Evolution of a global regulator: Lrp in four orders of γ-Proteobacteria Article (Faculty180)

cited authors

  • Unoarumhi, Yvette; Blumenthal, Robert M; Matson, Jyl S


  • Bacterial global regulators each regulate the expression of several hundred genes. In Escherichia coli, the top seven global regulators together control over half of all genes. Leucine-responsive regulatory protein (Lrp) is one of these top seven global regulators. Lrp orthologs are very widely distributed, among both Bacteria and Archaea. Surprisingly, even within the phylum γ-Proteobacteria (which includes E. coli), Lrp is a global regulator in some orders and a local regulator in others. This raises questions about the evolution of Lrp and, more broadly, of global regulators.

publication date

  • 2016

published in

start page

  • 111


  • 16