Amit K Tiwari
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Assistant Professor
Associate Professor, Pharmacology , College of Pharmacy and Pharmaceutical Sciences
Publications
selected publications
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Article (Faculty180)
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2021Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis. Frontiers in Bioengineering and Biotechnology.
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2021Bruton's Tyrosine Kinase Targeting in Multiple Myeloma. International journal of molecular sciences. 22.
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2021Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells. Pharmaceutical research. 38:851-871.
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2021Novel stilbene scaffolds efficiently target Mycobacterium tuberculosis nucleoid-associated protein, HU. NEW JOURNAL OF CHEMISTRY. 45:10683-10692.
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2021Resveratrol-loaded nanomedicines for cancer applications. Cancer reports (Hoboken, N.J.). 4:e1353.
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2021Strategies for the integration of foundational and clinical sciences in doctor of pharmacy programs. JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY. n/a.
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2021The interaction of the bioflavonoids with five SARS-CoV-2 proteins targets: An in silico study. Comput Biol Med. 134:104464-104464.
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2021The role of endolysosomal trafficking in anticancer drug resistance. Drug Resistance Updates. 57:100769.
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2021The use of zebrafish model in prostate cancer therapeutic development and discovery. Cancer chemotherapy and pharmacology. 87:311-325.
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2021The validity of mobile applications to facilitate patient care provided to cancer patients: opportunities and limitations. Recent Patents on Anti-Cancer Drug Discovery. 4.
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2021
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2020
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2020Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities. Pharmaceutics. 12:152.
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2020Amide Bond Bioisosteres: Strategies, Synthesis, and Successes. Journal of Medicinal Chemistry.
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2020CCR5 and responses to cocaine: Addiction is not just about the brain. Brain, Behavior, and Immunity. 84:8â9.
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2020CCR5 and responses to cocaine: Addiction is not just about the brain. Brain Behavior and Immunity. 84:8-9.
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2020Edaravone: A potential treatment for the COVID-19-induced inflammatory syndrome?. Pharmacol Res. 160:105055-105055.
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2020Editorial: The Role of Breast Cancer Stem Cells in Clinical Outcomes. Frontiers in Oncology. 10:299.
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2020Evaluation of Cytotoxicity and Taste-Masking Effect of Selected Flavors on Dental Lidocaine HCl Injection. Pharmaceuticals (Basel, Switzerland). 13.
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2020Flavonoids as Multi-Target Compounds: A Special Emphasis on their Potential as Chemo-adjuvants in Cancer Therapy. Current Pharmaceutical Design. 26:1712-1728.
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2020Fluorinated diphenylalanine analogue based supergelators: a stencil that accentuates the sustained release of antineoplastic drugs. Supramolecular Chemistry. 1-13.
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2020Insights on the Thermal and Physical Stability of the Modified Polymerizable Liposomes for Improved Photoactivity. International Journal of Lipids. 1:21-33.
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2020Oral and dermal toxicity of alkenones extracted from Isochrysis species. Frontiers in bioscience (Landmark edition). 25:817-837.
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2020Potential Use of Sofosbuvir in the Prophylaxis for Rabies. Front Pharmacol. 11:472-472.
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2020Role of eIF4A1 in triple-negative breast cancer stem-like cell-mediated drug resistance. Cancer Reports. n/a:e1299.
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2020Stability-indicating HPLC method for acyclovir and lidocaine in topical formulations. Biomedical chromatography : BMC. 34:e4751.
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2019Advances in Ultrasound Mediated Transdermal Drug Delivery. Current pharmaceutical design. 25:413-423.
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2019Alcohol and cocaine exposure modulates ABCB1 and ABCG2 transporters in male alcohol preferring rats. Molecular Neurobiology. 56:1921-1932.
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2019Cytokine gene expression following RSV-A infection. Frontiers in bioscience (Landmark edition). 24:463-481.
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2019Microalgae derived alkenones and their applications. . Oceanography & Fisheries Open Access Journal.
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2019Novel and Alternative Targets against Breast Cancer Stemness to Combat Chemoresistance. Frontiers in Oncology.
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2019
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2019
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2019Role of Ceramides in Drug Delivery. AAPS PharmSciTech.
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2019Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness. Frontiers in oncology. 9:1311.
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2019
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2018Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats. Molecular neurobiology. 1.
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2018Alkenones as a Promising Green Alternative for Waxes in Cosmetics and Personal Care Products. Journal of Cosmetics.
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2018An auxin--tyrosine derivative based biocompatible supergelator: a template for fabrication of nanoparticles for sustained release of model drugs. New Journal of Chemistry. 42:4915.
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2018Bax/tubulin/epithelial-mesenchymal pathways determine the efficacy of silybin analog HM015k in colorectal cancer cell growth and metastasis. Frontiers in Pharmacology. 9:520.
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2018CYTOTOXICITY OF INHALABLE DRY POWDERS IN A549 HUMAN LUNG CANCER CELL LINE. FARMACIA. 66:172.
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2018Effects of consumption of whole grape powder on basal NF-$\kappa$B signaling and inflammatory cytokine secretion in a mouse model of inflammation. Journal of Nutrition \& Intermediary Metabolism. 11:1.
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2018Efficient Syntheses and Anti-Cancer Activity of Xenortides AD Including ent/epi-Stereoisomers. Organic & Biomolecular Chemistry.
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2018MHC-B haplotypes impact susceptibility and resistance to RSV-A infection. Frontiers in bioscience (Elite edition). 10:506â519.
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2018Modulation of the ATP-binding cassette B1 transporter by neuro-inflammatory cytokines: role in the pathogenesis of Alzheimer’s disease. Frontiers in pharmacology. 9:658.
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2018New camphor hybrids: lipophilic enhancement improves antimicrobial efficacy against drug-resistant pathogenic microbes and intestinal worms. Medicinal Chemistry Research. 27:1728.
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2018Sofosbuvir: A Potential Treatment for Ebola. Frontiers in pharmacology. 9:1139.
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2018lH-Pyrazolo [3, 4-b] quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest. Bioorganic \& medicinal chemistry letters.
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20172, 3-Diaryl-3H-imidazo [4, 5-b] pyridine derivatives as potential anticancer and anti-inflammatory agents. Acta Pharmaceutica Sinica B. 7:73.
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2017Cancer chemoprevention through dietary flavonoids: what’s limiting?. Chinese Journal of Cancer. 36:50.
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2017Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive--Based, natural product lead optimization approach. European Journal of Medicinal Chemistry. 133:365.
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2017Exploration of small RNA-seq data for small non-coding RNAs in Human Colorectal Cancer. Journal of genomics. 5:16.
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2017HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies. Frontiers in pharmacology. 8:498.
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2017In vivo Studies for Drug Development via Oral Delivery: Challenges,Animal Models and Techniques. Pharmaceutica Analytica Acta. 8:1-11.
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2017N-(1H-Pyrazol-3-yl) quinazolin-4-amines as a novel class of casein kinase 1$\delta$/$\varepsilon$ inhibitors: Synthesis, biological evaluation and molecular modeling studies. Bioorganic \& Medicinal Chemistry Letters. 27:2663.
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2017
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2017Synthesis and Antibreast Cancer Activity Testing of Some N-Arylidene-4-Phenyl-1H-Pyrazol-3-Amine Derivatives.. International Journal of Pharmacy \& Life Sciences. 8.
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2017The Epigenomics of Embryonic Pathway Signaling in Colorectal Cancer. Frontiers in pharmacology. 8:267.
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2017Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. European journal of medicinal chemistry. 138:1053.
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2016Infectious Complications Following Prostate Biopsy: A Single Institution Review. Journal of Cancer Research Updates. 5:126.
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2016Natural Polyphenols in Cancer Chemoresistance. Nutrition and Cancer. 68:879.
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2016Pain in the management of opioid use disorder. Journal of pain research. 9:963.
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2016Tackling multidrug resistance mediated by efflux transporters in tumor-initiating cells. Expert opinion on drug metabolism \& toxicology. 12:633.
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2016Targeting chemo-resistant colon cancer by inhibiting embryonic resistance pathways. Cancer Research. 76:2950.
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2015Abstract B57: Gnetin C, a novel resveratrol dimer, targets pancreatic cancer metabolism. Cancer Research. 75:B57.
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2015Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs. Bioorganic & medicinal chemistry. 23:2148.
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2015Diindolylmethane Inhibits the Activity of P-glycoprotein in 17-71 Canine B-Cell Lymphoid Tumor Cells. Auburn University Journal of Undergraduate Scholarship.
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2015Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways. Biochemical pharmacology. 96:65.
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2015IND-2, a pyrimido [1 ″, 2 ″: 1, 5] pyrazolo [3, 4-b] quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells. Bioorganic \& medicinal chemistry. 23:602.
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2015
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2015Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer. Biochemical and biophysical research communications. 463:161.
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2015Stearidonic acid, a plant-based dietary fatty acid, enhances the chemosensitivity of canine lymphoid tumor cells. Biochemical and biophysical research communications. 460:1002.
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2014Sildenafil Enhances the Anticancer Activity of Paclitaxel in an ABCB1-Mediated Multidrug Resistance Xenograft Mouse Model. Journal of Cancer Research Updates. 3:169.
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2013Acquired Legionnaire’s disease through aerosolization of water from natural sources. Trans Clin Biol. 1:6.
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2013Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro).. Pakistan journal of pharmaceutical sciences. 26.
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2013Clinical Significance of PARP-1 Inhibitors in Cancer Chemotherapy. Trans Clin Bio. 1:10.
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2013Investigating the function of single nucleotide polymorphisms in the CTSB gene: a computational approach. Future Neurology. 8:469.
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2013Lipid Metabolism in Mammary Neoplasia and Potential Therapeutic Targets. Cell signaling .
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2013
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2013Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models. Molecular cancer therapeutics. molcanther.
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2013PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Cancer chemotherapy and pharmacology. 72:189.
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2013Repurposing phosphodiesterase-5 inhibitors as chemoadjuvants. Frontiers in Pharmacology. 4:82.
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2013
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2013Translating Mechanistic Knowledge of Diseases in Clinical Treatment. Trans Clin Bio. 1.
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2012Design, synthesis and biological evaluation of N-arylphenyl-2, 2-dichloroacetamide analogues as anti-cancer agents. Bioorganic \& medicinal chemistry letters. 22:7268.
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2012GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2-and ABCB1-mediated drug resistance. Biochemical pharmacology. 83:1613.
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2012OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochemical pharmacology. 84:766.
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2011Analogs of OSI-930 as potent ABCG2-mediated multidrug resistance reversal agents. Cancer Research. 71:1740.
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2011Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. The FEBS journal. 278:3226.
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2011Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells. Chinese journal of cancer. 31:110.
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2011Reversal of ABCB1-and ABCG2-mediated drug resistance by sildenafil. Cancer Research. 71:1739.
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2011Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Current Pharmaceutical Biotechnology. 12:570.
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2011Roles of sildenafil in enhancing drug sensitivity in cancer. Cancer research.
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2011Sildenafil reverses ABCB1-and ABCG2-mediated chemotherapeutic drug resistance. Cancer research. canres.
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2011
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2011
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2010
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2010Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochemical pharmacology. 79:154.
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2010Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by inhibiting its efflux activity. Cancer Research. 70:1533.
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2010The role of stem cell markers in multidrug resistance mediated by ABC transporters. Leukemia research. 34:696.
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2009Current advances in modulation of ABC transporter-mediated multidrug resistance in cancer. Int J Toxicol Pharmcol Res. 1:1.
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2009Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochemical pharmacology. 77:781.
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2009
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Article (Web of Science)
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2021The expression profiles of chemokines, innate immune and apoptotic genes in tumors caused by Rous Sarcoma Virus (RSV-A) in chickens. GENES AND IMMUNITY.Full Text via DOI: 10.1038/s41435-021-00158-0 PMID: 34934184
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2021Polyamide/Poly(Amino Acid) Polymers for Drug Delivery. JOURNAL OF FUNCTIONAL BIOMATERIALS. 12.Full Text via DOI: 10.3390/jfb12040058 PMID: 34698184
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2021Antiproliferative Efficacy of N-(3-chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine, DW-8, in Colon Cancer Cells Is Mediated by Intrinsic Apoptosis. MOLECULES. 26.Full Text via DOI: 10.3390/molecules26154417 PMID: 34361570
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2021The interaction of the bioflavonoids with five SARS-CoV-2 proteins targets: An in silico study. COMPUTERS IN BIOLOGY AND MEDICINE. 134.Full Text via DOI: 10.1016/j.compbiomed.2021.104464 PMID: 34020130
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2021Strategies for the integration of foundational and clinical sciences in doctor of pharmacy programs. JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY.Full Text via DOI: 10.1002/jac5.1482
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2021Novel stilbene scaffolds efficiently target Mycobacterium tuberculosis nucleoid-associated protein, HU. NEW JOURNAL OF CHEMISTRY.Full Text via DOI: 10.1039/d0nj05947a
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2021A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells. CANCERS. 13.Full Text via DOI: 10.3390/cancers13081954 PMID: 33919653
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2021Novel Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells. PHARMACEUTICAL RESEARCH. 38:851-871.Full Text via DOI: 10.1007/s11095-021-03043-7
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2020Amide Bond Bioisosteres: Strategies, Synthesis, and Successes. JOURNAL OF MEDICINAL CHEMISTRY. 63:12290-12358.Full Text via DOI: 10.1021/acs.jmedchem.0c00530 PMID: 32686940
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2020Co-Delivery of Hispolon and Doxorubicin Liposomes Improves Efficacy Against Melanoma Cells. AAPS PHARMSCITECH. 21.Full Text via DOI: 10.1208/s12249-020-01846-2 PMID: 33150503
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2020Evaluation of Cytotoxicity and Taste-Masking Effect of Selected Flavors on Dental Lidocaine HCl Injection. PHARMACEUTICALS. 13.Full Text via DOI: 10.3390/ph13110353 PMID: 33138130
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2020Fluorinated diphenylalanine analogue based supergelators: a stencil that accentuates the sustained release of antineoplastic drugs. SUPRAMOLECULAR CHEMISTRY.Full Text via DOI: 10.1080/10610278.2020.1808892
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2020Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells. CANCERS. 12.Full Text via DOI: 10.3390/cancers12082169 PMID: 32759815
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2020Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation. MOLECULES. 25.Full Text via DOI: 10.3390/molecules25133063 PMID: 32635530
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2020Mechanoresponsive, proteolytically stable and biocompatible supergelators from ultra short enantiomeric peptides with sustained drug release propensity. NEW JOURNAL OF CHEMISTRY. 44:6346-6354.Full Text via DOI: 10.1039/d0nj00102c
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2020Stability-indicating HPLC method for acyclovir and lidocaine in topical formulations. BIOMEDICAL CHROMATOGRAPHY. 34.Full Text via DOI: 10.1002/bmc.4751 PMID: 31756271
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2020Oral and dermal toxicity of alkenones extracted from Isochrysis species. FRONTIERS IN BIOSCIENCE-LANDMARK. 25:817-837.Full Text via DOI: 10.2741/4836 PMID: 31585919
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2019Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness. FRONTIERS IN ONCOLOGY. 9.Full Text via DOI: 10.3389/fonc.2019.01311 PMID: 31867270
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2019Rationally Designed Bioinspired delta-Amino Valeric Acid Based Hydrogel: One Shot Solution for Drug Delivery and Effluent Management. CHEMISTRYSELECT. 4:6896-6905.Full Text via DOI: 10.1002/slct.201900389
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2019Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro. HELIYON. 5.Full Text via DOI: 10.1016/j.heliyon.2019.e01603 PMID: 31193218
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2019Novel Thienopyrimidine Derivative, RP-010, Induces beta-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells. CANCERS. 11.Full Text via DOI: 10.3390/cancers11050711 PMID: 31126091
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2019Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles. AAPS PHARMSCITECH. 20.Full Text via DOI: 10.1208/s12249-019-1349-4
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2019Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats. MOLECULAR NEUROBIOLOGY. 56:1921-1932.Full Text via DOI: 10.1007/s12035-018-1153-2
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2019Unravelling the potency of 4,5-diamino-4H-1,2,4 triazole-3-thiol derivatives for kinase inhibition using a rational approach. NEW JOURNAL OF CHEMISTRY. 43:1202-1215.Full Text via DOI: 10.1039/c8nj04205e
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2019ABC Transporter-Mediated Multidrug-Resistant Cancer. DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY. 1141:549-580.Full Text via DOI: 10.1007/978-981-13-7647-4_12 PMID: 31571174
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2019Cytokine gene expression following RSV-A infection. FRONTIERS IN BIOSCIENCE-LANDMARK. 24:463-481.Full Text via DOI: 10.2741/4729 PMID: 30468667
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2018Cariprazine, A Dopamine D-2/D-3 Receptor Partial Agonist, Modulates ABCG2-Mediated Multidrug Resistance in Cancer. CANCERS. 10.Full Text via DOI: 10.3390/cancers10090308
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2018Efficient syntheses and anti-cancer activity of xenortides A-D including ent/epi-stereoisomers. ORGANIC & BIOMOLECULAR CHEMISTRY. 16:5332-5342.Full Text via DOI: 10.1039/c8ob00452h
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20181H-Pyrazolo[3,4-b]quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 28:2244-2249.Full Text via DOI: 10.1016/j.bmcl.2018.05.045
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2018New camphor hybrids: lipophilic enhancement improves antimicrobial efficacy against drug-resistant pathogenic microbes and intestinal worms. MEDICINAL CHEMISTRY RESEARCH. 27:1728-1739.Full Text via DOI: 10.1007/s00044-018-2186-9
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2018Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis. FRONTIERS IN PHARMACOLOGY. 9.Full Text via DOI: 10.3389/fphar.2018.00520
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2018An auxin-tyrosine derivative based biocompatible supergelator: a template for fabrication of nanoparticles for sustained release of model drugs. NEW JOURNAL OF CHEMISTRY. 42:4915-4922.Full Text via DOI: 10.1039/c7nj04390b
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2018CYTOTOXICITY OF INHALABLE DRY POWDERS IN A549 HUMAN LUNG CANCER CELL LINE. FARMACIA. 66:172-175.
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2017Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 138:1053-1065.Full Text via DOI: 10.1016/j.ejmech.2017.07.028
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2017Proteolysis-Resistant Self-Assembled omega-Amino Acid Dipeptide-Based Biocompatible Hydrogels as Drug Delivery Vehicle. CHEMISTRYSELECT. 2:6623-6631.Full Text via DOI: 10.1002/slct.201701172
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2017HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies. FRONTIERS IN PHARMACOLOGY. 8.Full Text via DOI: 10.3389/fphar.2017.00498
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2017The dopamine D-3 receptor antagonists PG01037, NGB2904, SB277011A, and U99194 reverse ABCG2 transporter-mediated drug resistance in cancer cell lines. CANCER LETTERS. 396:167-180.Full Text via DOI: 10.1016/j.canlet.2017.03.015
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2017Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive - Based, natural product lead optimization approach. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 133:365-378.Full Text via DOI: 10.1016/j.ejmech.2017.03.033
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2017N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1 delta/epsilon inhibitors: Synthesis, biological evaluation and molecular modeling studies. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 27:2663-2667.Full Text via DOI: 10.1016/j.bmcl.2017.04.080
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20172,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents. ACTA PHARMACEUTICA SINICA B. 7:73-79.Full Text via DOI: 10.1016/j.apsb.2016.05.003 PMID: 28119811
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2017A Comprehensive NGS Data Analysis of Differentially Regulated miRNAs, piRNAs, lncRNAs and sn/snoRNAs in Triple Negative Breast Cancer. JOURNAL OF CANCER. 8:578-596.Full Text via DOI: 10.7150/jca.17633
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2016Pyrimido[1 '',2 '':1,5]pyrazolo[3,4-b]quinolines: Novel compounds that reverse ABCG2-mediated resistance in cancer cells. CANCER LETTERS. 376:118-126.Full Text via DOI: 10.1016/j.canlet.2016.03.030
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2015Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in acolon-26 tumor-bearing mouse model in vivo. CANCER MEDICINE. 4:1767-1780.Full Text via DOI: 10.1002/cam4.520
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2015Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways. BIOCHEMICAL PHARMACOLOGY. 96:65-75.Full Text via DOI: 10.1016/j.bcp.2015.04.016
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2015Stearidonic acid, a plant-based dietary fatty acid, enhances the chemosensitivity of canine lymphoid tumor cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 460:1002-1007.Full Text via DOI: 10.1016/j.bbrc.2015.03.141
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2015Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs. BIOORGANIC & MEDICINAL CHEMISTRY. 23:2148-2158.Full Text via DOI: 10.1016/j.bmc.2015.03.002
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2015IND-2, a pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY. 23:602-611.Full Text via DOI: 10.1016/j.bmc.2014.11.043
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2013BBA, a Synthetic Derivative of 23-hydroxybutulinic Acid, Reverses Multidrug Resistance by Inhibiting the Efflux Activity of MRP7 (ABCC10). PLOS ONE. 8:e74573.Full Text via DOI: 10.1371/journal.pone.0074573
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2013Investigating the function of single nucleotide polymorphisms in the CTSB gene: a computational approach. Future Neurology. 8:469-483.Full Text via DOI: 10.2217/fnl.13.26
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2013Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. CANCER LETTERS. 328:307-317.Full Text via DOI: 10.1016/j.canlet.2012.10.001
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2013Overlapping Functions of ABC Transporters in Topotecan Disposition as Determined in Gene Knockout Mouse Models. MOLECULAR CANCER THERAPEUTICS. 12:1343-1355.Full Text via DOI: 10.1158/1535-7163.mct-13-0100
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2013PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. CANCER CHEMOTHERAPY AND PHARMACOLOGY. 72:189-199.Full Text via DOI: 10.1007/s00280-013-2184-z
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2012Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 22:7268-7271.Full Text via DOI: 10.1016/j.bmcl.2012.07.057
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2012GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. BIOCHEMICAL PHARMACOLOGY. 83:1613-1622.Full Text via DOI: 10.1016/j.bcp.2012.02.028
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2012OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. BIOCHEMICAL PHARMACOLOGY. 84:766-774.Full Text via DOI: 10.1016/j.bcp.2012.06.019
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2012Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leukemia cells. CHINESE JOURNAL OF CANCER. 31:110-118.Full Text via DOI: 10.5732/cjc.011.10327
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2012PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Science. 103:1531-1537.Full Text via DOI: 10.1111/j.1349-7006.2012.02328.x
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2011Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance. CANCER RESEARCH. 71:3029-3041.Full Text via DOI: 10.1158/0008-5472.can-10-3820
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2011The Phosphodiesterase-5 Inhibitor Vardenafil Is a Potent Inhibitor of ABCB1/P-Glycoprotein Transporter. PLOS ONE. 6:e19329.Full Text via DOI: 10.1371/journal.pone.0019329
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2011Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells. ONCOLOGY LETTERS. 2:549-556.Full Text via DOI: 10.3892/ol.2011.288
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2010Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters. CANCER RESEARCH. 70:7981-7991.Full Text via DOI: 10.1158/0008-5472.can-10-0111
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2010Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. BIOCHEMICAL PHARMACOLOGY. 79:154-161.Full Text via DOI: 10.1016/j.bcp.2009.08.021
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2009Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10). PLOS ONE. 4:e7520.Full Text via DOI: 10.1371/journal.pone.0007520
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2009Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. BIOCHEMICAL PHARMACOLOGY. 77:781-793.Full Text via DOI: 10.1016/j.bcp.2008.11.007
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2009Nilotinib (AMN107, Tasigna®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. BIOCHEMICAL PHARMACOLOGY. 78:153-161.Full Text via DOI: 10.1016/j.bcp.2009.04.002
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2009Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. CANCER LETTERS. 279:74-83.Full Text via DOI: 10.1016/j.canlet.2009.01.027
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2008Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2. CANCER RESEARCH. 68:7905-7914.Full Text via DOI: 10.1158/0008-5472.can-08-0499
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Book Chapter (Web of Science)
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2021Alternative approaches to overcome chemoresistance to apoptosis in cancer. APOPTOSIS IN HEALTH AND DISEASE, PT B. 91-122.Full Text via DOI: 10.1016/bs.apcsb.2021.01.005 PMID: 34090621
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Case Study (Faculty180)
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Chapter (Faculty180)
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2020In search of novel tau inhibitors and their role in Alzheimer's therapy. A closer look at kinase inhibitions. Nova Science Publishers Inc.. 157-192.
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2019ABC Transporter-Mediated Multidrug-Resistant Cancer. ABC Transporter-Mediated Multidrug-Resistant Cancer. Springer Singapore. 549-580.
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2019ABC transporters: their role in mediating multi-drug resistance in cancer. Advances in Experimental Medicine and Biology. Springer Nature. 1141.
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2019Resveratrol loaded nanomedicines for cancer applications. Nanomedicines for Bioacctives - Healthcare Applications. Springer Nature Press.
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2015Nanoparticle-Based Therapeutics to Circumvent Cancer Chemoresistance. NanoBiomedicine: Nanostructured Drug Delivery. . Nanostructured Drug Delivery. Studium Press. 383-408.
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2013Anti-cancer Role of Phosphodiesterase-5 Inhibitors. The Research and Biology of Cancer. ISBN: 978-1-477554-999..
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2012Molecular Mechanisms of Methotrexate Resistance. Methotrexate: Pharmacology, Clinical Uses and Adverse Effects. Nova Science Publishers .
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Conference Poster (Faculty180)
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Correction (Web of Science)
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2017Cancer chemoprevention through dietary flavonoids: what's limiting? (vol 36, 50, 2017). CHINESE JOURNAL OF CANCER. 1-1.Full Text via DOI: 10.1186/s40880-017-0237-0
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Dissertation (Faculty180)
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Early Access (Web of Science)
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2021Resveratrol-loaded nanomedicines for cancer applications. CANCER REPORTS.Full Text via DOI: 10.1002/cnr2.1353 PMID: 33655717
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2021The use of zebrafish model in prostate cancer therapeutic development and discovery. CANCER CHEMOTHERAPY AND PHARMACOLOGY.Full Text via DOI: 10.1007/s00280-020-04211-z PMID: 33392639
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2020Role of eIF4A1 in triple-negative breast cancer stem-likecell-mediateddrug resistance. CANCER REPORTS.Full Text via DOI: 10.1002/cnr2.1299 PMID: 33053607
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Editorial Material (Web of Science)
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2020Edaravone: A potential treatment for the COVID-19-induced inflammatory syndrome?. PHARMACOLOGICAL RESEARCH.Full Text via DOI: 10.1016/j.phrs.2020.105055 PMID: 32619723
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2020Potential Use of Sofosbuvir in the Prophylaxis for Rabies. FRONTIERS IN PHARMACOLOGY.Full Text via DOI: 10.3389/fphar.2020.00472 PMID: 32322214
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2020Editorial: The Role of Breast Cancer Stem Cells in Clinical Outcomes. FRONTIERS IN ONCOLOGY.Full Text via DOI: 10.3389/fonc.2020.00299 PMID: 32211328
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2020CCR5 and responses to cocaine: Addiction is not just about the brain. BRAIN BEHAVIOR AND IMMUNITY. 8-9.Full Text via DOI: 10.1016/j.bbi.2019.12.008 PMID: 31843646
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2018Sofosbuvir: A Potential Treatment for Ebola. FRONTIERS IN PHARMACOLOGY.Full Text via DOI: 10.3389/fphar.2018.01139
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2016Pain in the management of opioid use disorder. JOURNAL OF PAIN RESEARCH. 963-966.Full Text via DOI: 10.2147/JPR.S123667
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2016Pain in the management of opioid use disorder. JOURNAL OF PAIN RESEARCH. 963-966.Full Text via DOI: 10.2147/jpr.s123667
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2010The role of stem cell markers in multidrug resistance mediated by ABC transporters. Leukemia Research. 696-697.Full Text via DOI: 10.1016/j.leukres.2009.12.007
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Lecture or Panel Discussion (Faculty180)
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2018International Presentation: Novel technologies to target multidrug resistant cancers. Special Session Talk, XIV International Congress of Scientific Research (XIV CIC), Santo Domingo, Dominican Republic.
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2018Keynote Lecture: Have you explored the researcher in you?. 5th Annual Student College of Clinical Pharmacy Research Conference, University of Toledo, OH.
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2018Novel technologies inducing unique cell death mechanism in cancer. Bio-engineering Seminar Series, Dept. of Bioengineering, University of Toledo, OH.
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2018Novel technologies to overcome drug resistance in cancer. Guest lecture series, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
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2018Targeting apoptotic resistance – Induction of a unique cell death mechanisms in cancer. Seminar Series, College of Pharmacy, Manchester University, IN.
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2017Methuophagy induction targets apoptosis resistance. Toledo Cancer Symposium, Toledo Ohio.
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2017Overcoming multidrug resistance” and “Methuophagy induction, a new approach against drug resistance. Indo-US Conference on Drug Resistance – New Threats and Global Challenge, RIPER, Anantpur, India.
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2017The use of Non-invasive pharmacokinetic analysis using Hybrid Optoacoustic Ultrasound Technology. St. Michael’s Hospital Toronto, Canada.
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2017Unconventional caspase-independent mechanisms to target drug resistance. Synergy Cancer Pharmacology Conference, Queens, NY.
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2016Avenues and Challenges to Current Chemotherapy Development. International Conference on Emerging Frontiers in Drug Discovery and Development. Rajiv Gandhi Prodyogik Vishwavidyalaya, M.P. India .
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2016Drug Resistance: Can we get rid of ‘em. Graduate Students Seminar Series, Rajiv Gandhi Prodyogik Vishwavidyalaya, M.P. India.
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2016Invited Plenary Lecture: Advances in triple negative breast cancer therapy. 1st Annual Breast Cancer Summit at St. Rita’s Medical Lima, Ohio.
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2015Challenges and future directions of targeted anticancer drug discovery.. Ohio State University, Department of Surgery and Medicine, Columbus, OH .
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2015Implications of efflux transporters in animal chemotherapeutics. Animal Science and College of Veterinary Medicine, Tuskegee University, Tuskegee, Al.
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2015Pharmaceutical Sciences as a Career Option for STEM majors. Research Experience for Undergraduate (REU), The Center for Nanobiotechnology Research, Alabama State University, Al.
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2015Targeted anticancer drug discovery and development. . Anatrace Pharmaceuticals, Toledo, OH .
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2014Anticancer drug development: Integrating Pharmacokinetic/ Pharmacodynamic approaches with systems biology. Fairleigh Dickinson University, Florham Park, NJ .
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2014Implications of efflux transporters in anticancer therapy and resistance. Alabama State University, Montgomery, Al .
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2014Polymorphic alterations in efflux transporters affect anticancer disposition. GMaP Maryland Conference invited by John’s Hopkins University, Bethesda, MD.
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2013Complimentary roles of efflux transporters in anticancer disposition. Mitchell Cancer Institute, University of South Alabama, Mobile, Al .
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2012Overlapping functions of efflux transporters in drug disposition. Tuskegee University, AL.
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2012Redundant functions of ABC transporters in topotecan disposition. Dept of Pharmacology and Systems Therapeutics. Mount Sinai School of Medicine, NY.
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2011Nilotinib (Tasigna®) reverses ABCB1- and ABCG2-mediated drug resistance by inhibiting their efflux function. Albert Einstein College of Medicine, Bronx, NY.
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2010PDE5 inhibitors as modulators of MDR. 7th National ABC transporters meeting, NCI, NIH, Bethesda, MD 20892.
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2008Differential Effects of the EGFR Tyrosine Kinase Inhibitor AG1478 on the Function of ABCB1 and ABCG2. 5th Northern American ABC transporters meeting, NCI, NIH, Bethesda, MD 20892.
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2007Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine. 4th Northern American ABC transporters meeting, NCI, NIH, Bethesda, MD .
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2006Bifidogenic effect and power of immunity. Nestle Nutrition Symposium, Bareily, U.P, India.
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Meeting Abstract (Web of Science)
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2016Zosuquidar, an MDR1 inhibitor, activates human pxr to induce CYP3A4 and MDR1 gene expression. DRUG METABOLISM REVIEWS. 81-81.
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Patent (Faculty180)
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Presentation (Faculty180)
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Press (Faculty180)
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2016Collaborating for a cure. College of Pharmacy, Newsletter.
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2016Thought of the month. Rajiv Gandhi Prodyogik Vishwavidyalaya Newsletter, India.
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Proceedings (Faculty180)
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Review Article (Web of Science)
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2021Infectious Keratitis: An Update on Role of Epigenetics. FRONTIERS IN IMMUNOLOGY.Full Text via DOI: 10.3389/fimmu.2021.765890 PMID: 34917084
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2021The role of endolysosomal trafficking in anticancer drug resistance. DRUG RESISTANCE UPDATES.Full Text via DOI: 10.1016/j.drup.2021.100769 PMID: 34217999
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2021Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities. PHARMACEUTICS.Full Text via DOI: 10.3390/pharmaceutics13070960 PMID: 34206728
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2021Bruton's Tyrosine Kinase Targeting in Multiple Myeloma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.Full Text via DOI: 10.3390/ijms22115707 PMID: 34071917
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2021Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.Full Text via DOI: 10.3389/fbioe.2021.633671 PMID: 33777909
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2020Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities. PHARMACEUTICS.Full Text via DOI: 10.3390/pharmaceutics12020152 PMID: 32070011
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2020Flavonoids as Multi-Target Compounds: A Special Emphasis on their Potential as Chemo-adjuvants in Cancer Therapy. CURRENT PHARMACEUTICAL DESIGN. 1712-1728.Full Text via DOI: 10.2174/1381612826666200128095248 PMID: 32003663
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2019Novel and Alternative Targets Against Breast Cancer Stemness to Combat Chemoresistance. FRONTIERS IN ONCOLOGY.Full Text via DOI: 10.3389/fonc.2019.01003 PMID: 31681564
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2019Role of Ceramides in Drug Delivery. AAPS PHARMSCITECH.Full Text via DOI: 10.1208/s12249-019-1497-6 PMID: 31410612
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2019Advances in Ultrasound Mediated Transdermal Drug Delivery. CURRENT PHARMACEUTICAL DESIGN. 413-423.Full Text via DOI: 10.2174/1381612825666190211163948 PMID: 30747058
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2019Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma. AAPS PHARMSCITECH. 250.Full Text via DOI: 10.1208/s12249-019-1457-1
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2017Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway. NUTRIENTS.Full Text via DOI: 10.3390/nu9080911
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2017Cancer chemoprevention through dietary flavonoids: what's limiting?. CHINESE JOURNAL OF CANCER.Full Text via DOI: 10.1186/s40880-017-0217-4
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2017The Epigenomics of Embryonic Pathway Signaling in Colorectal Cancer. FRONTIERS IN PHARMACOLOGY.Full Text via DOI: 10.3389/fphar.2017.00267
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2016Tackling multidrug resistance mediated by efflux transporters in tumor-initiating cells. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. 633-644.Full Text via DOI: 10.1080/17425255.2016.1179280
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2016Natural Polyphenols in Cancer Chemoresistance. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL. 879-891.Full Text via DOI: 10.1080/01635581.2016.1192201
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2015Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 161-166.Full Text via DOI: 10.1016/j.bbrc.2015.05.041
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2011Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. FEBS JOURNAL. 3226-3245.Full Text via DOI: 10.1111/j.1742-4658.2011.08235.x
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2011Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer: Figure 1.. CANCER RESEARCH. 3735-3738.Full Text via DOI: 10.1158/0008-5472.can-11-0375
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2010BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review. Leukemia Research. 1255-1268.Full Text via DOI: 10.1016/j.leukres.2010.04.016
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