THERAPY. 13.Full Text via DOI: 10.1186/ar3242
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2010Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. ARTHRITIS AND RHEUMATISM. 62:2488-2498.Full Text via DOI: 10.1002/art.27522
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2009MQX-503, a Novel Formulation of Nitroglycerin, Improves the Severity of Raynaud's Phenomenon A Randomized, Controlled Trial. ARTHRITIS AND RHEUMATISM. 60:870-877.Full Text via DOI: 10.1002/art.24351
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2008The microvascular endothelium in scleroderma. RHEUMATOLOGY. 47:V14-V15.Full Text via DOI: 10.1093/rheumatology/ken279
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2008Vascular disease in scleroderma: Mechanisms of vascular injury. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA. 34:57-+.Full Text via DOI: 10.1016/j.rdc.2007.12.004
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2006Association between enhanced type I collagen expression and epigenetic repression of theFLI1 gene in scleroderma fibroblasts. ARTHRITIS AND RHEUMATISM. 54:2271-2279.Full Text via DOI: 10.1002/art.21948
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2006Differential expression of stromal cell–derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications. ARTHRITIS AND RHEUMATISM. 54:3022-3033.Full Text via DOI: 10.1002/art.22047
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2006Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, β2 integrin–mediated connection with actin cytoskeleton in human microvascular endothelial cells: Failure of association in systemic sclerosis endothelial cells. ARTHRITIS AND RHEUMATISM. 54:3926-3938.Full Text via DOI: 10.1002/art.22263
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2005The antiangiogenic tissue kallikrein pattern of endothelial cells in systemic sclerosis. ARTHRITIS AND RHEUMATISM. 52:3618-3628.Full Text via DOI: 10.1002/art.21383
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2004Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. ARTHRITIS AND RHEUMATISM. 50:3275-3285.Full Text via DOI: 10.1002/art.20562
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2002The effect of dynamic versus isometric resistance training on pain and functioning among adults with osteoarthritis of the knee. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 83:1187-1195.Full Text via DOI: 10.1053/apmr.2002.33988
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2001Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma). ANNALS OF THE RHEUMATIC DISEASES. 60:487-494.Full Text via DOI: 10.1136/ard.60.5.487
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1995Recommendations for off-label use of intravenously administered immunoglobulin preparations. University Hospital Consortium Expert Panel for Off-Label Use of Polyvalent Intravenously Administered Immunoglobulin Preparations. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 273:1865-1870.Full Text via DOI: 10.1001/jama.273.23.1865
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1994Lymphocyte interactions with the vascular endothelium in systemic sclerosis. Clinics in Dermatology. 12:361-367.Full Text via DOI: 10.1016/0738-081x(94)90288-7
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Case Study (Faculty180)
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1981
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Chapter (Faculty180)
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1991Connective tissue disorders: Lupus erythematous, dermatomyositis, and scleroderma. Conn's Current Therapy . Harcourt Brad and Company .
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1990Mechanisms of Vascular Disease. Scleroderma. Springer . 227.
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1986Polymyalgia rheumatic and temporal arteritis. Conn's Current Therapy . WB Saunders . 793-794.
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1985The vascular disease in scleroderma. Current Topics in Rheumatology . Gower Medical Publishing Limited . 242-248.
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1983Lethal Midline Granuloma . Clinical Dermatology . Harper&Row. Unit 5.
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1983Wegner's Granulomitis. Clinical Dermatitis. Harpers and Row. Unit 9.
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Editorial Material (Web of Science)
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2009Statistics and the Relationship of Clinical Research to Clinical Practice. JOURNAL OF RHEUMATOLOGY. 219-220.Full Text via DOI: 10.3899/jrheum.081206
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2004Progress in research into systemic sclerosis. LANCET. 561-562.Full Text via DOI: 10.1016/s0140-6736(04)16864-5
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Letter (Web of Science)
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2018Recurrent Episodes of Myocardial Infarction in a 25-Year-Old Young Man With Systemic Lupus Erythematosus. ARCHIVES OF RHEUMATOLOGY. 102-104.Full Text via DOI: 10.5606/archrheumatol.2018.6518
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1998An elderly man with vasculitis and IgA myeloma. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 186-187.Full Text via DOI: 10.1111/j.1468-3083.1998.tb00725.x
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Meeting Abstract (Web of Science)
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2015THERE IS A NEED FOR NEW SYSTEMIC SCLEROSIS SUBSET CRITERIA. A CONTENT ANALYTIC APPROACH. ANNALS OF THE RHEUMATIC DISEASES. 1141-1141.Full Text via DOI: 10.1136/annrheumdis-2015-eular.2277
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Other Scholarly Work (Faculty180)
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1985Scleroderm: Diagnosis; Scleroderma Treatment; Raynaud's Phenomenon . Southern Medical Association Dial Access Program. .
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Review Article (Web of Science)
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2021Similarities between COVID-19 and systemic sclerosis early vasculopathy: A "viral" challenge for future research in scleroderma. AUTOIMMUNITY REVIEWS.Full Text via DOI: 10.1016/j.autrev.2021.102899 PMID: 34274540
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2021The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts' Consensus. AUTOIMMUNITY REVIEWS.Full Text via DOI: 10.1016/j.autrev.2020.102738 PMID: 33326854
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2020Epigenetics and systemic sclerosis: An answer to disease onset and evolution?. EUROPEAN JOURNAL OF RHEUMATOLOGY. S147-S156.Full Text via DOI: 10.5152/eurjrheum.2020.19112 PMID: 32697935
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2020Molecular mechanisms underlying rheumatoid arthritis and cancer development and treatment. FUTURE ONCOLOGY. 483-495.Full Text via DOI: 10.2217/fon-2019-0722 PMID: 32100561
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2019Mechanism and biomarkers in aortitis--a review. JOURNAL OF MOLECULAR MEDICINE-JMM. 11-23.Full Text via DOI: 10.1007/s00109-019-01838-1 PMID: 31664480
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2019An interim report of the Scleroderma Clinical Trials Consortium working groups. JOURNAL OF SCLERODERMA AND RELATED DISORDERS. 17-27.Full Text via DOI: 10.1177/2397198318783926 PMID: 30906878
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2018The role of the dermatologist in Raynaud's phenomenon: a clinical challenge. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 1120-1127.Full Text via DOI: 10.1111/jdv.14914 PMID: 29512213
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2015Epigenetics and systemic sclerosis. SEMINARS IN IMMUNOPATHOLOGY. 453-462.Full Text via DOI: 10.1007/s00281-015-0504-6
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2014Endothelial dysfunction in systemic sclerosis. CURRENT OPINION IN RHEUMATOLOGY. 615-620.Full Text via DOI: 10.1097/bor.0000000000000112
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2013Cardiovascular disease in autoimmune rheumatic diseases. AUTOIMMUNITY REVIEWS. 1004-1015.Full Text via DOI: 10.1016/j.autrev.2013.03.013
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2013Review: Evidence That Systemic Sclerosis Is a Vascular Disease. ARTHRITIS AND RHEUMATISM. 1953-1962.Full Text via DOI: 10.1002/art.37988
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Contact
full name
- Bashar Kahaleh
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Cumulative publications in Scholars@UToledo