Khalaf, Reema Ab A; Alqazaqi, Shorooq; Aburezeq, Maram; Sabbah, Dima; Albadawi, Ghadeer; Sheikha, Ghassan Ab A
description
Diabetes mellitus is a chronic metabolic disorder, characterized by hyperglycemia over a prolonged period, disturbance of fat, protein, and carbohydrate metabolism, resulting from defective insulin secretion, insulin action or both. Dipeptidyl peptidase-IV (DPP-IV) inhibitors are relatively a new class of oral hypoglycemic agents that reduce the deterioration of gutderived endogenous incretin hormones secreted in response to food ingestion to stimulate the secretion of insulin from beta cells of the pancreas.
