This case report describes a 15-year-old adolescent female who presented to her primary care clinic with acute onset of painful genital ulcers. She denied ever being sexually active but tested positive for SARS-CoV-2, via PCR, 5-days prior to ulcer development. Associated symptoms on days 1 through 3 included fatigue, nausea, headaches, and fever of 38.3C. Lipschutz ulcers, also known as aphthous ulcers, acute genital ulcers, and acquired genital ulcerations; are an uncommon, self-limiting, non-sexually transmitted condition characterized by the rapid onset of painful, necrotic ulcerations of the vulva or lower vagina. The pathogenesis of Lipschutz Ulcers is unclear and the diagnosis is one of exclusion. This case report describes SARS-CoV-2 infection as a potential immunologic trigger for the development of Lipschutz Ulcers. The clinical presentation, diagnostic reasoning, differential diagnoses, plan of care and patient outcome are discussed.
