Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling Article (Faculty180)

cited authors

  • Su, Kuo- H; Tsai, Jin- Y; Kou, Yu R; Chiang, A N; Hsiao, S H; Wu, Yuh- L; Hou, Hsin-Han H; Pan, Ching-Chian C; Shyue, Song- K; Lee, Tzong- S


  • Valsartan, a selective angiotensin II type 1 receptor (AT1R) blocker, has beneficial effects in the cardiovascular system in part by its increase of nitric oxide (NO) bioavailability, yet the mechanisms are unclear. We investigated the molecular mechanisms underlying this effect in endothelial cells (ECs).


publication date

  • 2009

published in

start page

  • 468

end page

  • 75


  • 82