Iyer, Anita S; Khaskhely, Noor M; Leggat, David J; Ohtola, Jennifer A; Saul-McBeth, Jessica L; Khuder, Sadik A; Westerink, M A Juli A
description
Members of the Tumor Necrosis Factor (TNF)-superfamily have speculated roles in the response against T-independent type II antigens (TI-II) including pneumococcal polysaccharides (PPS). Dysregulation in their expression is associated with an enhanced risk for pneumococcal disease in neonates but their expression in other high-risk populations including HIV-positive individuals remains to be elucidated.
