Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages Article (Faculty180)

cited authors

  • Lee, Tzong- S; Lin, Chun- Y; Tsai, Jin- Y; Wu, Yuh- L; Su, Kuo- H; Lu, Kuo- Y; Hsiao, S H; Pan, Ching-Chian C; Kou, Yu R; Hsu, Yung- P; Ho, Low- T


  • Resistin promotes macrophage-foam cell formation, but the mechanisms are unclear. In macrophages, lipid uptake is regulated by scavenger receptors (SR-A and CD36), while the cholesterol efflux is regulated by SR-BI, ATP-binding cassette transporter-A1 (ABCA1) and ABCG1. We investigated the mechanisms underlying the dysregulation by resistin of these regulators leading to promotion of lipid accumulation in bone marrow-derived macrophages.


publication date

  • 2009

published in

start page

  • 97

end page

  • 104


  • 84