Kahaleh, Bashar

Bashar Kahaleh
Close

Positions

Chief, Division Rheumatology & Immunology, Medicine , College of Medicine and Life Sciences

Contact Info

Bashar.Kahaleh@utoledo.edu

selected publications

Article (Faculty180)
- 1992
  
  Enhances expresson of high affinity IL-2 receptors (HIL-2-R) in scleroderma: Possible role for IL-6. Clinical Immunology Immunopathology . 62:97-102.
- 1992
  
  The role of vascular endothelium in fibroblast activation and tissue fibrosis, particularly in scleroderma (sytemic sclerosis) and pachydermoperiostosis (primary hypertropic osteoarthropathy). Clinical Experimental Rheumatology . 10:51-56.
- 1991
  
  Endothelin, and endothelial - dependent vasoconstrictor in scleroderma. Ehanced production and a profibrotic action . Arthritis and Rheumatism . 34:1991.
- 1991
  
  Soluble Immunologic products in scleroderma sera.. Clinical Immunology Immunopathy . 58:139-144.
- 1990
  
  The Role of Vascular Endothelium in the Pathogenesis of Connective Tissue Diseases: endothelial injury. activation, participation and response . Clinical Experimental Rheumatology . 8:595-601.
- 1989
  
  A strategy for Scleroderma (systemic sclerosis): is transforming growth factor beta the answer? . Arthritis and Rheumatism . 32:817-825.
- 1989
  
  Interkeukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration . Annals of Internal Medicine. 110:446-450.
- 1989
  
  The Immune basis for human fibrotic diseases, especially scleroderma (systemic sclerosis). Clinical Aspects of Autoimmunity . 3:19-28.
- 1989
  
  The Vascular dsiease in scleroderma in endothelial cell T-lymphocyte-fibroblast interactions . Rheumatology Disease Clinics of North America . 16:53-73.
- 1989
  
  Transititons in generalized scleroderma: delayed diffue cutaneous syatemic sclerosis in three patients. . Journal of Rheumatology. 16:554-556.
- 1988
  
  Effect of lymphotoxin and tumor necrosis factor on endothelial and connective tissue cell growth and function . Clinical Immunology Immunopathology . 49:261-272.
- 1986
  
  A modified scleroderma skin scoring method . Clinical and Experimental Rheumatology . 4:367-369.
- 1986
  
  Effect of scleroderma serum on human fibroblast collagen production: Possible selection through proliferation. Journal of Rheumatology . 13:99-102.
- 1986
  
  Scharstein KK. Clinical Immunology Immunopatholgy . 39:242-249.
- 1986
  
  The acute phase response in scleroderma. Differing response to intravenous PGE1. Clinical and Experimental Rheumatology . 4:341-345.
- 1985
  
  Enhanced platelet adhesion to collagen in scleroderma. . Journal of of Rheumatology . 12:468-471.
- 1983
  
  A Fibroblast mitogen present in scleroderma but no control sera: inhiition by proteinase inhibitors.. Rheumatology International . 3:35-38.
- 1983
  
  Acute Rheumatic Fever After Thyroid Abscess in an Adult. South Medical Journal . 76:810-812.
- 1983
  
  Endothelial injury in scleroderma. A protease mechanism.. Journal of Clinical Medicine . 101:553-560.
- 1982
  
  Elevated levels in circulating platelet aggregates and Beta-thrombuliln in scleroderma. Annual of Internal Medicine . 610-613.
- 1982
  
  Pulse corticosteroid therapy for refractory thrombocytopenia in systemic lupus erythematous . Journal of Rheumatology . 9:311-314.
- 1981
  
  Plasmapheresis and immune-suppressive drug therapy in scleroderma. . Arthritis and Rheumatism . 24:1128-1136.
- 1981
  
  Three siblings with scleroderma (systemic sclerosis) and two with Raynaud's Phenomenon from a single kindered . Arthrtis and Rheuamtism . 24:482-484.
- 1980
  
  Increased factor VII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and Raynaud's phenomenon. Annuals of Internal Medicine . 23:341-343.
- 1980
  
  Undifferentiated connective syndromes. Arthritis and Rheumatism . 23:341-343.
- 1979
  
  DNA binding activity of serum from patients with sytemic lupus erythematosus . Clinical and Experimental Immunology . 35:356-363.
- 1979
  
  Endothelial injury in scleroderma . Journal of Experimental Medicine . 149:1326-1335.
- 1979
  
  Nephelometric detection of soluble immune complexes: Methodology and clinical applications . International Archives of Allergy Immunology. 58:401-410.
- 1979
  
  Progressive Systemic Sclerosis: Kidney Involvement . Clinical Rheumatology Disorders . 5:167-184.
Article (Web of Science)
- 2021
  
  Genome-wide DNA methylation pattern in systemic sclerosis microvascular endothelial cells: Identification of epigenetically affected key genes and pathways. JOURNAL OF SCLERODERMA AND RELATED DISORDERS.
  Full Text via DOI: 10.1177/23971983211033772
- 2021
  
  Epigenetic down-regulation of microRNA-126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.
  Full Text via DOI: 10.1111/jcmm.16727 PMID: 34137496
- 2020
  
  Ultrasound-mediated topical delivery of econazole nitrate with potential for treating Raynaud's phenomenon. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 580.
  Full Text via DOI: 10.1016/j.ijpharm.2020.119229 PMID: 32184178
- 2019
  
  Evaluation of topical econazole nitrate formulations with potential for treating Raynaud's phenomenon. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. 24:689-699.
  Full Text via DOI: 10.1080/10837450.2019.1578371 PMID: 30712434
- 2018
  
  Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin. FRONTIERS IN IMMUNOLOGY. 9.
  Full Text via DOI: 10.3389/fimmu.2018.02191
- 2018
  
  There is a need for new systemic sclerosis subset criteria. A content analytic approach. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 47:62-70.
  Full Text via DOI: 10.1080/03009742.2017.1299793
- 2017
  
  Digital Ulcers in Ssc Treated with Oral Treprostinil: A Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Follow-up. JOURNAL OF SCLERODERMA AND RELATED DISORDERS. 2:42-49.
  Full Text via DOI: 10.5301/jsrd.5000232
- 2017
  
  Tendonitis and Tendon Rupture After Treatment With Rituximab: A Case Series. AMERICAN JOURNAL OF THERAPEUTICS. 24:e592-e595.
  Full Text via DOI: 10.1097/mjt.0000000000000591
- 2016
  
  Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. ARTHRITIS RESEARCH & THERAPY. 18.
  Full Text via DOI: 10.1186/s13075-016-1122-y
- 2016
  
  Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines. RHEUMATOLOGY. 55:745-754.
  Full Text via DOI: 10.1093/rheumatology/kev399
- 2015
  
  Epigenetics, the holy grail in the pathogenesis of systemic sclerosis. RHEUMATOLOGY. 54:1759-1770.
  Full Text via DOI: 10.1093/rheumatology/keu155
- 2014
  
  International consensus criteria for the diagnosis of Raynaud's phenomenon. JOURNAL OF AUTOIMMUNITY. 48-49:60-65.
  Full Text via DOI: 10.1016/j.jaut.2014.01.020
- 2013
  
  2013 Classification Criteria for Systemic Sclerosis An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative. ARTHRITIS AND RHEUMATISM. 65:2737-2747.
  Full Text via DOI: 10.1002/art.38098
- 2013
  
  2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. ANNALS OF THE RHEUMATIC DISEASES. 72:1747-1755.
  Full Text via DOI: 10.1136/annrheumdis-2013-204424
- 2013
  
  Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 17:1291-1299.
  Full Text via DOI: 10.1111/jcmm.12105
- 2013
  
  Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition. ARTHRITIS AND RHEUMATISM. 65:258-269.
  Full Text via DOI: 10.1002/art.37705
- 2012
  
  Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise. ARTHRITIS CARE & RESEARCH. 64:351-357.
  Full Text via DOI: 10.1002/acr.20679
- 2011
  
  Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. ARTHRITIS RESEARCH & THERAPY. 13.
  Full Text via DOI: 10.1186/ar3242
- 2010
  
  Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. ARTHRITIS AND RHEUMATISM. 62:2488-2498.
  Full Text via DOI: 10.1002/art.27522
- 2009
  
  MQX-503, a Novel Formulation of Nitroglycerin, Improves the Severity of Raynaud's Phenomenon A Randomized, Controlled Trial. ARTHRITIS AND RHEUMATISM. 60:870-877.
  Full Text via DOI: 10.1002/art.24351
- 2008
  
  The microvascular endothelium in scleroderma. RHEUMATOLOGY. 47:V14-V15.
  Full Text via DOI: 10.1093/rheumatology/ken279
- 2008
  
  Vascular disease in scleroderma: Mechanisms of vascular injury. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA. 34:57-+.
  Full Text via DOI: 10.1016/j.rdc.2007.12.004
- 2006
  
  Association between enhanced type I collagen expression and epigenetic repression of theFLI1 gene in scleroderma fibroblasts. ARTHRITIS AND RHEUMATISM. 54:2271-2279.
  Full Text via DOI: 10.1002/art.21948
- 2006
  
  Differential expression of stromal cell–derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications. ARTHRITIS AND RHEUMATISM. 54:3022-3033.
  Full Text via DOI: 10.1002/art.22047
- 2006
  
  Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, β2 integrin–mediated connection with actin cytoskeleton in human microvascular endothelial cells: Failure of association in systemic sclerosis endothelial cells. ARTHRITIS AND RHEUMATISM. 54:3926-3938.
  Full Text via DOI: 10.1002/art.22263
- 2005
  
  The antiangiogenic tissue kallikrein pattern of endothelial cells in systemic sclerosis. ARTHRITIS AND RHEUMATISM. 52:3618-3628.
  Full Text via DOI: 10.1002/art.21383
- 2004
  
  Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. ARTHRITIS AND RHEUMATISM. 50:3275-3285.
  Full Text via DOI: 10.1002/art.20562
- 2002
  
  The effect of dynamic versus isometric resistance training on pain and functioning among adults with osteoarthritis of the knee. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 83:1187-1195.
  Full Text via DOI: 10.1053/apmr.2002.33988
- 2001
  
  Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma). ANNALS OF THE RHEUMATIC DISEASES. 60:487-494.
  Full Text via DOI: 10.1136/ard.60.5.487
- 1995
  
  Recommendations for off-label use of intravenously administered immunoglobulin preparations. University Hospital Consortium Expert Panel for Off-Label Use of Polyvalent Intravenously Administered Immunoglobulin Preparations. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 273:1865-1870.
  Full Text via DOI: 10.1001/jama.273.23.1865
- 1994
  
  Lymphocyte interactions with the vascular endothelium in systemic sclerosis. Clinics in Dermatology. 12:361-367.
  Full Text via DOI: 10.1016/0738-081x(94)90288-7
Case Study (Faculty180)
- 1987
  
  Vacuities and renal disease in nail-patella syndrome: case report and literature review . 562-564.
- 1981
  
  Cytotoxic factors specific for endothelial cells. . 1081-3.
Chapter (Faculty180)
- 1991
  
  Connective tissue disorders: Lupus erythematous, dermatomyositis, and scleroderma. Conn's Current Therapy . Harcourt Brad and Company .
- 1990
  
  Mechanisms of Vascular Disease. Scleroderma. Springer . 227.
- 1990
  
  Proteinase in fibrosis of systemic sclerosis. Enzymes as Targets for Drug Design . Palfreyman MG. 219-224.
- 1986
  
  Polymyalgia rheumatic and temporal arteritis. Conn's Current Therapy . WB Saunders . 793-794.
- 1985
  
  The vascular disease in scleroderma. Current Topics in Rheumatology . Gower Medical Publishing Limited . 242-248.
- 1984
  
  Scleroderma (systemic sclerosis: Treatment and clinical manifestations as related to pathogenesis. Progress in Clinical Rheumatology . Grue and Statton. 71-110.
- 1983
  
  Lethal Midline Granuloma . Clinical Dermatology . Harper&Row. Unit 5.
- 1983
  
  Wegner's Granulomitis. Clinical Dermatitis. Harpers and Row. Unit 9.
Editorial Material (Web of Science)
- 2009
  
  Statistics and the Relationship of Clinical Research to Clinical Practice. JOURNAL OF RHEUMATOLOGY. 219-220.
  Full Text via DOI: 10.3899/jrheum.081206
- 2004
  
  Progress in research into systemic sclerosis. LANCET. 561-562.
  Full Text via DOI: 10.1016/s0140-6736(04)16864-5
Letter (Web of Science)
- 2018
  
  Recurrent Episodes of Myocardial Infarction in a 25-Year-Old Young Man With Systemic Lupus Erythematosus. ARCHIVES OF RHEUMATOLOGY. 102-104.
  Full Text via DOI: 10.5606/archrheumatol.2018.6518
- 1998
  
  An elderly man with vasculitis and IgA myeloma. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 186-187.
  Full Text via DOI: 10.1111/j.1468-3083.1998.tb00725.x
Meeting Abstract (Web of Science)
- 2015
  
  THERE IS A NEED FOR NEW SYSTEMIC SCLEROSIS SUBSET CRITERIA. A CONTENT ANALYTIC APPROACH. ANNALS OF THE RHEUMATIC DISEASES. 1141-1141.
  Full Text via DOI: 10.1136/annrheumdis-2015-eular.2277
Other Scholarly Work (Faculty180)
- 1985
  
  Scleroderm: Diagnosis; Scleroderma Treatment; Raynaud's Phenomenon . Southern Medical Association Dial Access Program. .
Review Article (Web of Science)
- 2021
  
  Similarities between COVID-19 and systemic sclerosis early vasculopathy: A "viral" challenge for future research in scleroderma. AUTOIMMUNITY REVIEWS.
  Full Text via DOI: 10.1016/j.autrev.2021.102899 PMID: 34274540
- 2021
  
  The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts' Consensus. AUTOIMMUNITY REVIEWS.
  Full Text via DOI: 10.1016/j.autrev.2020.102738 PMID: 33326854
- 2020
  
  Epigenetics and systemic sclerosis: An answer to disease onset and evolution?. EUROPEAN JOURNAL OF RHEUMATOLOGY. S147-S156.
  Full Text via DOI: 10.5152/eurjrheum.2020.19112 PMID: 32697935
- 2020
  
  Molecular mechanisms underlying rheumatoid arthritis and cancer development and treatment. FUTURE ONCOLOGY. 483-495.
  Full Text via DOI: 10.2217/fon-2019-0722 PMID: 32100561
- 2019
  
  Mechanism and biomarkers in aortitis--a review. JOURNAL OF MOLECULAR MEDICINE-JMM. 11-23.
  Full Text via DOI: 10.1007/s00109-019-01838-1 PMID: 31664480
- 2019
  
  An interim report of the Scleroderma Clinical Trials Consortium working groups. JOURNAL OF SCLERODERMA AND RELATED DISORDERS. 17-27.
  Full Text via DOI: 10.1177/2397198318783926 PMID: 30906878
- 2018
  
  The role of the dermatologist in Raynaud's phenomenon: a clinical challenge. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 1120-1127.
  Full Text via DOI: 10.1111/jdv.14914 PMID: 29512213
- 2015
  
  Epigenetics and systemic sclerosis. SEMINARS IN IMMUNOPATHOLOGY. 453-462.
  Full Text via DOI: 10.1007/s00281-015-0504-6
- 2014
  
  Endothelial dysfunction in systemic sclerosis. CURRENT OPINION IN RHEUMATOLOGY. 615-620.
  Full Text via DOI: 10.1097/bor.0000000000000112
- 2013
  
  Cardiovascular disease in autoimmune rheumatic diseases. AUTOIMMUNITY REVIEWS. 1004-1015.
  Full Text via DOI: 10.1016/j.autrev.2013.03.013
- 2013
  
  Review: Evidence That Systemic Sclerosis Is a Vascular Disease. ARTHRITIS AND RHEUMATISM. 1953-1962.
  Full Text via DOI: 10.1002/art.37988

full name

Bashar Kahaleh

visualizations

Cumulative publications in Scholars@UToledo

Co-author Network