Many paths to methyltransfer: a chronicle of convergence Article (Faculty180)

cited authors

  • Schubert, Heidi L; Blumenthal, Robert M; Cheng, Xiaodong


  • S-adenosyl-L-methionine (AdoMet) dependent methyltransferases (MTases) are involved in biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing. Five different structural folds (I-V) have been described that bind AdoMet and catalyze methyltransfer to diverse substrates, although the great majority of known MTases have the Class I fold. Even within a particular MTase class the amino-acid sequence similarity can be as low as 10%. Thus, the structural and catalytic requirements for methyltransfer from AdoMet appear to be remarkably flexible.

publication date

  • 2003

published in

start page

  • 329

end page

  • 35


  • 28