Quantitative and Functional Antibody Responses to the 13-Valent Conjugate and/or 23-Valent Purified Polysaccharide Vaccine in Aging HIV-Infected Adults
Article (Faculty180)
Ohtola, Jennifer A; Saul-McBeth, Jessica L; Iyer, Anita S; Leggat, David J; Khuder, Sadik A; Khaskhely, Noor M; Westerink, Ma Juli J
description
The number of aging human immunodeficiency virus-infected (HIV+) individuals living in the United States has substantially grown over the past two decades. Advanced age and HIV infection both increase susceptibility to infection due to B cell dysfunction. The combined impact of these factors on pneumococcal vaccine responses remains unknown.