Design, synthesis, and biological evaluation of benzylamino-methanone based cholesteryl ester transfer protein inhibitors Article (Faculty180)

cited authors

  • Abu Sheikha, Ghassan; Abu Khalaf, Reema; Melhem, Areej; Albadawi, Ghadeer

description

  • Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating dyslipidemia and related disorders. Guided by our previously-reported pharmacophore and QSAR models for CETP inhibition, we synthesized and bioassayed a series of benzylamino-methanones. The most potent illustrated 30% CETP inhibition at 10 microM.

authors

publication date

  • 2010

published in

start page

  • 5721

end page

  • 33

volume

  • 15