Tunable [3+2] and [4+2] Annulations for Pyrrolidine and Piperidine Synthesis Article (Faculty180)

cited authors

  • Ariyarathna, Jeewani P; Baskaran, Prabagar; Chhikara, Akanksha; Kaur, Navdeep; Nguyen, Alex M; Premathilaka, Shashini; Huynh, Michelle M; Truong, Jonathon T; Li, Wei


  • N-heterocycles are privileged pharmaceutical scaffolds in drug discovery and development. We disclose here divergent intermolecular coupling strategies that can access diverse N-heterocycles directly from olefins. The radical-to-polar mechanistic switching is key for the divergent cyclization processes. These distinctive annulations result in the coupling of alkenes with simple bifunctional reagents for divergent N-heterocycle syntheses.


publication date

  • 2023

published in

start page

  • 6418

end page

  • 6421


  • 59