Olefin Difunctionalization for the Synthesis of Tetrahydroisoquinoline, Morpholine, Piperazine, and Azepane

Article (Faculty180)

cited authors

  • Chhikara, A; Kaur, N; Wolke, E B; Boes, E A; Nguyen, A M; Ariyarathna, J P; Baskaran, P; Villa, C E; Pham, A H; Kremenets, V J; Kutcher, S R; Truong, J T; Li, W

description

  • <p>This report outlines a versatile strategy for synthesizing a diverse array of N-heterocycles. By the utilization of common olefins, this simple protocol facilitates their coupling with various bifunctional reagents. Furthermore, it can be integrated with C–H amination techniques to directly produce N-heterocycles in a multicomponent cascade coupling process. The unique bond disconnection logic employed in this process underscores its efficiency in achieving rapid simplification through cascade couplings.</p>

authors

publication date

  • 2024

published in

start page

  • 84–88

volume

  • 26