Tang, J L; Subbotin, V M; Antonysamy, M A; Troutt, A B; Rao, A S; Thomson, A W
description
Blocking the action of interleukin (IL) 17 with an IL-17 receptor (R):Fc fusion protein inhibits T-cell proliferative responses to alloantigens and prolongs vascularized heart graft survival. In this study, we examined whether IL-17 antagonism could suppress the development of chronic rejection.