Most sexually transmitted infections (STIs) are rarely seen by medical providers as life-threatening or as a source of severe sequelae. Human immunodeficiency virus and syphilis screening are still not universal and are affected by provider and patient misconceptions. We chose to discuss 3 STIs that can lead to significant morbidity and even mortality: neurosyphilis, due to its resurgence in the past years, Mpox due to its changing epidemiology and clinical presentation, and tubo-ovarian abscess due to its huge impact on female fertility and morbidity in general.
