Oropharyngeal aspiration of particulate hexavalent chromium increases chromium levels in lung and liver, and induces essential metal dyshomeostasis in lung, liver, and blood

Meaza, Idoia; Wise, Jamie L; Wise, Sandra S; Lu, Haiyan; Williams, Aggie R; Delnicki, Morgan; Easley, Jack; Kouokam, J Calvi C; Wise, John Pierc P; Vielee, Samuel T; Wise, James T F; Wise, Rachel M; Wise, John Pierc P

Hexavalent chromium [Cr(VI)] is a known human lung carcinogen with widespread exposure risks, yet how it causes cancer is still unclear. Cr(VI) causes dyshomeostasis of essential metals in the brains of exposed rats and is considered a biomarker of lung cancer, yet whether Cr(VI) causes metal dyshomeostasis in the lung is unknown. Cr(VI) particles impact at lung bifurcations causing tumors at these sites, indicating the bronchial branching is a key consideration for its toxicity. This study chose guinea pigs because, like humans, they have a dichotomous bronchiole branching pattern. The aim of this study was to investigate Cr accumulation and essential metal dyshomeotasis in the lung, liver and blood.

Oropharyngeal aspiration of particulate hexavalent chromium increases chromium levels in lung and liver, and induces essential metal dyshomeostasis in lung, liver, and blood Article (Faculty180)